SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vzq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 10 GLY A  33
PHE A  72
GLY A  60
THR A   9
VAL A  31
 None
 1.20A 1v3qE-3vzqA:
2.6		 1v3qE-3vzqA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 9 LEU A 199
GLY A 184
ILE A 186
VAL A 203
ILE A 202
 None
 1.10A 2avoA-3vzqA:
undetectable		 2avoA-3vzqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 12 ILE A  19
ALA A  18
GLY A  14
ILE A 217
GLY A  10
 None
 0.87A 2qe6A-3vzqA:
5.8		 2qe6A-3vzqA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 9 LEU A 199
GLY A 184
ILE A 186
VAL A 203
ILE A 202
 None
 1.18A 3d1yB-3vzqA:
undetectable		 3d1yB-3vzqA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		4 / 5 SER A 140
ILE A  15
TYR A 153
GLY A 184
 None
 1.05A 3uboB-3vzqA:
6.9		 3uboB-3vzqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		3 / 3 GLY A 230
SER A 229
TRP A 223
 None
 0.76A 4e7cD-3vzqA:
undetectable		 4e7cD-3vzqA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		4 / 7 ALA A  57
SER A  38
ARG A  40
GLY A  35
 None
 0.89A 5e26A-3vzqA:
undetectable
5e26B-3vzqA:
undetectable		 5e26A-3vzqA:
20.81
5e26B-3vzqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 9 LEU A 160
GLY A  90
ALA A  89
GLY A  16
ILE A  15
 None
 1.05A 5kr0B-3vzqA:
undetectable		 5kr0B-3vzqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 9 LEU A 199
GLY A 184
ILE A 186
VAL A 203
ILE A 202
 None
 1.05A 5kr2D-3vzqA:
undetectable		 5kr2D-3vzqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 9 LEU A  23
ALA A  24
PHE A  28
VAL A  84
ILE A  86
 None
 1.08A 5om2A-3vzqA:
undetectable
5om2B-3vzqA:
undetectable		 5om2A-3vzqA:
17.12
5om2B-3vzqA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 3vzq ACETOACETYL-COA
REDUCTASE
(Cupriavidus
necator) 		5 / 12 LEU A  85
GLY A  10
GLY A  33
ILE A  19
ILE A 138
 None
 1.00A 6ecxA-3vzqA:
5.4		 6ecxA-3vzqA:
20.46