SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3vzx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		4 / 6 TYR A  79
CYH A  62
ASP A  77
GLY A  75
 None
MG  A 701 ( 4.9A)
MG  A 706 ( 3.9A)
MG  A 705 ( 4.9A)
 1.15A 1ekjC-3vzxA:
undetectable
1ekjD-3vzxA:
undetectable		 1ekjC-3vzxA:
22.13
1ekjD-3vzxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		4 / 6 CYH A  62
ASP A  77
GLY A  75
TYR A  79
 MG  A 701 ( 4.9A)
MG  A 706 ( 3.9A)
MG  A 705 ( 4.9A)
None
 1.12A 1ekjC-3vzxA:
undetectable
1ekjD-3vzxA:
undetectable		 1ekjC-3vzxA:
22.13
1ekjD-3vzxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		4 / 4 SER A  40
GLY A 187
GLY A 208
LYS A  12
 None
 1.36A 2y4nB-3vzxA:
3.5		 2y4nB-3vzxA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		3 / 3 CYH A 119
PRO A 123
ASP A 141
 None
 0.90A 3hlwB-3vzxA:
undetectable		 3hlwB-3vzxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		3 / 3 CYH A 119
PRO A 123
ASP A 141
 None
 0.90A 4pm5A-3vzxA:
undetectable		 4pm5A-3vzxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		5 / 12 ILE A 205
VAL A 204
GLY A 186
PHE A 184
LEU A 178
 None
 1.15A 5ergB-3vzxA:
undetectable		 5ergB-3vzxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		5 / 12 GLU A 160
LEU A 165
GLY A 208
ILE A 205
ALA A 195
 None
 0.80A 5j7wC-3vzxA:
undetectable		 5j7wC-3vzxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		5 / 12 GLU A 160
LEU A 165
GLY A 208
ILE A 205
ALA A 195
 None
 0.80A 5j7wD-3vzxA:
undetectable		 5j7wD-3vzxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		5 / 12 LEU A  13
ILE A  37
GLY A  38
ASN A  16
MET A  51
 None
None
None
None
CL  A 710 ( 4.0A)
 0.97A 5nfjB-3vzxA:
undetectable		 5nfjB-3vzxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3vzx HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Bacillus
subtilis) 		5 / 12 LEU A  13
ILE A  37
GLY A  38
ASN A  16
MET A  51
 None
None
None
None
CL  A 710 ( 4.0A)
 1.00A 5nfjC-3vzxA:
undetectable		 5nfjC-3vzxA:
20.08