SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		4 / 8 MET A   1
GLU A 181
ASP A 204
ARG A   8
 None
 1.13A 1dtlA-3w01A:
undetectable		 1dtlA-3w01A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 PHE A 115
LEU A 155
ILE A 114
VAL A 113
ALA A  -2
 None
 1.30A 2g72B-3w01A:
undetectable		 2g72B-3w01A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 ASP A  23
ILE A  27
ILE A 212
ILE A  37
LEU A  60
 None
 0.98A 2o4nA-3w01A:
undetectable		 2o4nA-3w01A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 11 ILE A 207
MET A  36
PRO A  82
ILE A   4
THR A  32
 None
 1.07A 3clbA-3w01A:
undetectable		 3clbA-3w01A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 10 ILE A 207
MET A  36
PRO A  82
ILE A   4
THR A  32
 None
 1.12A 3clbD-3w01A:
undetectable		 3clbD-3w01A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLU A  65
SER A 163
VAL A 120
TYR A 118
TYR A 159
 None
 1.43A 3g0bA-3w01A:
undetectable		 3g0bA-3w01A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLU A  65
SER A 163
VAL A 120
TYR A 159
VAL A 127
 None
 1.37A 3g0bA-3w01A:
undetectable		 3g0bA-3w01A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLU A  65
SER A 163
VAL A 120
TYR A 118
TYR A 159
 None
 1.43A 3g0bC-3w01A:
undetectable		 3g0bC-3w01A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLU A  65
SER A 163
VAL A 120
TYR A 159
VAL A 127
 None
 1.37A 3g0bC-3w01A:
undetectable		 3g0bC-3w01A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLU A  65
SER A 163
VAL A 120
TYR A 118
TYR A 159
 None
 1.43A 3g0bD-3w01A:
undetectable		 3g0bD-3w01A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 12 GLU A  65
SER A 163
VAL A 120
TYR A 159
VAL A 127
 None
 1.40A 3g0bD-3w01A:
undetectable		 3g0bD-3w01A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 11 ILE A 207
MET A  36
PRO A  82
ILE A   4
THR A  32
 None
 1.06A 3hbbC-3w01A:
undetectable		 3hbbC-3w01A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		5 / 10 ILE A 207
MET A  36
PRO A  82
ILE A   4
THR A  32
 None
 1.12A 3hbbD-3w01A:
undetectable		 3hbbD-3w01A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		4 / 8 TYR A  58
SER A  53
LEU A  24
ASP A  21
 None
 1.11A 3lsfH-3w01A:
undetectable		 3lsfH-3w01A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		4 / 6 ALA A 200
ILE A 225
HIS A   9
VAL A 208
 None
 1.06A 3nneG-3w01A:
undetectable		 3nneG-3w01A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		3 / 3 PRO A  82
THR A  83
LEU A 155
 None
 0.54A 3ttrA-3w01A:
undetectable		 3ttrA-3w01A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		4 / 6 TYR A 213
LYS A  17
GLY A  38
LEU A  13
 None
 1.02A 5bphA-3w01A:
undetectable		 5bphA-3w01A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		4 / 6 TYR A 213
LYS A  17
GLY A  38
LEU A  13
 None
 1.00A 5bphD-3w01A:
undetectable		 5bphD-3w01A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE
(Staphylococcus
aureus) 		4 / 6 SER A 176
GLU A 177
GLY A 188
GLY A 167
 None
 0.99A 5cdpA-3w01A:
undetectable
5cdpB-3w01A:
undetectable		 5cdpA-3w01A:
18.97
5cdpB-3w01A:
20.41