SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 8 SER A   3
ILE A 166
GLU A  21
ARG A  13
 None
 0.92A 1meiA-3w08A:
undetectable		 1meiA-3w08A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		5 / 12 HIS A 320
GLY A 154
GLY A 156
VAL A  96
ILE A 280
 None
 0.99A 1zq9B-3w08A:
undetectable		 1zq9B-3w08A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		5 / 12 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.30A 2e7fA-3w08A:
undetectable		 2e7fA-3w08A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		5 / 12 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.28A 2e7fB-3w08A:
undetectable		 2e7fB-3w08A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 8 TYR A  98
ASP A  80
TYR A 278
HIS A  84
 None
 1.32A 2ha2B-3w08A:
undetectable		 2ha2B-3w08A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		5 / 11 LEU A 318
LEU A 316
ARG A 317
PHE A 148
ALA A 224
 HEM  A 501 ( 4.6A)
None
None
None
None
 1.05A 2qjuA-3w08A:
undetectable		 2qjuA-3w08A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		3 / 3 TYR A 319
GLU A 321
THR A  78
 None
 0.86A 2y7hB-3w08A:
undetectable		 2y7hB-3w08A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		3 / 3 SER A 329
GLU A 140
ASP A   6
 None
 0.65A 2zulA-3w08A:
undetectable		 2zulA-3w08A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		3 / 3 SER A 329
GLU A 140
ASP A   6
 None
 0.68A 3dmhA-3w08A:
undetectable		 3dmhA-3w08A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		3 / 3 GLU A 287
GLU A 290
TRP A 186
 None
 1.20A 3hrdA-3w08A:
undetectable
3hrdE-3w08A:
undetectable
3hrdF-3w08A:
undetectable		 3hrdA-3w08A:
20.67
3hrdE-3w08A:
20.67
3hrdF-3w08A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		5 / 12 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.28A 3k13C-3w08A:
undetectable		 3k13C-3w08A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 5 GLU A 168
ARG A  33
LYS A  10
GLU A 167
 None
 1.49A 3tj7C-3w08A:
undetectable		 3tj7C-3w08A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		3 / 3 PHE A 332
SER A 325
SER A 135
 None
 0.80A 3ufgB-3w08A:
undetectable		 3ufgB-3w08A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 8 TRP A 117
VAL A 114
TRP A 108
PHE A  70
 None
 1.24A 3v35A-3w08A:
undetectable		 3v35A-3w08A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 7 TYR A 278
VAL A 276
ASN A 266
GLU A 321
 None
 1.14A 4a97H-3w08A:
undetectable		 4a97H-3w08A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		5 / 12 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.29A 4djfA-3w08A:
undetectable		 4djfA-3w08A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 7 PHE A 131
TYR A 334
ILE A 208
HIS A 282
 None
 1.13A 4g5jA-3w08A:
undetectable		 4g5jA-3w08A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 5 GLU A  21
TYR A  23
GLU A 167
GLU A 168
 None
 1.23A 4r87E-3w08A:
undetectable		 4r87E-3w08A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 6 GLU A  21
TYR A  23
GLU A 167
GLU A 168
 None
 1.30A 4r87H-3w08A:
undetectable		 4r87H-3w08A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 7 GLU A  21
TYR A  23
GLU A 167
GLU A 168
 None
 1.21A 4r87J-3w08A:
undetectable
4r87L-3w08A:
undetectable		 4r87J-3w08A:
19.54
4r87L-3w08A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		3 / 3 SER A 325
SER A 323
PHE A 332
 None
 0.87A 5mugA-3w08A:
undetectable		 5mugA-3w08A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 7 SER A 174
GLY A 173
ARG A 178
LEU A 145
 HEM  A 501 (-3.1A)
HEM  A 501 (-3.7A)
HEM  A 501 ( 4.3A)
None
 1.05A 6btxA-3w08A:
undetectable		 6btxA-3w08A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3w08 ALDOXIME DEHYDRATASE
(Pseudomonas
chlororaphis) 		4 / 7 ILE A  66
TRP A  99
HIS A  79
VAL A  95
 None
 1.10A 6j20A-3w08A:
undetectable		 6j20A-3w08A:
21.30