SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w0f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_1
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 4 SER A 141
SER A 144
LEU A 138
PHE A  85
 None
 1.28A 1r5lA-3w0fA:
undetectable		 1r5lA-3w0fA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 6 ILE A 105
TYR A  74
MET A  86
LEU A  84
 IOD  A 305 ( 4.3A)
None
None
None
 0.98A 2einN-3w0fA:
undetectable
2einW-3w0fA:
undetectable		 2einN-3w0fA:
20.08
2einW-3w0fA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 5 VAL A  27
VAL A 122
GLN A  22
ARG A 126
 None
 1.33A 3bjwH-3w0fA:
undetectable		 3bjwH-3w0fA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 5 VAL A  27
VAL A 122
GLN A  22
ARG A 126
 None
 1.19A 3bjwB-3w0fA:
undetectable		 3bjwB-3w0fA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		5 / 10 TYR A  74
ILE A 105
ILE A  14
GLY A  76
LEU A 124
 None
IOD  A 305 ( 4.3A)
None
IOD  A 302 (-3.4A)
None
 1.25A 3elzC-3w0fA:
undetectable		 3elzC-3w0fA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		5 / 12 LEU A   9
ASN A  10
GLY A  11
VAL A  77
ILE A 105
 None
None
None
IOD  A 302 (-4.6A)
IOD  A 305 ( 4.3A)
 1.35A 3h52A-3w0fA:
undetectable		 3h52A-3w0fA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 5 HIS A 246
CYH A 236
ILE A 243
LEU A 232
 None
 1.40A 3qpkA-3w0fA:
undetectable		 3qpkA-3w0fA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 5 LEU A  80
GLY A  81
PHE A  85
ARG A 147
 None
 1.07A 3smtA-3w0fA:
undetectable		 3smtA-3w0fA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 6 ILE A 105
TYR A  74
MET A  86
LEU A  84
 IOD  A 305 ( 4.3A)
None
None
None
 1.02A 3wg7N-3w0fA:
undetectable
3wg7W-3w0fA:
undetectable		 3wg7N-3w0fA:
20.08
3wg7W-3w0fA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 5 PHE A 131
ILE A  14
GLY A  11
THR A  79
 None
 0.83A 4ejjC-3w0fA:
undetectable		 4ejjC-3w0fA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		5 / 12 PHE A  69
LEU A  66
GLY A  29
LEU A 120
VAL A 136
 None
 1.01A 4wnwB-3w0fA:
undetectable		 4wnwB-3w0fA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 6 ARG A 176
ARG A 186
VAL A 181
ASP A 184
 None
 1.37A 4xqeA-3w0fA:
undetectable		 4xqeA-3w0fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 6 ARG A 176
ARG A 186
VAL A 181
ASP A 184
 None
 1.36A 4xqeB-3w0fA:
undetectable		 4xqeB-3w0fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		4 / 5 ARG A 227
PRO A   5
ILE A 156
ASP A 155
 None
 1.27A 4z4hA-3w0fA:
undetectable		 4z4hA-3w0fA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		5 / 12 GLY A 204
SER A 203
ASN A 197
LEU A 182
LEU A 178
 None
 1.23A 5nwwA-3w0fA:
undetectable		 5nwwA-3w0fA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 3w0f ENDONUCLEASE 8-LIKE
3
(Mus
musculus) 		5 / 12 THR A  79
LEU A  84
TYR A  74
ILE A 105
GLU A  12
 None
None
None
IOD  A 305 ( 4.3A)
None
 1.47A 5w8aA-3w0fA:
undetectable		 5w8aA-3w0fA:
20.70