SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 10 ALA A  86
LEU A  83
ILE A 173
HIS A 151
LEU A 154
 None
 1.38A 1a52A-3w0kA:
undetectable		 1a52A-3w0kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 10 ALA A  86
LEU A  83
ILE A 173
HIS A 151
LEU A 154
 None
 1.37A 1a52B-3w0kA:
undetectable		 1a52B-3w0kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 9 ALA A  86
LEU A  83
ILE A 173
HIS A 151
LEU A 154
 None
 1.50A 1ereB-3w0kA:
undetectable		 1ereB-3w0kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 9 ALA A  86
LEU A  83
ILE A 173
HIS A 151
LEU A 154
 None
 1.47A 1ereD-3w0kA:
undetectable		 1ereD-3w0kA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		4 / 6 LEU A 280
ASP A 276
GLU A 283
ARG A 272
 None
 0.97A 1mt1A-3w0kA:
undetectable
1mt1F-3w0kA:
undetectable		 1mt1A-3w0kA:
12.54
1mt1F-3w0kA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		4 / 5 GLU A 283
ARG A 272
LEU A 280
ASP A 276
 None
 1.06A 1n13B-3w0kA:
undetectable
1n13C-3w0kA:
undetectable		 1n13B-3w0kA:
15.24
1n13C-3w0kA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		4 / 7 LEU A 280
ASP A 276
GLU A 283
ARG A 272
 None
 1.06A 1n13I-3w0kA:
undetectable
1n13L-3w0kA:
undetectable		 1n13I-3w0kA:
12.54
1n13L-3w0kA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 12 PHE A  30
LEU A  28
ALA A  27
LEU A 322
PHE A  36
 None
 1.22A 1og5A-3w0kA:
undetectable		 1og5A-3w0kA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 LYS A  59
TYR A 113
PRO A  57
 None
 1.35A 2j9cC-3w0kA:
undetectable		 2j9cC-3w0kA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 11 ASN A 136
GLU A 137
TYR A 198
GLU A 258
TRP A 291
 TRS  A 401 (-3.0A)
TRS  A 401 (-2.7A)
TRS  A 401 ( 4.9A)
TRS  A 401 (-2.8A)
TRS  A 401 (-3.6A)
 0.79A 2v3dB-3w0kA:
16.1		 2v3dB-3w0kA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 12 GLN A   9
VAL A  43
LEU A  81
CYH A  80
PHE A  38
 None
 1.39A 3mnpA-3w0kA:
undetectable		 3mnpA-3w0kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 ASN A   7
TRP A 291
ASP A 133
 None
TRS  A 401 (-3.6A)
None
 1.31A 4a7tA-3w0kA:
undetectable
4a7tF-3w0kA:
undetectable		 4a7tA-3w0kA:
18.97
4a7tF-3w0kA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 PHE A 111
ASP A 109
ARG A 157
 None
 0.76A 4eahF-3w0kA:
undetectable		 4eahF-3w0kA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 PHE A 111
ASP A 109
ARG A 157
 None
 0.75A 4eahG-3w0kA:
undetectable		 4eahG-3w0kA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 ARG A  75
LYS A  26
LYS A  25
 None
 1.38A 4k50A-3w0kA:
undetectable		 4k50A-3w0kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 ARG A  75
LYS A  26
LYS A  25
 None
 1.35A 4k50E-3w0kA:
undetectable		 4k50E-3w0kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 ARG A  75
LYS A  26
LYS A  25
 None
 1.35A 4k50I-3w0kA:
undetectable		 4k50I-3w0kA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 12 LEU A  31
ALA A  32
PHE A  30
ILE A 299
LEU A 322
 None
 0.95A 4psyA-3w0kA:
undetectable		 4psyA-3w0kA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 12 GLY A 190
LEU A 189
ASP A 133
VAL A 159
THR A 158
 None
 1.07A 4wnwA-3w0kA:
undetectable		 4wnwA-3w0kA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 ASP A  44
ARG A  85
TYR A  45
 None
 1.01A 5a7mA-3w0kA:
4.2		 5a7mA-3w0kA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		3 / 3 ASP A  44
ARG A  85
TYR A  45
 None
 0.98A 5a7mB-3w0kA:
3.8		 5a7mB-3w0kA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		4 / 6 TYR A 198
TYR A 241
GLY A 178
GLU A 137
 TRS  A 401 ( 4.9A)
None
None
TRS  A 401 (-2.7A)
 1.26A 5emlA-3w0kA:
3.9		 5emlA-3w0kA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 9 GLN A 108
PHE A 111
GLU A 116
LEU A 134
ILE A 155
 None
 1.49A 5i73A-3w0kA:
undetectable		 5i73A-3w0kA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE
(Caldanaerobius
polysaccharolyti
cus) 		5 / 10 ALA A  86
LEU A  83
ILE A 173
HIS A 151
LEU A 154
 None
 1.42A 6cbzB-3w0kA:
undetectable		 6cbzB-3w0kA:
11.98