SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w0l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 3w0l GLUCOKINASE
(Xenopus
laevis) 		5 / 9 HIS A 409
ILE A 344
GLU A 365
SER A 368
GLY A 292
 None
 1.45A 1dwcH-3w0lA:
undetectable		 1dwcH-3w0lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		5 / 12 ALA A 371
GLY A 292
GLY A 288
GLY A 287
LEU A 299
 None
 0.78A 1eizA-3w0lA:
undetectable		 1eizA-3w0lA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		5 / 12 ALA A 371
GLY A 292
GLY A 288
GLY A 287
LEU A 299
 None
 0.79A 1ej0A-3w0lA:
undetectable		 1ej0A-3w0lA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		5 / 12 ILE A 432
PHE A 431
GLY A 400
LEU A 421
LEU A 383
 None
 1.30A 1fm6X-3w0lA:
undetectable		 1fm6X-3w0lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		5 / 10 ILE A 218
GLY A 222
THR A 221
GLU A 283
ARG A 440
 None
None
SO4  A 501 (-4.1A)
None
SO4  A 501 (-3.4A)
 1.43A 1i7qC-3w0lA:
undetectable		 1i7qC-3w0lA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 GLY B 262
GLY B 263
LEU B 113
ILE B 268
LEU B 269
 None
 0.87A 1mx1D-3w0lB:
2.3		 1mx1D-3w0lB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 LEU B 485
GLY B 333
GLY B 338
TYR B 330
LEU B 323
 None
 1.23A 1p91A-3w0lB:
undetectable		 1p91A-3w0lB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 10 LEU B 245
ILE B  30
GLY B 250
ILE B  60
VAL B 206
 None
 0.93A 1sdtA-3w0lB:
undetectable		 1sdtA-3w0lB:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		3 / 3 MET A  30
ASN A 224
GLN A 280
 None
 0.89A 1xoqB-3w0lA:
undetectable		 1xoqB-3w0lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 5 ILE A 373
PHE A 412
PHE A 416
ILE A 286
 None
 1.08A 2hjhA-3w0lA:
undetectable		 2hjhA-3w0lA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		5 / 9 LEU A 342
ILE A 344
ILE A 331
VAL A 360
ALA A 352
 None
 1.16A 2m9qA-3w0lA:
undetectable		 2m9qA-3w0lA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		3 / 3 LEU A  51
PRO A  52
ARG A 179
 None
 0.64A 2qd4B-3w0lA:
undetectable		 2qd4B-3w0lA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 7 TYR A 208
ILE A 204
GLY A  65
LEU A 137
 None
 0.84A 2vctD-3w0lA:
undetectable		 2vctD-3w0lA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 10 PRO B 251
GLY B 250
LEU B  21
ARG B  73
GLY B  17
 None
 1.40A 2vl2A-3w0lB:
undetectable
2vl2C-3w0lB:
undetectable		 2vl2A-3w0lB:
16.64
2vl2C-3w0lB:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		3 / 3 HIS B  70
GLU B  64
HIS B  72
 None
 0.64A 3ba0A-3w0lB:
undetectable		 3ba0A-3w0lB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 4 SER A 404
GLY A 403
GLY A 288
GLY A 222
 SO4  A 501 (-2.7A)
SO4  A 501 (-3.3A)
None
None
 0.89A 3bogB-3w0lA:
undetectable
3bogD-3w0lA:
undetectable		 3bogB-3w0lA:
undetectable
3bogD-3w0lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 10 ILE B 386
ASP B 390
VAL B 146
ILE B 145
ILE B 370
 None
 1.37A 3kpbD-3w0lB:
undetectable		 3kpbD-3w0lB:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		3 / 3 THR B 147
SER B 144
ARG B 143
 None
 0.64A 3phnA-3w0lB:
undetectable		 3phnA-3w0lB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 5 VAL A 192
ARG A 179
LYS A 133
LYS A 136
 None
 1.33A 3rv5A-3w0lA:
undetectable
3rv5B-3w0lA:
undetectable		 3rv5A-3w0lA:
9.61
3rv5B-3w0lA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		3 / 3 HIS A 358
SER A 366
GLU A 365
 None
 0.92A 3s8pA-3w0lA:
undetectable		 3s8pA-3w0lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 LEU B 116
ILE B 386
GLY B 361
ILE B 331
THR B 336
 None
 1.15A 3spkA-3w0lB:
undetectable		 3spkA-3w0lB:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 6 CYH A 226
ASN A 247
CYH A 245
ILE A 204
 None
 1.37A 3w9tB-3w0lA:
undetectable		 3w9tB-3w0lA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 CYH B 167
LEU B 104
ILE B 176
LEU B 274
LEU B 125
 None
 1.19A 4dm8A-3w0lB:
undetectable		 4dm8A-3w0lB:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		3 / 3 LEU B 485
LYS B 482
THR B 481
 None
 0.45A 4lj0A-3w0lB:
undetectable		 4lj0A-3w0lB:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 GLU B  66
SER B  76
ARG B  73
GLU B  64
GLU B  20
 None
 1.28A 4mx0A-3w0lB:
undetectable		 4mx0A-3w0lB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 5 GLY B 457
ILE B 484
LEU B 406
LEU B 415
 None
 0.84A 4o8fA-3w0lB:
undetectable		 4o8fA-3w0lB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 7 THR B 109
LEU B 514
ASN B 511
SER B 144
 F6R  B 701 (-3.7A)
None
None
None
 1.05A 4pfjA-3w0lB:
3.3		 4pfjA-3w0lB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 GLY B 341
ILE B 370
GLY B 365
GLY B 361
ILE B 342
 None
 1.03A 4q5mA-3w0lB:
undetectable		 4q5mA-3w0lB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 GLY B 108
ILE B 145
SER B 144
ILE B 178
ALA B 114
 F6R  B 701 (-3.6A)
None
None
None
None
 1.00A 4qtuD-3w0lB:
undetectable		 4qtuD-3w0lB:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 GLY B 441
THR B 439
ALA B 438
THR B 459
ASP B 412
 None
 1.47A 4qvnH-3w0lB:
undetectable
4qvnI-3w0lB:
0.0		 4qvnH-3w0lB:
17.80
4qvnI-3w0lB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 10 GLY B 441
THR B 439
ALA B 438
THR B 459
ASP B 412
 None
 1.48A 4qvnV-3w0lB:
undetectable
4qvnW-3w0lB:
0.9		 4qvnV-3w0lB:
17.80
4qvnW-3w0lB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 GLY B 441
THR B 439
ALA B 438
THR B 459
ASP B 412
 None
 1.47A 4qvqH-3w0lB:
undetectable
4qvqI-3w0lB:
undetectable		 4qvqH-3w0lB:
17.80
4qvqI-3w0lB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 GLY B 441
THR B 439
ALA B 438
THR B 459
ASP B 412
 None
 1.47A 4qvqV-3w0lB:
undetectable
4qvqW-3w0lB:
undetectable		 4qvqV-3w0lB:
17.80
4qvqW-3w0lB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 GLY B 441
THR B 439
ALA B 438
THR B 459
ASP B 412
 None
 1.48A 4qwuH-3w0lB:
undetectable
4qwuI-3w0lB:
undetectable		 4qwuH-3w0lB:
17.80
4qwuI-3w0lB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 11 GLY B 441
THR B 439
ALA B 438
THR B 459
ASP B 412
 None
 1.48A 4qwuV-3w0lB:
undetectable
4qwuW-3w0lB:
undetectable		 4qwuV-3w0lB:
17.80
4qwuW-3w0lB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 VAL B 572
SER B 586
ILE B 590
SER B 602
VAL B 505
 None
 1.41A 4rujA-3w0lB:
undetectable		 4rujA-3w0lB:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 8 PHE A 141
ALA A 194
LEU A 139
GLY A 140
 None
 0.97A 4xk8a-3w0lA:
undetectable		 4xk8a-3w0lA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 GLY B 177
ILE B 386
GLY B 361
GLY B 341
LEU B 116
 None
 1.11A 5eqbA-3w0lB:
undetectable		 5eqbA-3w0lB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 7 VAL A 367
SER A 368
ALA A 371
GLY A 287
 None
 0.92A 5fpdA-3w0lA:
4.8		 5fpdA-3w0lA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 7 VAL A 367
SER A 368
ALA A 371
GLY A 288
 None
 0.71A 5fpdA-3w0lA:
4.8		 5fpdA-3w0lA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		3 / 3 PRO B 453
LEU B 406
SER B 430
 None
 0.81A 5fsaB-3w0lB:
0.4		 5fsaB-3w0lB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 LEU B  49
VAL B 488
GLY B 491
ALA B 492
LEU B 323
 None
 1.13A 5ikqB-3w0lB:
3.3		 5ikqB-3w0lB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		6 / 12 VAL B 359
LEU B  49
VAL B 488
GLY B 491
ALA B 492
LEU B 323
 None
 1.48A 5iktA-3w0lB:
0.0		 5iktA-3w0lB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 7 ILE B 331
ASP B 486
LYS B 482
SER B 490
 None
 1.48A 5nr3A-3w0lB:
undetectable		 5nr3A-3w0lB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 5 LEU B  49
LEU B  52
MET B 260
TYR B 493
 None
 1.36A 5uc3A-3w0lB:
3.9		 5uc3A-3w0lB:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 8 ARG A 370
ASP A 255
LEU A 281
GLY A 254
 None
 0.83A 5x5qF-3w0lA:
undetectable		 5x5qF-3w0lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 ILE B 583
VAL B 536
LEU B 537
VAL B 505
LEU B 522
 None
 1.17A 6ajiA-3w0lB:
undetectable		 6ajiA-3w0lB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 7 ILE B  30
VAL B 249
ALA B 265
THR B 266
 None
 0.91A 6cduC-3w0lB:
3.7
6cduD-3w0lB:
3.7		 6cduC-3w0lB:
20.34
6cduD-3w0lB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 7 ALA B 265
THR B 266
ILE B  30
VAL B 249
 None
 0.96A 6cduF-3w0lB:
3.7
6cduJ-3w0lB:
2.4		 6cduF-3w0lB:
20.34
6cduJ-3w0lB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 GLY B 361
GLY B 341
SER B 387
PHE B 362
VAL B 359
 None
 1.29A 6clxA-3w0lB:
undetectable		 6clxA-3w0lB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		5 / 12 GLU B 347
PRO B 350
ASN B 510
GLU B 153
ASP B 154
 F6R  B 701 (-3.2A)
None
None
F6R  B 701 (-3.8A)
None
 1.31A 6ekuA-3w0lB:
undetectable		 6ekuA-3w0lB:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3w0l GLUCOKINASE
(Xenopus
laevis) 		4 / 6 ASN A 197
VAL A 200
VAL A 246
THR A 248
 None
 1.37A 6f32B-3w0lA:
undetectable		 6f32B-3w0lA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 5 GLY B 108
THR B 109
SER B 257
SER B 258
 F6R  B 701 (-3.6A)
F6R  B 701 (-3.7A)
F6R  B 701 ( 4.7A)
F6R  B 701 (-3.4A)
 1.03A 6jmjA-3w0lB:
undetectable		 6jmjA-3w0lB:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3w0l GLUCOKINASE
REGULATORY PROTEIN
(Xenopus
laevis) 		4 / 6 GLY B 108
THR B 109
SER B 257
SER B 258
 F6R  B 701 (-3.6A)
F6R  B 701 (-3.7A)
F6R  B 701 ( 4.7A)
F6R  B 701 (-3.4A)
 1.01A 6jogA-3w0lB:
undetectable		 6jogA-3w0lB:
14.13