SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 LEU A 267
PHE A 234
LEU A 274
LEU A 271
 None
 0.87A 1e7cA-3w0sA:
undetectable		 1e7cA-3w0sA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		3 / 3 ALA A 123
HIS A 193
VAL A 195
 None
 0.47A 1lqtB-3w0sA:
undetectable		 1lqtB-3w0sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		3 / 3 ALA A 123
HIS A 193
VAL A 195
 None
 0.48A 1lquB-3w0sA:
undetectable		 1lquB-3w0sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		3 / 3 ASN A 231
TRP A 235
GLN A 245
 HY0  A 401 (-3.3A)
HY0  A 401 (-3.5A)
None
 1.13A 1xoqA-3w0sA:
undetectable		 1xoqA-3w0sA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 5 ILE A 296
LEU A 271
ALA A 177
GLU A 180
 None
 1.30A 1xvaA-3w0sA:
undetectable
1xvaB-3w0sA:
undetectable		 1xvaA-3w0sA:
21.51
1xvaB-3w0sA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		3 / 3 ASN A  51
ARG A  49
ASP A 198
 None
None
HY0  A 401 (-2.7A)
 0.97A 2qe6B-3w0sA:
undetectable		 2qe6B-3w0sA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		3 / 3 ARG A 210
GLN A 113
PRO A 114
 None
 0.77A 2qhfA-3w0sA:
undetectable		 2qhfA-3w0sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 ARG A 252
GLN A 245
HIS A 253
GLN A 226
 None
 1.29A 2vxaA-3w0sA:
1.6
2vxaC-3w0sA:
1.6
2vxaE-3w0sA:
1.6		 2vxaA-3w0sA:
12.07
2vxaC-3w0sA:
12.07
2vxaE-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 GLN A 245
ARG A 252
HIS A 253
GLN A 226
 None
 1.30A 2vxaA-3w0sA:
1.6
2vxaB-3w0sA:
1.6
2vxaK-3w0sA:
1.6		 2vxaA-3w0sA:
12.07
2vxaB-3w0sA:
12.07
2vxaK-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 GLN A 245
ARG A 252
HIS A 253
GLN A 226
 None
 1.32A 2vxaB-3w0sA:
1.6
2vxaC-3w0sA:
1.6
2vxaG-3w0sA:
1.6		 2vxaB-3w0sA:
12.07
2vxaC-3w0sA:
12.07
2vxaG-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 ARG A 252
GLN A 245
HIS A 253
GLN A 226
 None
 1.31A 2vxaD-3w0sA:
1.6
2vxaF-3w0sA:
1.6
2vxaI-3w0sA:
1.6		 2vxaD-3w0sA:
12.07
2vxaF-3w0sA:
12.07
2vxaI-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 GLN A 245
ARG A 252
HIS A 253
GLN A 226
 None
 1.31A 2vxaD-3w0sA:
1.6
2vxaE-3w0sA:
1.6
2vxaL-3w0sA:
1.6		 2vxaD-3w0sA:
12.07
2vxaE-3w0sA:
12.07
2vxaL-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 HIS A 253
GLN A 226
ARG A 252
GLN A 245
 None
 1.31A 2vxaF-3w0sA:
1.6
2vxaG-3w0sA:
1.6
2vxaI-3w0sA:
1.6		 2vxaF-3w0sA:
12.07
2vxaG-3w0sA:
12.07
2vxaI-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 HIS A 253
GLN A 226
GLN A 245
ARG A 252
 None
 1.32A 2vxaB-3w0sA:
1.6
2vxaG-3w0sA:
1.6
2vxaH-3w0sA:
1.6		 2vxaB-3w0sA:
12.07
2vxaG-3w0sA:
12.07
2vxaH-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 GLN A 245
ARG A 252
HIS A 253
GLN A 226
 None
 1.30A 2vxaH-3w0sA:
1.6
2vxaI-3w0sA:
1.6
2vxaJ-3w0sA:
undetectable		 2vxaH-3w0sA:
12.07
2vxaI-3w0sA:
12.07
2vxaJ-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 HIS A 253
GLN A 226
ARG A 252
GLN A 245
 None
 1.31A 2vxaD-3w0sA:
1.6
2vxaJ-3w0sA:
undetectable
2vxaL-3w0sA:
1.6		 2vxaD-3w0sA:
12.07
2vxaJ-3w0sA:
12.07
2vxaL-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 HIS A 253
GLN A 226
GLN A 245
ARG A 252
 None
 1.32A 2vxaH-3w0sA:
1.6
2vxaJ-3w0sA:
undetectable
2vxaK-3w0sA:
1.6		 2vxaH-3w0sA:
12.07
2vxaJ-3w0sA:
12.07
2vxaK-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 HIS A 253
GLN A 226
GLN A 245
ARG A 252
 None
 1.32A 2vxaA-3w0sA:
1.6
2vxaK-3w0sA:
1.6
2vxaL-3w0sA:
1.6		 2vxaA-3w0sA:
12.07
2vxaK-3w0sA:
12.07
2vxaL-3w0sA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.20A 3dqtA-3w0sA:
undetectable
3dqtB-3w0sA:
undetectable		 3dqtA-3w0sA:
20.37
3dqtB-3w0sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 PRO A 114
ALA A 118
ALA A 121
ILE A 211
 None
 0.84A 3dtuC-3w0sA:
undetectable
3dtuD-3w0sA:
undetectable		 3dtuC-3w0sA:
19.12
3dtuD-3w0sA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.27A 3jx1A-3w0sA:
undetectable
3jx1B-3w0sA:
undetectable		 3jx1A-3w0sA:
19.50
3jx1B-3w0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.23A 3n5tA-3w0sA:
undetectable
3n5tB-3w0sA:
undetectable		 3n5tA-3w0sA:
21.96
3n5tB-3w0sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.24A 3n61A-3w0sA:
undetectable
3n61B-3w0sA:
undetectable		 3n61A-3w0sA:
19.50
3n61B-3w0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.25A 3nlyA-3w0sA:
undetectable
3nlyB-3w0sA:
undetectable		 3nlyA-3w0sA:
19.50
3nlyB-3w0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 6 THR A 206
ILE A 232
ASP A 102
THR A 212
 None
 1.07A 3q70A-3w0sA:
undetectable		 3q70A-3w0sA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.22A 3rqlA-3w0sA:
undetectable
3rqlB-3w0sA:
undetectable		 3rqlA-3w0sA:
19.50
3rqlB-3w0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 4 ASN A 203
SER A  69
LEU A  72
THR A  99
 ANP  A 402 ( 4.6A)
None
None
None
 1.40A 4an2A-3w0sA:
6.6		 4an2A-3w0sA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.23A 4capA-3w0sA:
undetectable
4capB-3w0sA:
undetectable		 4capA-3w0sA:
19.50
4capB-3w0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.22A 4cx7A-3w0sA:
undetectable
4cx7B-3w0sA:
undetectable		 4cx7A-3w0sA:
21.70
4cx7B-3w0sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.17A 4cx7C-3w0sA:
undetectable
4cx7D-3w0sA:
undetectable		 4cx7C-3w0sA:
21.70
4cx7D-3w0sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.19A 4d32A-3w0sA:
undetectable
4d32B-3w0sA:
undetectable		 4d32A-3w0sA:
19.50
4d32B-3w0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.16A 4k5jA-3w0sA:
undetectable
4k5jB-3w0sA:
undetectable		 4k5jA-3w0sA:
21.96
4k5jB-3w0sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.23A 4v3yA-3w0sA:
undetectable
4v3yB-3w0sA:
undetectable		 4v3yA-3w0sA:
19.50
4v3yB-3w0sA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.16A 5adlA-3w0sA:
undetectable
5adlB-3w0sA:
undetectable		 5adlA-3w0sA:
21.96
5adlB-3w0sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.17A 5fj3A-3w0sA:
undetectable
5fj3B-3w0sA:
undetectable		 5fj3A-3w0sA:
21.96
5fj3B-3w0sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		5 / 10 ALA A 118
GLY A 200
ILE A 232
VAL A 195
ILE A 122
 None
 1.06A 5kr1A-3w0sA:
undetectable		 5kr1A-3w0sA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		3 / 3 VAL A 195
TYR A 227
GLN A 226
 None
 0.75A 5qgtA-3w0sA:
undetectable		 5qgtA-3w0sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 8 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.21A 5uo7A-3w0sA:
undetectable
5uo7B-3w0sA:
undetectable		 5uo7A-3w0sA:
19.95
5uo7B-3w0sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 6 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.16A 5uo8A-3w0sA:
undetectable
5uo8B-3w0sA:
undetectable		 5uo8A-3w0sA:
22.49
5uo8B-3w0sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.18A 5vv7A-3w0sA:
undetectable
5vv7B-3w0sA:
undetectable		 5vv7A-3w0sA:
21.96
5vv7B-3w0sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.19A 5vvnA-3w0sA:
undetectable
5vvnB-3w0sA:
undetectable		 5vvnA-3w0sA:
21.96
5vvnB-3w0sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 SER A 218
TRP A 217
PHE A 136
GLU A 219
 HY0  A 401 (-3.5A)
None
None
HY0  A 401 (-4.0A)
 1.16A 6av6A-3w0sA:
undetectable
6av6B-3w0sA:
undetectable		 6av6A-3w0sA:
13.82
6av6B-3w0sA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3w0s HYGROMYCIN-B
4-O-KINASE
(Escherichia
coli) 		4 / 7 PHE A 136
GLU A 219
SER A 218
TRP A 217
 None
HY0  A 401 (-4.0A)
HY0  A 401 (-3.5A)
None
 1.14A 6av6C-3w0sA:
0.0
6av6D-3w0sA:
undetectable		 6av6C-3w0sA:
13.82
6av6D-3w0sA:
13.82