SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w15'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 8 PHE A   9
GLY A  11
VAL A  78
PHE A  41
 None
 1.00A 1gsfA-3w15A:
undetectable		 1gsfA-3w15A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 8 PHE A   9
GLY A  11
VAL A  78
PHE A  41
 None
 1.00A 1gsfB-3w15A:
undetectable		 1gsfB-3w15A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 8 PHE A   9
GLY A  11
VAL A  78
PHE A  41
 None
 1.00A 1gsfC-3w15A:
undetectable		 1gsfC-3w15A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 8 PHE A   9
GLY A  11
VAL A  78
PHE A  41
 None
 1.00A 1gsfD-3w15A:
undetectable		 1gsfD-3w15A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 190
VAL A 177
TYR A  12
CYH A 110
 None
None
None
MG  A 403 (-4.6A)
 1.23A 1t46A-3w15A:
undetectable		 1t46A-3w15A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 PHE A   9
GLY A   8
GLY A  11
GLY A 366
LEU A  66
 None
 0.95A 2nxeB-3w15A:
undetectable		 2nxeB-3w15A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 126
GLU A 102
HIS A 103
SER A 139
 None
 1.07A 2q0iA-3w15A:
undetectable		 2q0iA-3w15A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 PHE A   9
GLY A   8
GLY A  11
GLY A 366
LEU A  66
 None
 0.95A 2zbpA-3w15A:
undetectable		 2zbpA-3w15A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 GLN A  80
GLY A  81
GLY A  29
GLY A  38
LEU A  40
 None
 1.01A 3kkzB-3w15A:
undetectable		 3kkzB-3w15A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 216
ALA A 223
GLY A 240
GLY A 220
SER A 219
 NO3  A 401 (-4.4A)
None
None
None
None
 0.99A 3ou6A-3w15A:
undetectable		 3ou6A-3w15A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 216
ALA A 223
GLY A 240
GLY A 220
SER A 219
 NO3  A 401 (-4.4A)
None
None
None
None
 1.00A 3ou6B-3w15A:
undetectable		 3ou6B-3w15A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 216
ALA A 223
GLY A 240
GLY A 220
SER A 219
 NO3  A 401 (-4.4A)
None
None
None
None
 1.01A 3ou7A-3w15A:
undetectable		 3ou7A-3w15A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 216
ALA A 223
GLY A 240
GLY A 220
SER A 219
 NO3  A 401 (-4.4A)
None
None
None
None
 0.99A 3ou7B-3w15A:
undetectable		 3ou7B-3w15A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 216
ALA A 223
GLY A 240
GLY A 220
SER A 219
 NO3  A 401 (-4.4A)
None
None
None
None
 0.97A 3ou7D-3w15A:
undetectable		 3ou7D-3w15A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 PHE A  64
GLY A  29
GLY A  11
ALA A  27
GLY A  38
 None
 1.05A 3tegA-3w15A:
undetectable		 3tegA-3w15A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 146
ASN A 214
GLY A 220
THR A 151
 None
 1.06A 4l1aB-3w15A:
undetectable		 4l1aB-3w15A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 291
GLN A  15
THR A 290
 None
 1.03A 4m2xA-3w15A:
undetectable		 4m2xA-3w15A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 349
HIS A 341
VAL A  14
VAL A  26
LEU A 368
 None
 1.50A 4yhaC-3w15A:
undetectable		 4yhaC-3w15A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 293
GLU A  73
ALA A  25
LEU A  66
 None
 1.00A 5igiA-3w15A:
undetectable		 5igiA-3w15A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 SER A 194
ASN A 214
GLN A 212
LEU A 201
LEU A 191
 None
 1.38A 5nvpA-3w15A:
0.0		 5nvpA-3w15A:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR
(Saccharomyces
cerevisiae) 		5 / 12 GLN A  60
GLY A  81
ALA A  28
ALA A  27
VAL A  26
 None
 0.92A 6c2mC-3w15A:
undetectable		 6c2mC-3w15A:
11.92