SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w1g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 LEU A 152
LEU A 221
ILE A 203
LEU A 194
LEU A 186
 None
 0.87A 1errB-3w1gA:
undetectable		 1errB-3w1gA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 GLN A 301
PHE A 367
MET A 333
ALA A 334
 SO4  A 715 (-4.2A)
ATP  A 701 (-3.6A)
None
SO4  A 715 ( 4.5A)
 1.33A 1linA-3w1gA:
undetectable		 1linA-3w1gA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 ILE A 203
PRO A  73
LEU A 194
VAL A  14
ASP A  18
 None
 1.50A 1mrlB-3w1gA:
undetectable
1mrlC-3w1gA:
undetectable		 1mrlB-3w1gA:
15.47
1mrlC-3w1gA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 ARG A 585
ILE A 584
LEU A 522
GLY A 519
 None
 0.88A 1rtsB-3w1gA:
undetectable		 1rtsB-3w1gA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 ILE A 556
LEU A 518
ILE A 559
ASP A 463
 None
 0.92A 1yc2E-3w1gA:
undetectable		 1yc2E-3w1gA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 MET A 279
TYR A 290
VAL A 217
ASP A 329
ARG A 278
 None
None
None
None
ATP  A 701 (-4.3A)
 1.33A 2avdB-3w1gA:
undetectable		 2avdB-3w1gA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 ARG A 278
ASP A 368
ASP A 329
TYR A 438
 ATP  A 701 (-4.3A)
None
None
None
 1.08A 2e5dA-3w1gA:
undetectable
2e5dB-3w1gA:
undetectable		 2e5dA-3w1gA:
22.02
2e5dB-3w1gA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 ARG A 385
LEU A 370
PRO A 395
VAL A 366
 None
 1.34A 2hrcA-3w1gA:
undetectable		 2hrcA-3w1gA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		3 / 3 PRO A  66
ASN A 149
ARG A  79
 None
 0.67A 2qeuB-3w1gA:
1.8		 2qeuB-3w1gA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 5 TYR A  82
ILE A 190
LEU A 171
LEU A 174
 None
 1.08A 2zb7A-3w1gA:
undetectable		 2zb7A-3w1gA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 VAL A 206
GLU A  41
VAL A 198
ILE A  26
THR A 202
 None
None
SO4  A 706 (-3.5A)
None
SO4  A 706 (-3.1A)
 1.24A 3dl9A-3w1gA:
undetectable		 3dl9A-3w1gA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 VAL A 369
LEU A 328
LEU A 377
PHE A 319
ILE A 323
 None
 1.23A 3kk6B-3w1gA:
undetectable		 3kk6B-3w1gA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 11 ALA A  90
ILE A  94
LEU A 110
LEU A 107
ALA A 106
 None
 1.25A 3kw2A-3w1gA:
undetectable		 3kw2A-3w1gA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 11 ALA A  90
ILE A  94
LEU A 110
LEU A 107
ALA A 106
 None
 1.28A 3kw2B-3w1gA:
undetectable		 3kw2B-3w1gA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.16A 3lslA-3w1gA:
undetectable
3lslD-3w1gA:
undetectable		 3lslA-3w1gA:
17.51
3lslD-3w1gA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.21A 3lslA-3w1gA:
undetectable
3lslD-3w1gA:
undetectable		 3lslA-3w1gA:
17.51
3lslD-3w1gA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 6 TYR A  82
ASN A 149
LEU A 152
ASP A 153
 None
 1.19A 3lslG-3w1gA:
undetectable		 3lslG-3w1gA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 8 ARG A 293
LEU A 370
ASP A 441
TYR A 438
 SO4  A 709 ( 3.4A)
None
None
None
 1.03A 3qj7A-3w1gA:
undetectable
3qj7D-3w1gA:
undetectable		 3qj7A-3w1gA:
18.55
3qj7D-3w1gA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 GLU A 271
LYS A 273
ARG A 293
VAL A 403
LYS A 449
 ATP  A 701 (-4.2A)
ATP  A 701 (-2.1A)
SO4  A 709 ( 3.4A)
None
SO4  A 709 ( 2.8A)
 1.12A 3qwuA-3w1gA:
10.3		 3qwuA-3w1gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		6 / 12 GLU A 271
LYS A 273
PHE A 367
VAL A 403
LYS A 432
LYS A 449
 ATP  A 701 (-4.2A)
ATP  A 701 (-2.1A)
ATP  A 701 (-3.6A)
None
ATP  A 701 (-3.5A)
SO4  A 709 ( 2.8A)
 1.10A 3qwuA-3w1gA:
10.3		 3qwuA-3w1gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 GLU A 331
PHE A 367
VAL A 403
LYS A 432
LYS A 449
 ATP  A 701 (-3.4A)
ATP  A 701 (-3.6A)
None
ATP  A 701 (-3.5A)
SO4  A 709 ( 2.8A)
 0.81A 3qwuA-3w1gA:
10.3		 3qwuA-3w1gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 11 GLU A 271
LYS A 273
PHE A 367
VAL A 403
LYS A 432
 ATP  A 701 (-4.2A)
ATP  A 701 (-2.1A)
ATP  A 701 (-3.6A)
None
ATP  A 701 (-3.5A)
 0.83A 3qwuB-3w1gA:
5.6		 3qwuB-3w1gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 11 LYS A 273
GLU A 331
PHE A 367
VAL A 403
LYS A 432
 ATP  A 701 (-2.1A)
ATP  A 701 (-3.4A)
ATP  A 701 (-3.6A)
None
ATP  A 701 (-3.5A)
 0.84A 3qwuB-3w1gA:
5.6		 3qwuB-3w1gA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 ILE A 315
TYR A 290
HIS A 282
PHE A 302
 None
 1.11A 4a97H-3w1gA:
undetectable		 4a97H-3w1gA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 SER A  63
TRP A  46
THR A 144
ALA A  67
ASN A 149
 None
 1.39A 4dajA-3w1gA:
0.0		 4dajA-3w1gA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		6 / 11 CYH A 225
LEU A  75
LEU A 221
SER A  63
LEU A 196
ILE A 203
 None
 1.45A 4dm8A-3w1gA:
undetectable		 4dm8A-3w1gA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 8 ARG A 278
ASP A 368
SER A 436
TYR A 438
 ATP  A 701 (-4.3A)
None
None
None
 1.01A 4lv9A-3w1gA:
undetectable
4lv9B-3w1gA:
undetectable		 4lv9A-3w1gA:
21.15
4lv9B-3w1gA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		3 / 3 SER A 498
ALA A 488
VAL A 487
 None
 0.53A 4x1iA-3w1gA:
undetectable		 4x1iA-3w1gA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		3 / 3 ASP A 210
ARG A  40
ARG A  47
 None
 0.95A 4x5iA-3w1gA:
undetectable		 4x5iA-3w1gA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 SER A  63
TRP A  46
THR A 144
ALA A  67
ASN A 149
 None
 1.43A 5dsgA-3w1gA:
undetectable		 5dsgA-3w1gA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		5 / 12 SER A  63
TRP A  46
THR A 144
ALA A  67
ASN A 149
 None
 1.42A 5dsgB-3w1gA:
undetectable		 5dsgB-3w1gA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		3 / 3 ASP A 210
ARG A  40
ARG A  47
 None
 0.74A 5eajB-3w1gA:
undetectable		 5eajB-3w1gA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		3 / 3 SER A 498
ALA A 488
VAL A 487
 None
 0.57A 5eypA-3w1gA:
undetectable		 5eypA-3w1gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 6 ASP A 423
HIS A 482
ILE A 581
TYR A 570
 None
 1.01A 5ih0A-3w1gA:
undetectable		 5ih0A-3w1gA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		3 / 3 HIS A 282
LYS A 289
PHE A 291
 None
 1.40A 5klaA-3w1gA:
undetectable		 5klaA-3w1gA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 7 ASP A 441
PRO A 440
TYR A 438
SER A 292
 None
None
None
SO4  A 703 (-2.3A)
 1.26A 5l1fC-3w1gA:
undetectable		 5l1fC-3w1gA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		3 / 3 TYR A 288
ASP A 284
ASP A 286
 None
 0.73A 5x6yA-3w1gA:
undetectable		 5x6yA-3w1gA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3w1g DNA LIGASE 4
(Homo
sapiens) 		4 / 6 GLY A 446
TRP A 447
ALA A 251
LEU A 250
 None
None
ATP  A 701 ( 4.4A)
None
 1.08A 6fosA-3w1gA:
undetectable		 6fosA-3w1gA:
7.88