SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w1h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 GLU A 406
ARG A 409
ARG A 410
LEU A 402
 None
 0.85A 1cmaA-3w1hA:
undetectable
1cmaB-3w1hA:
undetectable		 1cmaA-3w1hA:
12.53
1cmaB-3w1hA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A 249
SER A 217
GLY A 283
ASP A 284
ILE A 316
 LLP  A 285 ( 3.0A)
LLP  A 285 ( 3.1A)
LLP  A 285 ( 4.4A)
LLP  A 285 ( 4.3A)
None
 1.09A 1jzsA-3w1hA:
undetectable		 1jzsA-3w1hA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 1.04A 1os6A-3w1hA:
undetectable		 1os6A-3w1hA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 7 HIS A 215
ALA A 248
GLY A 281
GLY A 249
ASN A 142
 None
None
None
LLP  A 285 ( 3.0A)
LLP  A 285 ( 4.5A)
 1.47A 2c49B-3w1hA:
undetectable		 2c49B-3w1hA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 LEU A 286
LEU A 253
LEU A 252
ILE A 254
TYR A 331
 LLP  A 285 ( 4.3A)
None
None
None
None
 1.25A 2f7aA-3w1hA:
undetectable		 2f7aA-3w1hA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 294
GLY A 293
GLY A 144
GLY A 251
ALA A 292
 None
 0.98A 2fk8A-3w1hA:
4.0		 2fk8A-3w1hA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 144
ALA A 143
GLY A 249
GLY A 281
ILE A 294
 None
LLP  A 285 ( 3.1A)
LLP  A 285 ( 3.0A)
None
None
 0.81A 2fxeA-3w1hA:
undetectable		 2fxeA-3w1hA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.95A 2q63B-3w1hA:
undetectable		 2q63B-3w1hA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 ALA A 414
THR A 441
ILE A 442
THR A 445
 None
 0.95A 3bpxA-3w1hA:
undetectable
3bpxB-3w1hA:
undetectable		 3bpxA-3w1hA:
15.56
3bpxB-3w1hA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 1.01A 3d1zB-3w1hA:
undetectable		 3d1zB-3w1hA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.75A 3eeyC-3w1hA:
undetectable		 3eeyC-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.77A 3eeyD-3w1hA:
3.9		 3eeyD-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ASN A  81
ASP A 284
GLN A 291
 None
LLP  A 285 ( 4.3A)
None
 0.75A 3eeyE-3w1hA:
4.0		 3eeyE-3w1hA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.94A 3mwsA-3w1hA:
undetectable		 3mwsA-3w1hA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.97A 3nu5B-3w1hA:
undetectable		 3nu5B-3w1hA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.99A 3nu6B-3w1hA:
undetectable		 3nu6B-3w1hA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 0.92A 3sj1X-3w1hA:
undetectable		 3sj1X-3w1hA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.95A 3tkgB-3w1hA:
undetectable		 3tkgB-3w1hA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A 144
ALA A 143
GLY A 249
GLY A 281
ILE A 294
 None
LLP  A 285 ( 3.1A)
LLP  A 285 ( 3.0A)
None
None
 0.80A 3ufnA-3w1hA:
undetectable		 3ufnA-3w1hA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 288
THR A 327
ILE A  94
VAL A  93
 LLP  A 285 ( 3.8A)
None
None
None
 0.92A 3wriA-3w1hA:
undetectable		 3wriA-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 289
THR A 327
ILE A  94
VAL A  93
 None
 0.76A 3wriA-3w1hA:
undetectable		 3wriA-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 288
THR A 327
ILE A  94
VAL A  93
 LLP  A 285 ( 3.8A)
None
None
None
 0.91A 3wriB-3w1hA:
undetectable		 3wriB-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 289
THR A 327
ILE A  94
VAL A  93
 None
 0.77A 3wriB-3w1hA:
undetectable		 3wriB-3w1hA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ARG A  86
VAL A 167
GLU A 168
ASP A 247
VAL A 214
 LLP  A 285 ( 3.1A)
None
None
LLP  A 285 ( 3.3A)
LLP  A 285 ( 4.7A)
 1.28A 4danA-3w1hA:
undetectable
4danB-3w1hA:
undetectable		 4danA-3w1hA:
21.10
4danB-3w1hA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 0.95A 4hbfA-3w1hA:
undetectable		 4hbfA-3w1hA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 3.1A)
None
 1.01A 4hc3A-3w1hA:
undetectable		 4hc3A-3w1hA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 VAL A 214
ILE A 161
SER A 162
MET A 179
LEU A 186
 LLP  A 285 ( 4.7A)
None
None
None
None
 1.26A 4lhmA-3w1hA:
undetectable		 4lhmA-3w1hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 339
ALA A  87
ILE A  80
LEU A 256
ILE A 342
 None
LLP  A 285 ( 3.9A)
LLP  A 285 ( 4.8A)
None
None
 1.03A 4m2xE-3w1hA:
2.6		 4m2xE-3w1hA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 LEU A 130
ARG A 269
LEU A 253
LEU A 328
GLU A 124
 None
 1.18A 4wg0F-3w1hA:
undetectable
4wg0G-3w1hA:
undetectable
4wg0H-3w1hA:
undetectable		 4wg0F-3w1hA:
3.45
4wg0G-3w1hA:
3.45
4wg0H-3w1hA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 PHE A 147
ALA A 311
LEU A 314
GLY A 144
 None
 0.93A 4xk8a-3w1hA:
undetectable		 4xk8a-3w1hA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 328
GLU A 325
ILE A 123
LEU A 107
ILE A 316
 None
 1.22A 5j7wC-3w1hA:
undetectable		 5j7wC-3w1hA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 3w1h L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.93A 6difB-3w1hA:
undetectable		 6difB-3w1hA:
9.28