SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w1j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 421
ARG A 432
ARG A 423
 None
 1.08A 1l7fA-3w1jA:
undetectable		 1l7fA-3w1jA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 421
ARG A 432
ARG A 423
 None
 1.08A 1l7hA-3w1jA:
undetectable		 1l7hA-3w1jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 SER A 250
ILE A 302
VAL A 296
PHE A 268
ILE A 276
 None
 1.18A 1uduA-3w1jA:
undetectable		 1uduA-3w1jA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.95A 2pymB-3w1jA:
undetectable		 2pymB-3w1jA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.94A 2pynA-3w1jA:
undetectable		 2pynA-3w1jA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.95A 2pynB-3w1jA:
undetectable		 2pynB-3w1jA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.91A 2q63B-3w1jA:
undetectable		 2q63B-3w1jA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.91A 2qakB-3w1jA:
undetectable		 2qakB-3w1jA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 ALA A 414
THR A 441
ILE A 442
THR A 445
 None
 0.86A 3bpxA-3w1jA:
undetectable
3bpxB-3w1jA:
undetectable		 3bpxA-3w1jA:
16.15
3bpxB-3w1jA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.96A 3d1xB-3w1jA:
undetectable		 3d1xB-3w1jA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.97A 3d1zB-3w1jA:
undetectable		 3d1zB-3w1jA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 1.03A 3d20A-3w1jA:
undetectable		 3d20A-3w1jA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 VAL A 146
ALA A 154
ALA A 184
LEU A 210
ALA A 209
 None
 0.98A 3fc6C-3w1jA:
undetectable		 3fc6C-3w1jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 323
GLY A 283
GLY A 288
LEU A 253
ALA A 292
 None
LLP  A 285 ( 4.4A)
LLP  A 285 ( 3.4A)
None
None
 1.10A 3kkzB-3w1jA:
3.0		 3kkzB-3w1jA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.91A 3mwsA-3w1jA:
undetectable		 3mwsA-3w1jA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.93A 3ndtC-3w1jA:
undetectable		 3ndtC-3w1jA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.96A 3oxvA-3w1jA:
undetectable		 3oxvA-3w1jA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.98A 3oxvC-3w1jA:
undetectable		 3oxvC-3w1jA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.93A 3oxxA-3w1jA:
undetectable		 3oxxA-3w1jA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 1.00A 3pwrA-3w1jA:
undetectable		 3pwrA-3w1jA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 2.9A)
None
 1.02A 3sj1X-3w1jA:
undetectable		 3sj1X-3w1jA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.93A 3tkwA-3w1jA:
undetectable		 3tkwA-3w1jA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A 144
ALA A 143
GLY A 249
GLY A 281
ILE A 294
 None
LLP  A 285 ( 3.0A)
LLP  A 285 ( 2.9A)
None
None
 0.87A 3ufnA-3w1jA:
undetectable		 3ufnA-3w1jA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 GLY A 293
LEU A 127
LEU A 324
ASN A 140
ILE A 123
 None
None
None
K  A2001 (-4.2A)
None
 1.19A 3wdmC-3w1jA:
3.1		 3wdmC-3w1jA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 289
THR A 327
ILE A  94
VAL A  93
 None
 0.81A 3wriA-3w1jA:
undetectable		 3wriA-3w1jA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 5 GLY A 289
THR A 327
ILE A  94
VAL A  93
 None
 0.81A 3wriB-3w1jA:
undetectable		 3wriB-3w1jA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 123
LEU A 127
LYS A 286
GLY A 281
 None
None
LLP  A 285 ( 2.9A)
None
 1.05A 4hbfA-3w1jA:
undetectable		 4hbfA-3w1jA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 288
GLY A 289
GLY A 283
LEU A 286
VAL A  79
 LLP  A 285 ( 3.4A)
None
LLP  A 285 ( 4.4A)
LLP  A 285 ( 4.3A)
None
 1.01A 4htfB-3w1jA:
undetectable		 4htfB-3w1jA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 339
ALA A  87
ILE A  80
LEU A 256
ILE A 342
 None
LLP  A 285 ( 4.1A)
LLP  A 285 (-4.6A)
None
None
 0.99A 4km0B-3w1jA:
2.3		 4km0B-3w1jA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 11 VAL A 214
ILE A 161
SER A 162
MET A 179
LEU A 186
 None
 1.34A 4lhmA-3w1jA:
undetectable		 4lhmA-3w1jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 PHE A 147
ALA A 311
LEU A 314
GLY A 144
 None
 0.91A 4xk8a-3w1jA:
undetectable		 4xk8a-3w1jA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 6 ILE A 123
GLY A 117
ASN A 110
ILE A 120
 None
 0.90A 5j4nB-3w1jA:
undetectable		 5j4nB-3w1jA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 7 ASP A 277
GLY A 241
GLY A 237
HIS A 238
 None
 0.97A 5n9xA-3w1jA:
undetectable		 5n9xA-3w1jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 211
GLY A 202
ALA A 203
GLY A 190
ILE A 160
 None
 0.88A 5t2zA-3w1jA:
undetectable		 5t2zA-3w1jA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		4 / 8 LEU A 385
VAL A 341
LEU A 345
ILE A 342
 None
LLP  A 285 ( 4.9A)
None
None
 0.90A 6cb4A-3w1jA:
undetectable		 6cb4A-3w1jA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.50A 6dlzA-3w1jA:
3.0
6dlzD-3w1jA:
3.1		 6dlzA-3w1jA:
11.58
6dlzD-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.49A 6dlzB-3w1jA:
4.3
6dlzC-3w1jA:
3.1		 6dlzB-3w1jA:
11.58
6dlzC-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.48A 6dm0A-3w1jA:
3.1
6dm0D-3w1jA:
3.0		 6dm0A-3w1jA:
11.58
6dm0D-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.48A 6dm0B-3w1jA:
3.0
6dm0C-3w1jA:
2.9		 6dm0B-3w1jA:
11.58
6dm0C-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.49A 6dm1A-3w1jA:
3.0
6dm1D-3w1jA:
3.0		 6dm1A-3w1jA:
11.58
6dm1D-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.50A 6dm1B-3w1jA:
4.3
6dm1C-3w1jA:
3.1		 6dm1B-3w1jA:
11.58
6dm1C-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 PRO A 386
LEU A 286
SER A 250
ASP A 247
ILE A  80
 None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
LLP  A 285 (-4.6A)
 1.49A 6dm2A-3w1jA:
2.7
6dm2D-3w1jA:
3.2		 6dm2A-3w1jA:
11.58
6dm2D-3w1jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE
(Aquifex
aeolicus) 		5 / 9 ILE A  80
PRO A 386
LEU A 286
SER A 250
ASP A 247
 LLP  A 285 (-4.6A)
None
LLP  A 285 ( 4.3A)
None
LLP  A 285 ( 3.0A)
 1.49A 6dm2B-3w1jA:
2.4
6dm2C-3w1jA:
1.8		 6dm2B-3w1jA:
11.58
6dm2C-3w1jA:
11.58