SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3w1s AUTOPHAGY PROTEIN 5
UBIQUITIN-LIKE
PROTEIN ATG12
(Saccharomyces
cerevisiae) 		5 / 10 ALA C 155
PHE C 154
GLN A 147
GLY A 275
PHE A 276
 None
 1.17A 1uhoA-3w1sC:
undetectable		 1uhoA-3w1sC:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 6 TYR A  44
TRP A  83
TYR A  85
ILE A 131
 None
 1.39A 2xz5A-3w1sA:
undetectable
2xz5B-3w1sA:
undetectable		 2xz5A-3w1sA:
22.87
2xz5B-3w1sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3w1s UBIQUITIN-LIKE
PROTEIN ATG12
(Saccharomyces
cerevisiae) 		4 / 7 TYR C 149
VAL C 146
TYR C 147
ILE C 134
 None
 1.12A 2xz5B-3w1sC:
undetectable
2xz5E-3w1sC:
undetectable		 2xz5B-3w1sC:
15.60
2xz5E-3w1sC:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  37
LEU A  35
THR A  43
VAL A  87
LEU A  45
 None
 1.00A 3a51C-3w1sA:
undetectable		 3a51C-3w1sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3w1s UBIQUITIN-LIKE
PROTEIN ATG12
(Saccharomyces
cerevisiae) 		4 / 7 ILE C 106
ILE C 111
PHE C 136
LEU C 141
 None
 0.95A 3adxA-3w1sC:
undetectable		 3adxA-3w1sC:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 279
ASP A 274
ILE A 200
VAL A 151
GLN A 253
 None
 0.99A 3bwcB-3w1sA:
undetectable		 3bwcB-3w1sA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3w1s AUTOPHAGY PROTEIN 5
UBIQUITIN-LIKE
PROTEIN ATG12
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 200
GLN A 217
ILE A 232
LEU C 165
 None
 1.21A 3dzyD-3w1sA:
undetectable		 3dzyD-3w1sA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 8 TYR A  44
TRP A  83
TYR A  85
ILE A 131
 None
 1.31A 4bqtC-3w1sA:
undetectable
4bqtD-3w1sA:
undetectable		 4bqtC-3w1sA:
23.21
4bqtD-3w1sA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 SER A 159
MET A 163
ASP A 274
 None
 0.93A 4mm4B-3w1sA:
undetectable		 4mm4B-3w1sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  46
ALA A 134
PHE A  74
 None
 0.77A 4olbA-3w1sA:
undetectable		 4olbA-3w1sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 220
LEU A 277
LEU A 229
ILE A 236
 None
 0.79A 4rmjA-3w1sA:
undetectable		 4rmjA-3w1sA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  46
ALA A 134
PHE A  74
 None
 0.82A 4w5nA-3w1sA:
undetectable		 4w5nA-3w1sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  46
ALA A 134
PHE A  74
 None
 0.77A 4z4iA-3w1sA:
undetectable		 4z4iA-3w1sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  46
ALA A 134
PHE A  74
 None
 0.76A 5js1A-3w1sA:
undetectable		 5js1A-3w1sA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 263
THR A 228
ILE A 257
ILE A 279
ILE A 236
 None
 1.04A 6ebzA-3w1sA:
undetectable		 6ebzA-3w1sA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 263
THR A 228
ILE A 257
ILE A 279
ILE A 236
 None
 1.05A 6ebzB-3w1sA:
undetectable		 6ebzB-3w1sA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3w1s AUTOPHAGY PROTEIN 5
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 263
THR A 228
ILE A 257
ILE A 279
ILE A 236
 None
 1.08A 6ebzD-3w1sA:
undetectable		 6ebzD-3w1sA:
13.38