SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VOU_A_ACTA1397_0 (2,6-DIHYDROXYPYRIDIN E HYDROXYLASE)	3w1y	MICROTUBULE-ASSOCIAT ED PROTEIN 1A/1B, LIGHT CHAIN 3 (Trypanosoma brucei)	3 / 3	PRO A 32 GLY A 121 TYR A 113	None	0.74A	2vouA-3w1yA: undetectable	2vouA-3w1yA: 14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBG_A_ACTA207_0 (FAD-LINKED SULFHYDRYL OXIDASE ALR)	3w1y	MICROTUBULE-ASSOCIAT ED PROTEIN 1A/1B, LIGHT CHAIN 3 (Trypanosoma brucei)	4 / 7	LEU A 68 ARG A 24 THR A 20 ALA A 23	None	1.30A	3mbgA-3w1yA: undetectable 3mbgB-3w1yA: undetectable	3mbgA-3w1yA: 23.97 3mbgB-3w1yA: 23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACA_B_DXCB1473_0 (TRANSLATION ELONGATION FACTOR SELB)	3w1y	MICROTUBULE-ASSOCIAT ED PROTEIN 1A/1B, LIGHT CHAIN 3 (Trypanosoma brucei)	5 / 9	ASP A 111 ILE A 112 GLY A 110 VAL A 125 ARG A 85	None	1.37A	4acaB-3w1yA: undetectable 4acaC-3w1yA: undetectable	4acaB-3w1yA: 13.28 4acaC-3w1yA: 13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_2_BEZ2801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 BEZ-LEU-LEU)	3w1y	MICROTUBULE-ASSOCIAT ED PROTEIN 1A/1B, LIGHT CHAIN 3 (Trypanosoma brucei)	4 / 4	LEU A 102 ARG A 115 ILE A 98 ILE A 112	None	1.20A	5dzk2-3w1yA: undetectable 5dzkM-3w1yA: undetectable 5dzkN-3w1yA: undetectable	5dzk2-3w1yA: 2.78 5dzkM-3w1yA: 21.00 5dzkN-3w1yA: 21.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2VOU_A_ACTA1397_0","2,6-DIHYDROXYPYRIDINE HYDROXYLASE","3w1y","MICROTUBULE-ASSOCIATED PROTEIN 1A\/1B, LIGHT CHAIN 3","Trypanosoma brucei",3,"PRO A  32;GLY A 121;TYR A 113","None","0.74A","2vouA-3w1yA:undetectable","2vouA-3w1yA:14.95"],["3MBG_A_ACTA207_0","FAD-LINKED SULFHYDRYL OXIDASE ALR","3w1y","MICROTUBULE-ASSOCIATED PROTEIN 1A\/1B, LIGHT CHAIN 3","Trypanosoma brucei",4,"LEU A  68;ARG A  24;THR A  20;ALA A  23","None","1.30A","3mbgA-3w1yA:undetectable;3mbgB-3w1yA:undetectable","3mbgA-3w1yA:23.97;3mbgB-3w1yA:23.97"],["4ACA_B_DXCB1473_0","TRANSLATION ELONGATION FACTOR SELB","3w1y","MICROTUBULE-ASSOCIATED PROTEIN 1A\/1B, LIGHT CHAIN 3","Trypanosoma brucei",5,"ASP A 111;ILE A 112;GLY A 110;VAL A 125;ARG A  85","None","1.37A","4acaB-3w1yA:undetectable;4acaC-3w1yA:undetectable","4acaB-3w1yA:13.28;4acaC-3w1yA:13.28"],["5DZK_2_BEZ2801_0","ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1;BEZ-LEU-LEU","3w1y","MICROTUBULE-ASSOCIATED PROTEIN 1A\/1B, LIGHT CHAIN 3","Trypanosoma brucei",4,"LEU A 102;ARG A 115;ILE A  98;ILE A 112","None","1.20A","5dzk2-3w1yA:undetectable;5dzkM-3w1yA:undetectable;5dzkN-3w1yA:undetectable","5dzk2-3w1yA:2.78;5dzkM-3w1yA:21.00;5dzkN-3w1yA:21.00"]]