SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w21'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 PHE A 272
PHE A 261
GLN A  82
TYR A  96
 None
AKG  A 302 (-4.3A)
None
None
 1.42A 2aoxA-3w21A:
undetectable		 2aoxA-3w21A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 PHE A 272
PHE A 261
GLN A  82
TYR A  96
 None
AKG  A 302 (-4.3A)
None
None
 1.43A 2aoxB-3w21A:
undetectable		 2aoxB-3w21A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		3 / 3 LEU A 245
LEU A 230
MET A 229
 None
 0.85A 2itzA-3w21A:
undetectable		 2itzA-3w21A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 HIS A 155
GLU A 249
PHE A 181
PRO A 232
 ZN  A 301 ( 3.4A)
None
AKG  A 302 (-3.5A)
None
 1.37A 3ql6A-3w21A:
undetectable		 3ql6A-3w21A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		4 / 7 ASP A  45
PRO A 234
GLN A 233
ARG A 256
 None
 1.20A 3s3oA-3w21A:
undetectable		 3s3oA-3w21A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		5 / 9 ARG A  11
LEU A   9
ALA A  26
LEU A 237
ILE A  38
 None
 1.06A 3wsjA-3w21A:
undetectable		 3wsjA-3w21A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 MET A  40
LEU A 237
ARG A 141
ILE A  23
ILE A  27
 None
None
AKG  A 302 (-3.7A)
None
None
 1.14A 4j24A-3w21A:
undetectable		 4j24A-3w21A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 MET A  40
LEU A 237
LEU A 260
ILE A  23
ILE A  27
 None
 1.13A 4j24A-3w21A:
undetectable		 4j24A-3w21A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 MET A  40
LEU A 237
ARG A 141
ILE A  23
ILE A  27
 None
None
AKG  A 302 (-3.7A)
None
None
 1.16A 4j24B-3w21A:
undetectable		 4j24B-3w21A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		4 / 8 GLY A 179
ARG A 199
PHE A 272
ILE A 263
 AKG  A 302 ( 4.8A)
None
None
None
 0.97A 4j4vC-3w21A:
undetectable		 4j4vC-3w21A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 ALA A  24
ILE A  27
ILE A  42
LEU A 237
GLY A 180
 None
 0.85A 4r3aB-3w21A:
undetectable		 4r3aB-3w21A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 ILE A 127
LEU A 170
GLU A 134
PHE A 135
ASN A 104
 None
 1.24A 5il1A-3w21A:
undetectable		 5il1A-3w21A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		5 / 12 ILE A 127
LEU A 170
GLU A 134
PHE A 135
ASN A 104
 None
 1.26A 5k7uA-3w21A:
undetectable		 5k7uA-3w21A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		4 / 5 ARG A 256
MET A 258
THR A 257
LEU A 182
 None
None
AKG  A 302 (-3.1A)
None
 1.37A 5x19J-3w21A:
undetectable		 5x19J-3w21A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3w21 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Burkholderia
ambifaria) 		4 / 5 ARG A 256
MET A 258
THR A 257
LEU A 182
 None
None
AKG  A 302 (-3.1A)
None
 1.30A 5x1bJ-3w21A:
undetectable		 5x1bJ-3w21A:
11.83