SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w2x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 PHE A 128
TYR A  68
GLY A  70
ALA A  63
TYR A 124
 None
None
None
FMT  A 302 (-4.0A)
None
 1.42A 2cojA-3w2xA:
undetectable
2cojB-3w2xA:
undetectable		 2cojA-3w2xA:
22.28
2cojB-3w2xA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 SER A   8
THR A  61
GLN A  98
 None
 0.65A 2fk8A-3w2xA:
undetectable		 2fk8A-3w2xA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ARG A 194
ASN A 153
THR A 204
 None
 0.88A 2q63A-3w2xA:
undetectable		 2q63A-3w2xA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 PHE A 152
ASP A 191
ARG A 220
THR A 192
GLY A 150
 None
 1.38A 2v0mA-3w2xA:
undetectable		 2v0mA-3w2xA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 TYR A  56
LEU A  36
VAL A  53
PHE A  22
VAL A  17
 None
 1.47A 3jwqA-3w2xA:
undetectable		 3jwqA-3w2xA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 TYR A 189
CYH A 149
TYR A 108
PHE A 132
 None
 1.27A 3po7A-3w2xA:
undetectable		 3po7A-3w2xA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 PHE A 132
PHE A  86
PHE A 152
ILE A 110
PHE A 184
 None
 1.41A 3t3rC-3w2xA:
undetectable		 3t3rC-3w2xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 THR A  75
VAL A  77
LEU A 257
VAL A   3
PHE A 230
 None
 1.40A 3tbgA-3w2xA:
undetectable		 3tbgA-3w2xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 THR A  75
VAL A  77
LEU A 257
VAL A   3
PHE A 230
 None
 1.35A 3tbgC-3w2xA:
undetectable		 3tbgC-3w2xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 TYR A 111
ARG A  96
GLU A 177
ARG A 121
 None
 1.42A 4kr4C-3w2xA:
undetectable		 4kr4C-3w2xA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 GLY A 172
SER A 171
LEU A 174
LEU A 126
TYR A 129
 None
None
FMT  A 303 ( 4.1A)
None
None
 1.02A 5hwkA-3w2xA:
undetectable		 5hwkA-3w2xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 GLY A 172
SER A 171
LEU A 174
LEU A 126
TYR A 129
 None
None
FMT  A 303 ( 4.1A)
None
None
 1.02A 5hwkB-3w2xA:
undetectable		 5hwkB-3w2xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 11 TYR A 129
ASP A 160
PHE A 152
ALA A 155
THR A 154
 None
 1.01A 6d6tD-3w2xA:
undetectable
6d6tE-3w2xA:
undetectable		 6d6tD-3w2xA:
21.53
6d6tE-3w2xA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3w2x EXODEOXYRIBONUCLEASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 PHE A 128
VAL A  71
SER A  69
TYR A 111
 None
 1.14A 6huoC-3w2xA:
undetectable
6huoD-3w2xA:
undetectable		 6huoC-3w2xA:
15.81
6huoD-3w2xA:
15.48