SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w2z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 9 ILE A  36
PHE A  40
ILE A 180
ALA A 183
GLU A 184
 None
 1.34A 1mrgA-3w2zA:
undetectable		 1mrgA-3w2zA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ALA A  57
VAL A  74
TRP A  78
 None
 0.75A 1tkqB-3w2zA:
undetectable		 1tkqB-3w2zA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 170
GLU A 163
HIS A  20
 None
 0.91A 1xwfA-3w2zA:
undetectable		 1xwfA-3w2zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 170
GLU A 163
HIS A  20
 None
 0.91A 1xwfB-3w2zA:
undetectable		 1xwfB-3w2zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 170
GLU A 163
HIS A  20
 None
 0.89A 1xwfC-3w2zA:
undetectable		 1xwfC-3w2zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 THR A 170
GLU A 163
HIS A  20
 None
 0.88A 1xwfD-3w2zA:
undetectable		 1xwfD-3w2zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 7 VAL A  56
SER A  73
ARG A  48
LEU A  51
 None
 1.13A 2f78B-3w2zA:
undetectable		 2f78B-3w2zA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 9 PHE A 176
VAL A 140
GLY A 148
ARG A  60
GLY A 177
 None
 1.41A 3csjB-3w2zA:
undetectable		 3csjB-3w2zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 GLU A 144
ALA A 143
PHE A 141
 None
 0.67A 4v1fC-3w2zA:
undetectable		 4v1fC-3w2zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 9 ILE A  36
PHE A  40
ILE A 180
ALA A 183
GLU A 184
 None
 1.33A 4yp2B-3w2zA:
undetectable		 4yp2B-3w2zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 9 ILE A  36
PHE A  40
ILE A 180
ALA A 183
GLU A 184
 None
 1.32A 5cf9B-3w2zA:
undetectable		 5cf9B-3w2zA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  59
ILE A 137
GLY A 101
THR A  98
 CYC  A 201 (-4.0A)
CYC  A 201 (-4.7A)
None
None
 0.93A 5esjA-3w2zA:
undetectable		 5esjA-3w2zA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  59
ILE A 137
GLY A 101
THR A  98
 CYC  A 201 (-4.0A)
CYC  A 201 (-4.7A)
None
None
 0.88A 5hs1A-3w2zA:
undetectable		 5hs1A-3w2zA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		3 / 3 VAL A  23
ARG A 102
PRO A 139
 None
CYC  A 201 (-3.7A)
None
 0.86A 5koxA-3w2zA:
undetectable		 5koxA-3w2zA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
(Nostoc
sp.
PCC
7120) 		5 / 12 ILE A  47
VAL A  26
GLN A 171
ILE A 136
ALA A 152
 None
 1.14A 5n0sB-3w2zA:
undetectable		 5n0sB-3w2zA:
19.28