SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ALA A 186
VAL A  98
TRP A 146
 None
 0.90A 1av2A-3w36A:
undetectable
1av2B-3w36A:
undetectable		 1av2A-3w36A:
4.62
1av2B-3w36A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 TRP A 146
ALA A 186
VAL A  98
 None
 0.99A 1av2C-3w36A:
undetectable
1av2D-3w36A:
undetectable		 1av2C-3w36A:
4.62
1av2D-3w36A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 6 LEU A  80
ILE A  82
ASP A  87
PRO A  85
 None
 1.17A 1ditH-3w36A:
undetectable
1ditP-3w36A:
undetectable		 1ditH-3w36A:
17.10
1ditP-3w36A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 12 ALA A 318
VAL A 493
GLY A 491
ASP A 419
HIS A 420
 None
None
None
None
VO4  A 600 (-4.5A)
 1.08A 1kxhA-3w36A:
undetectable		 1kxhA-3w36A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.81A 1m8eB-3w36A:
undetectable		 1m8eB-3w36A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.67A 1nodB-3w36A:
undetectable		 1nodB-3w36A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 8 VAL A 116
TYR A 117
ASP A 196
LEU A 355
 None
 1.13A 1pk2A-3w36A:
undetectable		 1pk2A-3w36A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 ALA A 318
GLU A 322
LEU A 415
ILE A 303
LEU A 310
 None
 1.21A 1qkuA-3w36A:
1.7		 1qkuA-3w36A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 ALA A 318
GLU A 322
LEU A 415
ILE A 303
LEU A 310
 None
 1.21A 1qkuB-3w36A:
1.8		 1qkuB-3w36A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 ALA A 318
GLU A 322
LEU A 415
ILE A 303
LEU A 310
 None
 1.21A 1qkuC-3w36A:
1.8		 1qkuC-3w36A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.71A 1qomA-3w36A:
undetectable		 1qomA-3w36A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ALA A 214
VAL A 262
TRP A 369
 None
 0.93A 1tkqA-3w36A:
undetectable		 1tkqA-3w36A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ALA A 186
VAL A  98
TRP A 146
 None
 0.89A 1w5uA-3w36A:
undetectable
1w5uB-3w36A:
undetectable		 1w5uA-3w36A:
4.62
1w5uB-3w36A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 TRP A 146
ALA A 186
VAL A  98
 None
 0.96A 1w5uA-3w36A:
undetectable
1w5uB-3w36A:
undetectable		 1w5uA-3w36A:
4.62
1w5uB-3w36A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 8 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.26A 2bteA-3w36A:
undetectable		 2bteA-3w36A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 8 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.27A 2bteD-3w36A:
undetectable		 2bteD-3w36A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.28A 2bytA-3w36A:
undetectable		 2bytA-3w36A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.27A 2bytD-3w36A:
undetectable		 2bytD-3w36A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 THR A  79
ALA A  67
TYR A  63
LEU A 160
 None
 0.91A 2hzqA-3w36A:
undetectable		 2hzqA-3w36A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 TRP A 146
ALA A 186
VAL A  98
 None
 0.90A 2izqC-3w36A:
undetectable
2izqD-3w36A:
undetectable		 2izqC-3w36A:
4.62
2izqD-3w36A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.68A 2nodB-3w36A:
undetectable		 2nodB-3w36A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 ILE A 136
GLN A 142
LEU A 157
LEU A 164
 None
 0.89A 2qqcB-3w36A:
undetectable
2qqcC-3w36A:
undetectable		 2qqcB-3w36A:
11.63
2qqcC-3w36A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 LEU A 157
LEU A 164
ILE A 136
GLN A 142
 None
 0.88A 2qqcA-3w36A:
undetectable
2qqcF-3w36A:
undetectable		 2qqcA-3w36A:
8.27
2qqcF-3w36A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 LEU A 157
LEU A 164
ILE A 136
GLN A 142
 None
 0.86A 2qqcG-3w36A:
undetectable
2qqcJ-3w36A:
undetectable		 2qqcG-3w36A:
8.27
2qqcJ-3w36A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 LEU A 157
LEU A 164
ILE A 136
GLN A 142
 None
 0.88A 2qqcI-3w36A:
undetectable
2qqcL-3w36A:
undetectable		 2qqcI-3w36A:
8.27
2qqcL-3w36A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 8 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.30A 2v0gA-3w36A:
undetectable		 2v0gA-3w36A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A  89
ILE A 366
GLY A 197
GLN A 265
THR A 266
 None
 0.96A 2wd9C-3w36A:
undetectable		 2wd9C-3w36A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.78A 3e68A-3w36A:
undetectable		 3e68A-3w36A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.77A 3e6tB-3w36A:
undetectable		 3e6tB-3w36A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.75A 3e7iB-3w36A:
undetectable		 3e7iB-3w36A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 TRP A 146
ALA A 186
VAL A  98
 None
 0.99A 3l8lC-3w36A:
undetectable
3l8lD-3w36A:
undetectable		 3l8lC-3w36A:
4.62
3l8lD-3w36A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.81A 3nw2A-3w36A:
undetectable		 3nw2A-3w36A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ARG A 385
ILE A 406
TRP A 411
 None
 0.71A 3nw2B-3w36A:
undetectable		 3nw2B-3w36A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 5 ILE A 303
PRO A 380
SER A 487
GLY A 492
 None
 1.05A 3tkdB-3w36A:
undetectable		 3tkdB-3w36A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 5 ILE A 303
PRO A 380
SER A 487
GLY A 492
 None
 1.06A 3tkdA-3w36A:
undetectable		 3tkdA-3w36A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.18A 4aq7A-3w36A:
undetectable		 4aq7A-3w36A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 GLU A 446
ASP A 448
ASP A 479
 None
 0.79A 4gc9A-3w36A:
undetectable		 4gc9A-3w36A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 5 PHE A 442
TYR A 441
THR A 434
ILE A 335
 None
 1.03A 4jx1E-3w36A:
undetectable		 4jx1E-3w36A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 11 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.01A 4qvlK-3w36A:
undetectable
4qvlL-3w36A:
undetectable		 4qvlK-3w36A:
17.68
4qvlL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 11 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.00A 4qvlY-3w36A:
undetectable
4qvlZ-3w36A:
undetectable		 4qvlY-3w36A:
17.68
4qvlZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.00A 4qvmK-3w36A:
undetectable
4qvmL-3w36A:
undetectable		 4qvmK-3w36A:
17.68
4qvmL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 0.99A 4qvmY-3w36A:
undetectable
4qvmZ-3w36A:
undetectable		 4qvmY-3w36A:
17.68
4qvmZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.03A 4qvnK-3w36A:
undetectable
4qvnL-3w36A:
undetectable		 4qvnK-3w36A:
17.87
4qvnL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.02A 4qvnY-3w36A:
undetectable
4qvnZ-3w36A:
undetectable		 4qvnY-3w36A:
17.87
4qvnZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.03A 4qvpK-3w36A:
undetectable
4qvpL-3w36A:
undetectable		 4qvpK-3w36A:
17.68
4qvpL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.03A 4qvpY-3w36A:
undetectable
4qvpZ-3w36A:
undetectable		 4qvpY-3w36A:
17.68
4qvpZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.03A 4qvqK-3w36A:
undetectable
4qvqL-3w36A:
undetectable		 4qvqK-3w36A:
17.87
4qvqL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.03A 4qvqY-3w36A:
undetectable
4qvqZ-3w36A:
undetectable		 4qvqY-3w36A:
17.87
4qvqZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 11 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.00A 4qvwK-3w36A:
undetectable
4qvwL-3w36A:
undetectable		 4qvwK-3w36A:
17.68
4qvwL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 11 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 0.99A 4qvwY-3w36A:
undetectable
4qvwZ-3w36A:
undetectable		 4qvwY-3w36A:
17.68
4qvwZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.01A 4qvyK-3w36A:
undetectable
4qvyL-3w36A:
undetectable		 4qvyK-3w36A:
17.68
4qvyL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.00A 4qvyY-3w36A:
undetectable
4qvyZ-3w36A:
undetectable		 4qvyY-3w36A:
17.68
4qvyZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.05A 4qw1Y-3w36A:
undetectable
4qw1Z-3w36A:
undetectable		 4qw1Y-3w36A:
17.68
4qw1Z-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 0.98A 4qw3K-3w36A:
undetectable
4qw3L-3w36A:
undetectable		 4qw3K-3w36A:
17.68
4qw3L-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 10 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 0.97A 4qw3Y-3w36A:
undetectable
4qw3Z-3w36A:
undetectable		 4qw3Y-3w36A:
17.68
4qw3Z-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.01A 4qwuK-3w36A:
undetectable
4qwuL-3w36A:
undetectable		 4qwuK-3w36A:
17.68
4qwuL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 GLN A 518
HIS A 514
ARG A 440
 None
 1.11A 4qyqA-3w36A:
undetectable		 4qyqA-3w36A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 GLN A 518
HIS A 514
ARG A 440
 None
 1.07A 4qyqB-3w36A:
undetectable		 4qyqB-3w36A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 4 GLU A 322
GLY A 418
HIS A 494
ARG A 488
 None
VO4  A 600 ( 4.8A)
VO4  A 600 (-3.4A)
VO4  A 600 (-4.0A)
 1.19A 4r82A-3w36A:
undetectable
4r82B-3w36A:
undetectable		 4r82A-3w36A:
16.98
4r82B-3w36A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 4 THR A 481
GLY A 510
ASP A 511
SER A 435
 None
 1.16A 4rfqA-3w36A:
undetectable		 4rfqA-3w36A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 7 PRO A 231
SER A 288
ASP A 500
THR A 502
 None
 1.13A 4uacA-3w36A:
undetectable		 4uacA-3w36A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 11 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.00A 5bxnK-3w36A:
undetectable
5bxnL-3w36A:
undetectable		 5bxnK-3w36A:
17.68
5bxnL-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 11 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 1.01A 5bxnY-3w36A:
undetectable
5bxnZ-3w36A:
undetectable		 5bxnY-3w36A:
17.68
5bxnZ-3w36A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 266
GLN A 142
ASN A  95
LEU A  92
LEU A 365
 None
 1.36A 5fhzB-3w36A:
undetectable		 5fhzB-3w36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ALA A 306
ASN A 309
LEU A 310
 None
 0.36A 5i1oC-3w36A:
undetectable		 5i1oC-3w36A:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 ALA A 306
ASN A 309
LEU A 310
 None
 0.37A 5i1pD-3w36A:
undetectable		 5i1pD-3w36A:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		4 / 8 THR A 172
ARG A 123
PRO A 121
ILE A 181
 None
 1.14A 5jhdE-3w36A:
undetectable
5jhdG-3w36A:
undetectable		 5jhdE-3w36A:
17.60
5jhdG-3w36A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		3 / 3 LYS A  60
ASP A  61
ARG A 132
 None
 1.06A 5jwaA-3w36A:
undetectable
5jwaH-3w36A:
undetectable		 5jwaA-3w36A:
22.04
5jwaH-3w36A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 0.92A 5l5zK-3w36A:
undetectable
5l5zL-3w36A:
undetectable		 5l5zK-3w36A:
17.58
5l5zL-3w36A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 THR A 481
ALA A 433
THR A 434
ALA A 360
ASP A 511
 None
 0.92A 5l5zY-3w36A:
undetectable
5l5zZ-3w36A:
undetectable		 5l5zY-3w36A:
17.58
5l5zZ-3w36A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 12 VAL A  88
LEU A 365
SER A 435
ARG A 439
ILE A 328
 None
 1.19A 5vooA-3w36A:
undetectable		 5vooA-3w36A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 12 VAL A  88
LEU A 365
SER A 435
ARG A 439
ILE A 328
 None
 1.20A 5vooC-3w36A:
undetectable		 5vooC-3w36A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 LEU A 317
SER A 487
ILE A 474
PHE A 480
ILE A 320
 None
 1.25A 6ef6A-3w36A:
undetectable		 6ef6A-3w36A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3w36 NAPH1
(Streptomyces
sp.
CNQ525) 		5 / 9 LEU A 317
SER A 487
THR A 483
ILE A 474
ILE A 320
 None
 1.08A 6ef6A-3w36A:
undetectable		 6ef6A-3w36A:
20.65