SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w3s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 4 THR A 138
LEU A 137
VAL A 155
LEU A 158
 None
 0.93A 1fbmD-3w3sA:
undetectable		 1fbmD-3w3sA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 5 TYR A 323
GLU A 368
PHE A 409
ALA A 317
 None
SSA  A2002 ( 2.5A)
PT  A2004 (-0.7A)
SSA  A2002 (-4.4A)
 1.40A 1oniE-3w3sA:
0.0
1oniF-3w3sA:
0.0		 1oniE-3w3sA:
12.29
1oniF-3w3sA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 12 ALA A  76
ALA A  77
LEU A  38
VAL A  26
LEU A  11
 None
 1.05A 1xdkE-3w3sA:
undetectable		 1xdkE-3w3sA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 12 ILE A  65
VAL A   9
ILE A  61
VAL A  80
LEU A  99
 None
 1.17A 1z9hD-3w3sA:
undetectable		 1z9hD-3w3sA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.24A 1zzrA-3w3sA:
undetectable
1zzrB-3w3sA:
undetectable		 1zzrA-3w3sA:
23.27
1zzrB-3w3sA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 6 ASP A 328
PHE A 464
THR A 255
GLU A 324
 None
 1.37A 2dttB-3w3sA:
undetectable
2dttC-3w3sA:
undetectable		 2dttB-3w3sA:
12.38
2dttC-3w3sA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 5 LEU A  11
GLY A  95
ILE A  22
ILE A  61
 None
C  B  56 ( 3.2A)
None
None
 0.83A 2q9rA-3w3sA:
undetectable		 2q9rA-3w3sA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 12 LEU A   3
PHE A   5
LEU A 108
LEU A 158
VAL A 122
 None
 1.39A 2qd4B-3w3sA:
undetectable		 2qd4B-3w3sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 GLU A 440
GLN A 493
ARG A 191
 None
 0.85A 2w3bB-3w3sA:
undetectable		 2w3bB-3w3sA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.16A 3dqrA-3w3sA:
undetectable
3dqrB-3w3sA:
undetectable		 3dqrA-3w3sA:
23.19
3dqrB-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.22A 3jx2A-3w3sA:
undetectable
3jx2B-3w3sA:
undetectable		 3jx2A-3w3sA:
23.19
3jx2B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 VAL A 129
ARG A 103
VAL A 107
GLU A 131
 None
 1.26A 3jx3A-3w3sA:
undetectable
3jx3B-3w3sA:
undetectable		 3jx3A-3w3sA:
23.19
3jx3B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.24A 3jx3A-3w3sA:
undetectable
3jx3B-3w3sA:
undetectable		 3jx3A-3w3sA:
23.19
3jx3B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.22A 3jx4A-3w3sA:
undetectable
3jx4B-3w3sA:
undetectable		 3jx4A-3w3sA:
23.19
3jx4B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.20A 3jx5A-3w3sA:
undetectable
3jx5B-3w3sA:
undetectable		 3jx5A-3w3sA:
23.19
3jx5B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.25A 3jx6A-3w3sA:
undetectable
3jx6B-3w3sA:
undetectable		 3jx6A-3w3sA:
23.19
3jx6B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 SER A 449
GLY A 451
SER A 405
 SSA  A2002 (-3.1A)
SSA  A2002 (-3.4A)
None
 0.56A 3loqA-3w3sA:
undetectable		 3loqA-3w3sA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.21A 3nlpA-3w3sA:
undetectable
3nlpB-3w3sA:
undetectable		 3nlpA-3w3sA:
23.19
3nlpB-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 5 LEU A 398
ILE A 505
PRO A 504
PHE A 231
 None
 1.21A 3s3vA-3w3sA:
undetectable		 3s3vA-3w3sA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.24A 4cx3A-3w3sA:
undetectable
4cx3B-3w3sA:
undetectable		 4cx3A-3w3sA:
23.19
4cx3B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.23A 4cx4A-3w3sA:
undetectable
4cx4B-3w3sA:
undetectable		 4cx4A-3w3sA:
23.19
4cx4B-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 8 ARG A 349
ARG A 360
PHE A 364
GLY A 451
ARG A 485
 SSA  A2002 (-3.0A)
None
SSA  A2002 ( 3.5A)
SSA  A2002 (-3.4A)
SSA  A2002 ( 3.7A)
 1.14A 4k87A-3w3sA:
22.6		 4k87A-3w3sA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 4 ILE A 367
VAL A 450
VAL A 483
ARG A 229
 None
SSA  A2002 (-4.8A)
None
None
 0.96A 4m6tA-3w3sA:
undetectable		 4m6tA-3w3sA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 11 THR A  25
LEU A  88
LEU A  13
SER A  14
ARG A  15
 None
None
None
C  B  56 ( 3.5A)
None
 1.45A 4m7tA-3w3sA:
undetectable		 4m7tA-3w3sA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 9 GLY A 471
LEU A 474
PRO A 333
VAL A 331
VAL A 466
 None
 1.44A 4mjrA-3w3sA:
undetectable		 4mjrA-3w3sA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 VAL A 370
ALA A 479
PHE A 242
 None
 0.89A 4olbA-3w3sA:
undetectable		 4olbA-3w3sA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 12 PHE A 242
GLY A 451
ALA A 388
VAL A 402
VAL A 455
 None
SSA  A2002 (-3.4A)
None
None
None
 1.13A 4wnwB-3w3sA:
undetectable		 4wnwB-3w3sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 6 ARG A 109
ARG A 112
ASP A 111
VAL A 135
 None
SO4  A2020 (-3.3A)
SO4  A2020 (-4.0A)
None
 1.13A 4xqeA-3w3sA:
undetectable		 4xqeA-3w3sA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 6 ARG A 109
ARG A 112
ASP A 111
VAL A 135
 None
SO4  A2020 (-3.3A)
SO4  A2020 (-4.0A)
None
 1.15A 4xqeB-3w3sA:
undetectable		 4xqeB-3w3sA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 8 ARG A 109
ARG A 112
ASP A 111
VAL A 135
 None
SO4  A2020 (-3.3A)
SO4  A2020 (-4.0A)
None
 1.14A 4xqgA-3w3sA:
undetectable		 4xqgA-3w3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 8 ARG A 109
ARG A 112
ASP A 111
VAL A 135
 None
SO4  A2020 (-3.3A)
SO4  A2020 (-4.0A)
None
 1.14A 4xqgB-3w3sA:
undetectable		 4xqgB-3w3sA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 SER A 405
ARG A 485
SER A 449
GLU A 430
 None
SSA  A2002 ( 3.7A)
SSA  A2002 (-3.1A)
None
 1.41A 4xzkA-3w3sA:
undetectable		 4xzkA-3w3sA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 VAL A 370
ALA A 479
PHE A 242
 None
 0.88A 4z4iA-3w3sA:
2.7		 4z4iA-3w3sA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 ASN A 454
SER A 452
ARG A 366
 SSA  A2002 (-4.3A)
SSA  A2002 (-2.9A)
SSA  A2002 (-3.0A)
 0.77A 5b2qA-3w3sA:
undetectable		 5b2qA-3w3sA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 7 GLU A 131
VAL A 129
ARG A 103
VAL A 107
 None
 1.21A 5g0pA-3w3sA:
undetectable
5g0pB-3w3sA:
undetectable		 5g0pA-3w3sA:
23.19
5g0pB-3w3sA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 10 GLY A 301
SER A 302
LEU A 303
LEU A 289
GLU A 288
 None
 1.00A 5hwkA-3w3sA:
undetectable		 5hwkA-3w3sA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 10 GLY A 301
SER A 302
LEU A 303
LEU A 289
GLU A 288
 None
 1.00A 5hwkB-3w3sA:
undetectable		 5hwkB-3w3sA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 11 SER A  53
SER A   6
GLU A   8
GLU A  64
VAL A  80
 None
 1.42A 5iqdA-3w3sA:
0.0		 5iqdA-3w3sA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 12 SER A  53
SER A   6
GLU A   8
GLU A  64
VAL A  80
 None
 1.40A 5iqdC-3w3sA:
undetectable		 5iqdC-3w3sA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		3 / 3 VAL A 370
ALA A 479
PHE A 242
 None
 0.87A 5js1A-3w3sA:
1.2		 5js1A-3w3sA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		4 / 6 LEU A 435
VAL A 433
LEU A 398
VAL A 450
 None
None
None
SSA  A2002 (-4.8A)
 0.75A 5x7zA-3w3sA:
0.9		 5x7zA-3w3sA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 10 ARG A 349
GLU A 351
PHE A 364
GLY A 482
ARG A 485
 SSA  A2002 (-3.0A)
SSA  A2002 (-3.2A)
SSA  A2002 ( 3.5A)
SSA  A2002 (-2.8A)
SSA  A2002 ( 3.7A)
 0.84A 6bniA-3w3sA:
9.8		 6bniA-3w3sA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3w3s TYPE-2 SERINE--TRNA
LIGASE
(Methanopyrus
kandleri) 		5 / 10 ARG A 349
GLU A 351
PHE A 364
GLY A 482
ARG A 485
 SSA  A2002 (-3.0A)
SSA  A2002 (-3.2A)
SSA  A2002 ( 3.5A)
SSA  A2002 (-2.8A)
SSA  A2002 ( 3.7A)
 0.84A 6bniB-3w3sA:
10.6		 6bniB-3w3sA:
9.30