SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.80A 1kifA-3w4kA:
53.9
1kifA-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.33A 1kifA-3w4kA:
53.9
1kifA-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.80A 1kifB-3w4kA:
53.9
1kifB-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.32A 1kifB-3w4kA:
53.9
1kifB-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.80A 1kifC-3w4kA:
53.8
1kifC-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.33A 1kifC-3w4kA:
53.8
1kifC-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.80A 1kifD-3w4kA:
53.8
1kifD-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.33A 1kifD-3w4kA:
53.8
1kifD-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.80A 1kifE-3w4kA:
53.9
1kifE-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.33A 1kifE-3w4kA:
53.9
1kifE-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.80A 1kifF-3w4kA:
53.9
1kifF-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.32A 1kifF-3w4kA:
53.9
1kifF-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.79A 1kifG-3w4kA:
53.9
1kifG-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.32A 1kifG-3w4kA:
53.9
1kifG-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.80A 1kifH-3w4kA:
53.9
1kifH-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.32A 1kifH-3w4kA:
53.9
1kifH-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.83A 1ve9A-3w4kA:
53.0
1ve9A-3w4kA:
84.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.34A 1ve9A-3w4kA:
53.0
1ve9A-3w4kA:
84.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 12 THR A  44
GLY A 281
GLY A 198
ARG A 279
ILE A 259
FAD  A 401 (-4.0A)
FAD  A 401 (-4.3A)
None
None
None
1.18A 2b25B-3w4kA:
3.0
2b25B-3w4kA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 6 LEU A 215
TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-4.1A)
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.35A 2du8A-3w4kA:
55.2
2du8A-3w4kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 6 TYR A 224
TYR A 228
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.74A 2du8A-3w4kA:
55.2
2du8A-3w4kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 6 LEU A 215
TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-4.1A)
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.34A 2du8B-3w4kA:
55.5
2du8B-3w4kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 5 TYR A 224
TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.68A 2du8G-3w4kA:
55.1
2du8G-3w4kA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 228
ILE A 230
ARG A 283
GLY A 313
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
0.29A 2du8J-3w4kA:
54.9
2du8J-3w4kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 12 THR A  44
ILE A   6
GLY A   7
GLY A   9
ALA A  36
FAD  A 401 (-4.0A)
None
FAD  A 401 (-3.1A)
FAD  A 401 (-3.2A)
FAD  A 401 (-3.8A)
0.97A 2fk8A-3w4kA:
undetectable
2fk8A-3w4kA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
3 / 3 TYR A  95
GLY A 131
PHE A 133
None
0.60A 2m2pB-3w4kA:
undetectable
2m2pB-3w4kA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 12 HIS A 319
LEU A 324
LEU A  87
LEU A 148
TYR A 144
None
1.34A 2prgB-3w4kA:
undetectable
2prgB-3w4kA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
3 / 3 PRO A 284
LEU A 195
ARG A 290
FAD  A 401 ( 4.7A)
None
None
0.82A 3aqiB-3w4kA:
undetectable
3aqiB-3w4kA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
3 / 3 SER A  68
GLN A  69
PHE A  72
None
0.82A 3g4lC-3w4kA:
undetectable
3g4lC-3w4kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 9 TYR A 314
THR A 317
GLY A  50
ALA A  48
THR A  44
None
FAD  A 401 (-4.0A)
FAD  A 401 (-3.8A)
FAD  A 401 (-3.3A)
FAD  A 401 (-4.0A)
1.30A 3jusB-3w4kA:
undetectable
3jusB-3w4kA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 LYS A 337
VAL A 305
ILE A 333
ARG A 172
None
1.38A 3pyyB-3w4kA:
undetectable
3pyyB-3w4kA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA601_0
(LACCASE-1)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 HIS A 311
CYH A 322
ILE A 318
LEU A 291
None
1.38A 3qpkA-3w4kA:
undetectable
3qpkA-3w4kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 12 HIS A 319
LEU A 324
LEU A  87
LEU A 148
TYR A 144
None
1.23A 4emaA-3w4kA:
undetectable
4emaA-3w4kA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 8 PHE A 125
ARG A 265
LEU A 266
PHE A  90
None
0.95A 4rkuA-3w4kA:
undetectable
4rkuJ-3w4kA:
undetectable
4rkuA-3w4kA:
19.97
4rkuJ-3w4kA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 ILE A  32
VAL A   3
CYH A  18
HIS A  24
None
1.33A 4rzvA-3w4kA:
undetectable
4rzvA-3w4kA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 THR A 237
THR A  44
HIS A 311
LEU A 316
None
FAD  A 401 (-4.0A)
None
FAD  A 401 (-3.8A)
1.30A 5axaA-3w4kA:
4.3
5axaA-3w4kA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
5 / 12 LEU A 291
ALA A 327
ILE A 306
LYS A 328
ILE A  19
None
1.09A 5itzB-3w4kA:
3.6
5itzB-3w4kA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 8 LEU A 215
ILE A 230
ALA A  49
PRO A 105
3LD  A 402 (-4.1A)
None
FAD  A 401 ( 4.0A)
None
0.92A 5m0oC-3w4kA:
undetectable
5m0oC-3w4kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 8 LEU A 296
GLU A 169
LEU A 189
ILE A   6
None
None
FAD  A 401 ( 4.9A)
None
1.01A 5mzjA-3w4kA:
undetectable
5mzjA-3w4kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 8 VAL A 177
HIS A 307
ASN A 308
GLU A 325
None
1.31A 6gneB-3w4kA:
4.4
6gneB-3w4kA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 8 VAL A 177
TYR A  23
GLU A 325
CYH A 322
None
1.11A 6gneB-3w4kA:
4.4
6gneB-3w4kA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)
3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)
4 / 5 TYR A 128
ASN A  96
TYR A  95
PHE A 125
None
1.10A 6h3dA-3w4kA:
4.1
6h3dA-3w4kA:
22.32