SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w53'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		3 / 3 ARG A 340
GLY A 355
ASP A 302
 None
 0.41A 1kf6A-3w53A:
undetectable
1kf6B-3w53A:
undetectable		 1kf6A-3w53A:
22.22
1kf6B-3w53A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 ALA A 208
GLY A 206
GLU A 214
LEU A 215
GLU A 152
 None
 1.30A 1mj2A-3w53A:
undetectable
1mj2B-3w53A:
undetectable		 1mj2A-3w53A:
12.69
1mj2B-3w53A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 ALA A 208
GLY A 206
GLU A 214
LEU A 215
GLU A 152
 None
 1.25A 1mj2C-3w53A:
undetectable
1mj2D-3w53A:
undetectable		 1mj2C-3w53A:
12.69
1mj2D-3w53A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 ALA A 208
GLY A 206
GLU A 214
LEU A 215
GLU A 152
 None
 1.27A 1mjoC-3w53A:
undetectable
1mjoD-3w53A:
undetectable		 1mjoC-3w53A:
12.69
1mjoD-3w53A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 11 GLY A 206
GLU A 214
LEU A 215
GLU A 152
LEU A 148
 None
 1.39A 1mjqA-3w53A:
undetectable
1mjqB-3w53A:
undetectable		 1mjqA-3w53A:
12.69
1mjqB-3w53A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 10 GLY A 206
GLU A 214
LEU A 215
GLU A 152
LEU A 148
 None
 1.39A 1mjqG-3w53A:
undetectable
1mjqH-3w53A:
undetectable		 1mjqG-3w53A:
12.69
1mjqH-3w53A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 5 ALA A 380
ASP A 428
ASP A 446
ASP A 394
 None
 1.12A 2nyuB-3w53A:
undetectable		 2nyuB-3w53A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 11 ASN A 169
GLU A 170
TYR A 300
GLU A 377
TRP A 424
 None
TRS  A 501 (-2.7A)
TRS  A 501 (-3.8A)
TRS  A 501 (-3.0A)
TRS  A 501 ( 4.1A)
 0.89A 2v3dB-3w53A:
15.1		 2v3dB-3w53A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 6 SER A  84
TYR A 105
VAL A 154
TYR A 150
 None
 1.47A 2x45A-3w53A:
undetectable		 2x45A-3w53A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 11 VAL A 246
LEU A 249
ILE A 177
PRO A 328
SER A 326
 None
 1.09A 3bjwB-3w53A:
undetectable		 3bjwB-3w53A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 VAL A 246
LEU A 249
ILE A 177
PRO A 328
SER A 326
 None
 1.07A 3bjwF-3w53A:
undetectable		 3bjwF-3w53A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 11 VAL A 246
LEU A 249
ILE A 177
PRO A 328
SER A 326
 None
 1.05A 3bjwH-3w53A:
undetectable		 3bjwH-3w53A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 7 LYS A 455
LEU A 426
ASP A 428
SER A  19
 None
 1.24A 3dzgA-3w53A:
1.4		 3dzgA-3w53A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 LEU A  56
ALA A  23
GLY A  30
SER A  86
SER A  38
 None
 1.18A 3gyqA-3w53A:
undetectable
3gyqB-3w53A:
3.1		 3gyqA-3w53A:
21.54
3gyqB-3w53A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 8 LEU A 249
VAL A 198
LEU A 195
ALA A 180
 None
 0.91A 3uniB-3w53A:
undetectable		 3uniB-3w53A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 6 ASP A 110
SER A 106
ASP A 103
ARG A 107
 None
 1.26A 4eysA-3w53A:
2.6		 4eysA-3w53A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 GLY A 441
VAL A 408
TYR A 421
ASN A 378
HIS A 404
 None
 1.45A 4ffwA-3w53A:
undetectable		 4ffwA-3w53A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		3 / 3 ASP A 303
ARG A 344
THR A 227
 None
 0.83A 4i13A-3w53A:
undetectable		 4i13A-3w53A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		3 / 3 ASP A 127
TRP A 424
SER A  84
 None
TRS  A 501 ( 4.1A)
None
 0.91A 4lrhB-3w53A:
undetectable		 4lrhB-3w53A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		3 / 3 ASP A 127
TRP A 424
SER A  84
 None
TRS  A 501 ( 4.1A)
None
 1.00A 4lrhF-3w53A:
undetectable		 4lrhF-3w53A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		3 / 3 ASP A 303
ARG A 344
THR A 227
 None
 0.85A 4p3rA-3w53A:
undetectable		 4p3rA-3w53A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 ASP A 284
THR A 167
THR A 209
ALA A 208
ALA A 210
 None
 1.35A 4u15A-3w53A:
undetectable		 4u15A-3w53A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		3 / 3 ASN A 169
PHE A 422
TYR A  81
 None
 0.62A 4u15A-3w53A:
undetectable		 4u15A-3w53A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 4 LEU A 224
ILE A 222
PRO A 257
LEU A 259
 None
 1.09A 5eb3A-3w53A:
undetectable		 5eb3A-3w53A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 10 PRO A 257
PRO A 328
ALA A 180
VAL A 271
PRO A 264
 None
 1.23A 5m0oA-3w53A:
undetectable		 5m0oA-3w53A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 5 HIS A 125
HIS A 205
LEU A 255
VAL A 258
 None
 1.02A 6bc9A-3w53A:
undetectable		 6bc9A-3w53A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		5 / 12 LEU A 255
VAL A 330
ARG A 252
ASP A 266
ASP A 270
 None
 1.39A 6bxnA-3w53A:
undetectable		 6bxnA-3w53A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		3 / 3 TYR A  66
HIS A  62
PHE A 104
 None
 0.95A 6esmA-3w53A:
undetectable		 6esmA-3w53A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3w53 BETA-GLUCOSIDASE
(Micrococcus
antarcticus) 		4 / 8 TRP A 432
HIS A 125
HIS A 301
GLU A 377
 TRS  A 501 (-4.9A)
None
None
TRS  A 501 (-3.0A)
 1.18A 6mn4D-3w53A:
undetectable		 6mn4D-3w53A:
20.04