SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w5i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 12 LEU A   6
LEU A   7
GLY A   8
VAL A 110
MET A  21
 None
 1.35A 2q7lA-3w5iA:
undetectable		 2q7lA-3w5iA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		4 / 6 LEU A  55
ILE A  53
PRO A  80
VAL A 187
 None
 1.11A 2ygoA-3w5iA:
undetectable		 2ygoA-3w5iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 10 LEU A 154
VAL A 157
ILE A  43
LEU A  45
ILE A   4
 None
 1.09A 3jw3A-3w5iA:
2.1		 3jw3A-3w5iA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		3 / 3 TYR A 163
LEU A 102
LYS A 103
 None
 0.55A 3sueD-3w5iA:
undetectable		 3sueD-3w5iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 12 ALA A   5
ILE A   4
ASN A 114
LEU A  17
MET A  21
 None
 1.03A 4r38A-3w5iA:
undetectable		 4r38A-3w5iA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 12 ALA A   5
ILE A   4
ASN A 114
LEU A  17
MET A  21
 None
 1.03A 4r38C-3w5iA:
undetectable		 4r38C-3w5iA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 12 ALA A   5
ILE A   4
ASN A 114
LEU A  17
MET A  21
 None
 1.03A 4r38D-3w5iA:
undetectable		 4r38D-3w5iA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 12 ALA A   5
ILE A   4
ASN A 114
LEU A  17
MET A  21
 None
 1.06A 4r3aA-3w5iA:
undetectable		 4r3aA-3w5iA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 9 ALA A  83
LEU A  38
LEU A  75
ASN A  78
LEU A  55
 None
 1.45A 4x30A-3w5iA:
undetectable		 4x30A-3w5iA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		4 / 5 LEU A  84
ALA A   5
LEU A  82
VAL A  71
 None
 1.11A 5cr1A-3w5iA:
undetectable		 5cr1A-3w5iA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 9 ILE A  58
PRO A  10
VAL A  36
LEU A  38
LEU A  61
 None
 1.19A 5iepA-3w5iA:
undetectable		 5iepA-3w5iA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		4 / 6 THR A 158
ARG A 162
ASP A  48
GLY A  46
 None
 1.05A 5mraA-3w5iA:
undetectable
5mraB-3w5iA:
undetectable		 5mraA-3w5iA:
20.27
5mraB-3w5iA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		5 / 12 ILE A  92
VAL A  85
VAL A 111
SER A 128
THR A  12
 None
None
None
None
SO4  A 301 (-4.8A)
 1.05A 6b52A-3w5iA:
3.2		 6b52A-3w5iA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		4 / 5 ILE A 137
SER A 132
ALA A 156
LEU A  82
 None
 1.06A 6dwnA-3w5iA:
undetectable		 6dwnA-3w5iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3w5i FERROUS IRON
TRANSPORT PROTEIN B
(Gallionella
capsiferriforman
s) 		4 / 7 LEU A  98
LEU A  55
LEU A 105
MET A 107
 None
 0.73A 6g9bA-3w5iA:
undetectable
6g9bB-3w5iA:
undetectable		 6g9bA-3w5iA:
18.52
6g9bB-3w5iA:
15.84