SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 ALA A 401
SER A 363
TRP A 448
LEU A 399
 None
 0.99A 1gahA-3w5nA:
18.9		 1gahA-3w5nA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 4 VAL A 627
TRP A 640
TRP A 347
 None
RAM  A1202 (-3.7A)
None
 1.37A 1gmkC-3w5nA:
undetectable
1gmkD-3w5nA:
undetectable		 1gmkC-3w5nA:
2.27
1gmkD-3w5nA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 TRP A 142
VAL A 283
TRP A 236
 None
 1.20A 1gmkC-3w5nA:
undetectable
1gmkD-3w5nA:
undetectable		 1gmkC-3w5nA:
2.27
1gmkD-3w5nA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 GLN A 973
TYR A 871
ARG A 872
 None
 0.86A 1gtbA-3w5nA:
3.6		 1gtbA-3w5nA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 1gtnB-3w5nA:
2.0
1gtnC-3w5nA:
2.1		 1gtnB-3w5nA:
5.72
1gtnC-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 1gtnH-3w5nA:
2.0
1gtnI-3w5nA:
1.9		 1gtnH-3w5nA:
5.72
1gtnI-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 GLY A 569
HIS A 568
ALA A 545
THR A 539
ALA A 546
 None
 1.20A 1gtnO-3w5nA:
1.5
1gtnP-3w5nA:
2.1		 1gtnO-3w5nA:
5.72
1gtnP-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 9 GLY A 569
HIS A 568
ALA A 545
THR A 539
ALA A 546
 None
 1.21A 1gtnQ-3w5nA:
2.1
1gtnR-3w5nA:
1.7		 1gtnQ-3w5nA:
5.72
1gtnR-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 SER A 767
ASP A 680
PHE A 678
ASN A 690
 None
 1.11A 1lhvA-3w5nA:
undetectable		 1lhvA-3w5nA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 THR A 629
PHE A 647
MET A 655
LEU A 661
 None
 1.10A 1lhvA-3w5nA:
undetectable		 1lhvA-3w5nA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 5 TYR A 375
GLU A 330
TYR A 439
PRO A 563
 None
 1.47A 1mclA-3w5nA:
4.6
1mclB-3w5nA:
undetectable
1mclP-3w5nA:
undetectable		 1mclA-3w5nA:
13.08
1mclB-3w5nA:
13.08
1mclP-3w5nA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ASP A 697
ALA A 775
TYR A 785
PRO A 784
ALA A 783
 None
 1.46A 1mskA-3w5nA:
undetectable		 1mskA-3w5nA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 LEU A 706
GLU A 656
ALA A 709
ALA A 648
 None
 1.07A 1sn0B-3w5nA:
undetectable
1sn0D-3w5nA:
undetectable		 1sn0B-3w5nA:
8.78
1sn0D-3w5nA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 GLY A 696
ASP A 697
ASN A 690
 None
 0.65A 1vq1A-3w5nA:
undetectable		 1vq1A-3w5nA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 LEU A 625
PHE A 598
MET A 655
SER A 657
 None
RAM  A1204 (-3.6A)
None
None
 0.89A 1wrlA-3w5nA:
undetectable
1wrlB-3w5nA:
undetectable		 1wrlA-3w5nA:
7.09
1wrlB-3w5nA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 LEU A 625
PHE A 598
MET A 655
SER A 657
 None
RAM  A1204 (-3.6A)
None
None
 0.84A 1wrlB-3w5nA:
undetectable		 1wrlB-3w5nA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 5 LEU A 625
PHE A 598
MET A 655
SER A 657
 None
RAM  A1204 (-3.6A)
None
None
 1.07A 1wrlC-3w5nA:
undetectable		 1wrlC-3w5nA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 LEU A 625
PHE A 598
MET A 655
SER A 657
 None
RAM  A1204 (-3.6A)
None
None
 0.87A 1wrlE-3w5nA:
undetectable		 1wrlE-3w5nA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 5 SER A 767
LEU A 817
LEU A 823
LEU A 852
 None
 0.91A 1yajD-3w5nA:
undetectable		 1yajD-3w5nA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 625
HIS A 527
GLY A 569
ASP A 549
GLY A 436
 None
 0.98A 1zz1C-3w5nA:
undetectable		 1zz1C-3w5nA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 LEU A 542
ALA A 540
ARG A 543
ALA A 547
PHE A 914
 None
 1.23A 2ejtA-3w5nA:
undetectable		 2ejtA-3w5nA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 TYR A 393
GLY A 383
TYR A 350
ASP A 432
 RAM  A1206 (-3.8A)
None
None
None
 1.12A 2g72A-3w5nA:
undetectable		 2g72A-3w5nA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 TRP A 421
SER A 364
ALA A 371
LEU A 372
 None
 0.98A 2o01A-3w5nA:
undetectable		 2o01A-3w5nA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 967
THR A1005
VAL A1021
GLY A1022
ALA A 990
 None
 1.08A 2x2iA-3w5nA:
7.1		 2x2iA-3w5nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 VAL A 967
THR A1005
VAL A1021
GLY A1022
ALA A 990
 None
 1.11A 2x2iC-3w5nA:
3.0		 2x2iC-3w5nA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 4 VAL A 523
TYR A 551
VAL A 515
SER A 586
 None
 1.39A 2x45B-3w5nA:
undetectable		 2x45B-3w5nA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 LEU A 242
GLY A 247
LEU A 165
SER A 217
 None
 0.96A 3aiaA-3w5nA:
undetectable		 3aiaA-3w5nA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 ALA A 540
LEU A 542
ALA A 528
ASN A 506
 None
 0.76A 3b6hA-3w5nA:
undetectable		 3b6hA-3w5nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 ALA A 540
LEU A 542
ALA A 528
ASN A 506
 None
 0.77A 3b6hB-3w5nA:
undetectable		 3b6hB-3w5nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 4 VAL A 587
ARG A 571
ILE A 537
THR A 584
 None
MPD  A1207 ( 4.1A)
None
None
 1.39A 3cl9A-3w5nA:
undetectable		 3cl9A-3w5nA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 VAL A 869
HIS A 866
THR A 864
VAL A 837
 None
 1.11A 3fhxB-3w5nA:
undetectable		 3fhxB-3w5nA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 SER A 217
ASP A 164
ASP A 168
 None
 0.88A 3iv6A-3w5nA:
undetectable		 3iv6A-3w5nA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 SER A 217
ASP A 164
ASP A 168
 None
 0.90A 3iv6C-3w5nA:
undetectable		 3iv6C-3w5nA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 SER A  28
ASP A 712
TYR A  13
PRO A  25
 None
 1.29A 3jqaB-3w5nA:
undetectable		 3jqaB-3w5nA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 LEU A 661
TRP A 664
GLY A 639
 None
 0.68A 3l35A-3w5nA:
undetectable
3l35H-3w5nA:
undetectable		 3l35A-3w5nA:
4.35
3l35H-3w5nA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 LEU A 661
TRP A 664
GLY A 639
 None
 0.64A 3l35B-3w5nA:
undetectable
3l35K-3w5nA:
undetectable		 3l35B-3w5nA:
4.35
3l35K-3w5nA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 PHE A 660
HIS A 593
THR A 594
VAL A 480
 None
 1.30A 3lb3A-3w5nA:
undetectable		 3lb3A-3w5nA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 4 GLY A 555
GLU A 559
ASP A 440
ASP A 518
 None
 1.40A 3mb5A-3w5nA:
undetectable		 3mb5A-3w5nA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 5 TRP A 257
ILE A 141
TRP A 236
TRP A 278
 None
 1.34A 3w37A-3w5nA:
0.8		 3w37A-3w5nA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 11 GLY A 639
ASP A 349
TYR A 393
ARG A 351
TRP A 347
 None
None
RAM  A1206 (-3.8A)
RAM  A1206 (-3.0A)
None
 1.36A 3wqvA-3w5nA:
undetectable		 3wqvA-3w5nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 11 GLY A 639
ASP A 349
TYR A 393
ARG A 351
TRP A 347
 None
None
RAM  A1206 (-3.8A)
RAM  A1206 (-3.0A)
None
 1.39A 3wqwA-3w5nA:
undetectable		 3wqwA-3w5nA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 GLY A 111
ARG A 414
GLU A 406
ARG A 318
 None
 1.40A 4bqfA-3w5nA:
undetectable		 4bqfA-3w5nA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 11 VAL A  47
LEU A  27
VAL A  59
LEU A  80
THR A 110
 None
 1.30A 4k0sA-3w5nA:
undetectable		 4k0sA-3w5nA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 5 GLU A 145
ARG A 157
PRO A 153
SER A 151
 None
 1.44A 4k17B-3w5nA:
undetectable		 4k17B-3w5nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 PRO A 479
SER A 595
VAL A 338
GLY A 339
 None
 1.00A 4klrB-3w5nA:
undetectable		 4klrB-3w5nA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 ASP A 341
TRP A 107
SER A 595
 None
 0.90A 4lrhA-3w5nA:
undetectable		 4lrhA-3w5nA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 4 ALA A 768
ALA A 771
ALA A 772
ALA A 775
 None
None
MPD  A1209 (-2.9A)
None
 0.10A 4oadA-3w5nA:
undetectable		 4oadA-3w5nA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 4 ALA A 768
ALA A 771
ALA A 772
ALA A 775
 None
None
MPD  A1209 (-2.9A)
None
 0.08A 4oaeA-3w5nA:
undetectable		 4oaeA-3w5nA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 GLU A 437
ASP A 549
LEU A 433
GLY A 509
HIS A 568
 None
 1.44A 4pgfA-3w5nA:
undetectable		 4pgfA-3w5nA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ILE A 123
ALA A 120
TYR A 329
LEU A 399
LEU A 372
 None
 1.48A 4qztC-3w5nA:
2.6		 4qztC-3w5nA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 GLU A 101
SER A  89
ARG A  46
TRP A  29
 None
 1.15A 4uhxA-3w5nA:
undetectable		 4uhxA-3w5nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 GLU A 101
SER A  89
ARG A  46
TRP A  29
 None
 1.15A 4uhxA-3w5nA:
undetectable		 4uhxA-3w5nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.27A 4v2yA-3w5nA:
undetectable		 4v2yA-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.29A 4v2zA-3w5nA:
undetectable		 4v2zA-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.28A 4v30A-3w5nA:
undetectable		 4v30A-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 GLY A 699
VAL A 700
VAL A 723
SER A 767
LEU A 727
 None
 1.09A 4yb6A-3w5nA:
undetectable
4yb6E-3w5nA:
undetectable		 4yb6A-3w5nA:
14.30
4yb6E-3w5nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 GLY A 699
VAL A 700
VAL A 723
SER A 767
LEU A 727
 None
 1.10A 4yb6B-3w5nA:
undetectable
4yb6C-3w5nA:
undetectable		 4yb6B-3w5nA:
14.30
4yb6C-3w5nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 GLY A 699
VAL A 700
VAL A 723
SER A 767
LEU A 727
 None
 1.07A 4yb6C-3w5nA:
undetectable
4yb6F-3w5nA:
undetectable		 4yb6C-3w5nA:
14.30
4yb6F-3w5nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 SER A 767
LEU A 727
GLY A 699
VAL A 700
VAL A 723
 None
 1.08A 4yb6D-3w5nA:
undetectable
4yb6E-3w5nA:
undetectable		 4yb6D-3w5nA:
14.30
4yb6E-3w5nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 SER A 767
LEU A 727
GLY A 699
VAL A 700
VAL A 723
 None
 1.10A 4yb6B-3w5nA:
undetectable
4yb6F-3w5nA:
undetectable		 4yb6B-3w5nA:
14.30
4yb6F-3w5nA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 5 ARG A 320
GLY A  19
GLU A 109
SER A 595
 None
NA  A1212 ( 4.6A)
None
None
 1.09A 4z3oA-3w5nA:
undetectable
4z3oB-3w5nA:
2.3		 4z3oA-3w5nA:
21.00
4z3oB-3w5nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.28A 5amiA-3w5nA:
undetectable		 5amiA-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.23A 5amkA-3w5nA:
undetectable		 5amkA-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.26A 5amkB-3w5nA:
undetectable		 5amkB-3w5nA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 ALA A 344
ARG A 320
GLY A  19
GLU A 109
 None
None
NA  A1212 ( 4.6A)
None
 0.89A 5bs8A-3w5nA:
3.2
5bs8C-3w5nA:
undetectable
5bs8D-3w5nA:
undetectable		 5bs8A-3w5nA:
20.89
5bs8C-3w5nA:
20.89
5bs8D-3w5nA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 ALA A 344
ARG A 320
GLY A  19
GLU A 109
 None
None
NA  A1212 ( 4.6A)
None
 0.85A 5bs8A-3w5nA:
3.2
5bs8B-3w5nA:
undetectable
5bs8C-3w5nA:
undetectable		 5bs8A-3w5nA:
20.89
5bs8B-3w5nA:
13.54
5bs8C-3w5nA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 ALA A 344
ARG A 320
GLY A  19
GLU A 109
 None
None
NA  A1212 ( 4.6A)
None
 0.87A 5btdA-3w5nA:
undetectable
5btdB-3w5nA:
undetectable
5btdC-3w5nA:
undetectable		 5btdA-3w5nA:
20.89
5btdB-3w5nA:
13.54
5btdC-3w5nA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 ALA A 344
ARG A 320
GLY A  19
GLU A 109
 None
None
NA  A1212 ( 4.6A)
None
 0.92A 5btdA-3w5nA:
undetectable
5btdC-3w5nA:
undetectable
5btdD-3w5nA:
undetectable		 5btdA-3w5nA:
20.89
5btdC-3w5nA:
20.89
5btdD-3w5nA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 ALA A 344
ARG A 320
GLY A  19
GLU A 109
 None
None
NA  A1212 ( 4.6A)
None
 0.87A 5btgA-3w5nA:
undetectable
5btgB-3w5nA:
undetectable
5btgC-3w5nA:
undetectable		 5btgA-3w5nA:
20.89
5btgB-3w5nA:
13.54
5btgC-3w5nA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.16A 5eeuF-3w5nA:
2.0
5eeuG-3w5nA:
2.0		 5eeuF-3w5nA:
5.72
5eeuG-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.16A 5eeuI-3w5nA:
2.0
5eeuJ-3w5nA:
1.8		 5eeuI-3w5nA:
5.72
5eeuJ-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.16A 5eevF-3w5nA:
2.0
5eevG-3w5nA:
2.0		 5eevF-3w5nA:
5.72
5eevG-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.16A 5eevI-3w5nA:
2.0
5eevJ-3w5nA:
2.0		 5eevI-3w5nA:
5.72
5eevJ-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.16A 5eewF-3w5nA:
2.0
5eewG-3w5nA:
2.0		 5eewF-3w5nA:
5.72
5eewG-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.16A 5eewI-3w5nA:
1.8
5eewJ-3w5nA:
2.0		 5eewI-3w5nA:
5.72
5eewJ-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 5eexF-3w5nA:
2.0
5eexG-3w5nA:
1.8		 5eexF-3w5nA:
5.72
5eexG-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 5eeyF-3w5nA:
2.0
5eeyG-3w5nA:
2.0		 5eeyF-3w5nA:
5.72
5eeyG-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.16A 5eezF-3w5nA:
2.0
5eezG-3w5nA:
2.0		 5eezF-3w5nA:
5.72
5eezG-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 5ef0F-3w5nA:
2.0
5ef0G-3w5nA:
1.9		 5ef0F-3w5nA:
5.72
5ef0G-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 5ef1F-3w5nA:
1.8
5ef1G-3w5nA:
1.8		 5ef1F-3w5nA:
5.72
5ef1G-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 5ef2F-3w5nA:
2.0
5ef2G-3w5nA:
2.0		 5ef2F-3w5nA:
5.72
5ef2G-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 ALA A 546
GLY A 569
HIS A 568
ALA A 545
THR A 539
 None
 1.17A 5ef3F-3w5nA:
2.0
5ef3G-3w5nA:
2.0		 5ef3F-3w5nA:
5.72
5ef3G-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 TRP A 107
GLU A 109
ASP A 360
 None
 0.95A 5gqbA-3w5nA:
3.5		 5gqbA-3w5nA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 6 VAL A 215
HIS A 216
LEU A 165
LEU A 222
 None
 1.14A 5hrqB-3w5nA:
undetectable
5hrqI-3w5nA:
undetectable
5hrqJ-3w5nA:
undetectable		 5hrqB-3w5nA:
2.88
5hrqI-3w5nA:
1.87
5hrqJ-3w5nA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 VAL A 750
SER A 848
TRP A 897
 None
 1.00A 5jwaA-3w5nA:
undetectable		 5jwaA-3w5nA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 MET A 507
GLN A 505
ARG A 571
 None
None
MPD  A1207 ( 4.1A)
 1.05A 5m35B-3w5nA:
4.1		 5m35B-3w5nA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 MET A 507
GLN A 505
ARG A 571
 None
None
MPD  A1207 ( 4.1A)
 1.05A 5m36A-3w5nA:
6.3		 5m36A-3w5nA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 ALA A 682
ASP A 630
ASN A 687
PHE A 388
 None
RAM  A1202 (-3.4A)
RAM  A1206 (-3.1A)
None
 0.99A 5mvsB-3w5nA:
2.6		 5mvsB-3w5nA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 ASP A 630
ASP A 643
ARG A 896
HIS A 916
 RAM  A1202 (-3.4A)
RAM  A1202 (-2.8A)
None
RAM  A1202 (-4.0A)
 0.67A 5nekD-3w5nA:
undetectable		 5nekD-3w5nA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 LEU A 503
GLY A 504
VAL A 500
LEU A 501
ALA A 488
 None
 1.10A 5o96E-3w5nA:
undetectable
5o96F-3w5nA:
undetectable		 5o96E-3w5nA:
11.98
5o96F-3w5nA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 7 PRO A 628
TRP A 347
TRP A 380
TYR A 350
 None
 1.31A 5oh1A-3w5nA:
undetectable		 5oh1A-3w5nA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 ASN A 150
ASN A 228
ASP A 179
TRP A 292
 None
CA  A1201 (-3.2A)
RAM  A1203 ( 2.5A)
None
 1.29A 5vuoB-3w5nA:
undetectable		 5vuoB-3w5nA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 12 ALA A 693
GLY A 743
ASP A 697
ASP A 680
LEU A 668
 None
 1.16A 5wwsA-3w5nA:
undetectable		 5wwsA-3w5nA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 GLU A 636
HIS A 916
SER A 921
LEU A 847
 RAM  A1202 (-3.1A)
RAM  A1202 (-4.0A)
None
None
 1.07A 5y2tB-3w5nA:
undetectable		 5y2tB-3w5nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 TYR A 329
ALA A 374
LEU A 321
VAL A 338
GLY A 339
 None
 1.40A 5zbdA-3w5nA:
undetectable		 5zbdA-3w5nA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 TYR A 329
ALA A 374
LEU A 321
VAL A 338
GLY A 339
 None
 1.37A 5zbdB-3w5nA:
undetectable		 5zbdB-3w5nA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 ARG A 422
ARG A 306
ASP A 455
 None
 0.78A 6d8pA-3w5nA:
undetectable		 6d8pA-3w5nA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 11 TYR A 940
PHE A 600
ALA A 958
THR A 969
ALA A 990
 None
 1.43A 6efnA-3w5nA:
undetectable		 6efnA-3w5nA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 MET A 507
GLN A 505
ARG A 571
 None
None
MPD  A1207 ( 4.1A)
 1.05A 6fn9A-3w5nA:
6.0		 6fn9A-3w5nA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 MET A 507
GLN A 505
ARG A 571
 None
None
MPD  A1207 ( 4.1A)
 1.08A 6fnaB-3w5nA:
6.6		 6fnaB-3w5nA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		3 / 3 MET A 507
GLN A 505
ARG A 571
 None
None
MPD  A1207 ( 4.1A)
 1.05A 6fnbA-3w5nA:
6.8		 6fnbA-3w5nA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		4 / 8 VAL A 606
TRP A 882
HIS A 613
ASN A 615
 None
 1.12A 6gneB-3w5nA:
undetectable		 6gneB-3w5nA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 3w5n PUTATIVE
RHAMNOSIDASE
(Streptomyces
avermitilis) 		5 / 10 TYR A 572
ASP A 502
GLY A 504
ASP A 534
THR A 536
 MPD  A1207 (-4.6A)
None
None
None
None
 1.38A 6mn1B-3w5nA:
undetectable		 6mn1B-3w5nA:
5.85