SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 SER A  36
SER A  39
GLY A 149
GLY A  32
 GCP  A 801 (-4.0A)
MG  A 802 ( 2.0A)
GCP  A 801 (-3.6A)
None
 0.74A 1f5lA-3w6oA:
undetectable		 1f5lA-3w6oA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 197
ALA A 183
LEU A 182
THR A 288
ILE A 241
 None
 1.11A 1mx8A-3w6oA:
undetectable		 1mx8A-3w6oA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 SER A  36
SER A  39
GLY A 149
GLY A  32
 GCP  A 801 (-4.0A)
MG  A 802 ( 2.0A)
GCP  A 801 (-3.6A)
None
 0.79A 2vinA-3w6oA:
undetectable		 2vinA-3w6oA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 273
ASN A 280
GLY A 281
VAL A 245
 None
None
None
GCP  A 801 (-4.0A)
 0.93A 2y05A-3w6oA:
undetectable
2y05B-3w6oA:
undetectable		 2y05A-3w6oA:
22.82
2y05B-3w6oA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A  50
GLY A  -1
PRO A   0
MET A   1
 None
 1.11A 3hcrA-3w6oA:
2.2		 3hcrA-3w6oA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A  65
GLY A  -1
PRO A   0
MET A   1
 None
 0.59A 3hcrA-3w6oA:
2.2		 3hcrA-3w6oA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 243
GLY A 281
ALA A 187
LEU A 276
LEU A 217
 None
 1.14A 3p2kB-3w6oA:
undetectable		 3p2kB-3w6oA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 SER A  36
SER A  39
GLY A 149
GLY A  32
 GCP  A 801 (-4.0A)
MG  A 802 ( 2.0A)
GCP  A 801 (-3.6A)
None
 0.73A 3rxfA-3w6oA:
undetectable		 3rxfA-3w6oA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 242
VAL A  41
ILE A  28
LEU A 142
VAL A 140
 None
 1.11A 3w67C-3w6oA:
undetectable		 3w67C-3w6oA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 285
LEU A 289
VAL A  46
LEU A  67
LEU A  65
 None
 1.01A 4po0A-3w6oA:
2.8		 4po0A-3w6oA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 SER A  40
GLU A  89
LEU A  67
GLY A  -1
MET A   1
 GCP  A 801 (-2.6A)
None
None
None
None
 1.44A 4zjlA-3w6oA:
undetectable		 4zjlA-3w6oA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		6 / 11 ASN A 280
LEU A 230
LEU A 217
LEU A  45
LEU A 211
LEU A 289
 None
 1.46A 4zowA-3w6oA:
3.7		 4zowA-3w6oA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 5 GLU A 729
SER A 724
GLN A 721
ASP A  13
 None
 1.48A 5fhrB-3w6oA:
0.8		 5fhrB-3w6oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3w6o DYNAMIN-1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 166
GLY A 149
SER A 175
ILE A 174
PHE A 173
 None
GCP  A 801 (-3.6A)
None
None
None
 1.04A 5igwA-3w6oA:
undetectable		 5igwA-3w6oA:
21.22