SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  99
ASP A 102
LEU A 153
HIS A 144
 None
 1.28A 2qxsA-3w6xA:
undetectable		 2qxsA-3w6xA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  99
ASP A 102
LEU A 153
HIS A 144
 None
 1.29A 2qxsB-3w6xA:
undetectable		 2qxsB-3w6xA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  28
PHE A 120
PRO A  30
PHE A  33
 None
 1.25A 2ygnA-3w6xA:
undetectable		 2ygnA-3w6xA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 211
VAL A 196
GLY A 194
LEU A 173
ILE A 170
 None
None
None
HZP  A 301 (-4.9A)
None
 0.95A 2z0yB-3w6xA:
undetectable		 2z0yB-3w6xA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  61
VAL A  47
TYR A 121
PHE A 138
LEU A 139
 None
None
P6G  A 302 ( 4.6A)
None
None
 1.28A 3medA-3w6xA:
undetectable
3medB-3w6xA:
undetectable		 3medA-3w6xA:
18.16
3medB-3w6xA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 153
ALA A  44
MET A 228
ASN A 159
 None
 1.44A 3uq6A-3w6xA:
undetectable		 3uq6A-3w6xA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 117
GLY A 118
VAL A  98
ALA A  42
 None
 0.22A 4o0wA-3w6xA:
undetectable		 4o0wA-3w6xA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3w6x MPR1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 ILE A  69
LEU A  87
GLY A  85
PHE A  86
 None
 0.92A 5kmdC-3w6xA:
undetectable
5kmdD-3w6xA:
undetectable		 5kmdC-3w6xA:
23.63
5kmdD-3w6xA:
23.63