SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		5 / 12 LEU A 140
ASN A 142
LEU A 141
VAL A   7
LEU A 108
 None
 1.28A 2q7kA-3w77A:
undetectable		 2q7kA-3w77A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		5 / 12 PHE A 169
GLY A 171
LEU A 132
VAL A  93
PHE A  87
 None
 0.99A 2zulA-3w77A:
3.1		 2zulA-3w77A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		5 / 12 GLY A 145
ALA A  17
LEU A  22
LEU A 198
ILE A 193
 FMN  A 301 (-3.2A)
FMN  A 301 (-3.6A)
None
None
None
 1.02A 3adxB-3w77A:
undetectable		 3adxB-3w77A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		4 / 5 ILE A 193
HIS A 183
ARG A 144
GLY A 146
 None
FMN  A 301 (-4.1A)
None
FMN  A 301 (-3.6A)
 1.20A 3b9mA-3w77A:
undetectable		 3b9mA-3w77A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		3 / 3 GLY A 131
GLY A 168
GLY A 171
 None
 0.35A 3bogD-3w77A:
undetectable		 3bogD-3w77A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		5 / 12 PHE A 169
GLY A 171
LEU A 132
VAL A  93
PHE A  87
 None
 1.00A 3dmhA-3w77A:
3.2		 3dmhA-3w77A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		3 / 3 PHE A 186
VAL A 147
GLU A 150
 None
 0.76A 4fvqA-3w77A:
undetectable		 4fvqA-3w77A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		4 / 5 LYS A   8
LEU A  27
GLU A  24
TYR A  23
 None
 1.49A 4olaA-3w77A:
2.1		 4olaA-3w77A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		4 / 6 GLU A  41
TYR A  23
LEU A 141
PHE A   6
 None
 1.30A 4twdB-3w77A:
undetectable
4twdC-3w77A:
undetectable		 4twdB-3w77A:
21.31
4twdC-3w77A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		5 / 9 PHE A  26
GLU A 176
SER A 206
VAL A   4
VAL A  94
 None
 1.50A 4wnvB-3w77A:
undetectable		 4wnvB-3w77A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		5 / 11 GLY A 145
ALA A  17
LEU A  22
LEU A 198
ILE A 193
 FMN  A 301 (-3.2A)
FMN  A 301 (-3.6A)
None
None
None
 1.03A 4xumB-3w77A:
undetectable		 4xumB-3w77A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3w77 FMN-DEPENDENT
NADH-AZOREDUCTASE
(Bacillus
sp.
B29) 		3 / 3 LYS A   8
ASN A  10
SER A  19
 None
FMN  A 301 (-3.4A)
FMN  A 301 (-2.6A)
 1.22A 5yw0A-3w77A:
undetectable		 5yw0A-3w77A:
20.74