SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w7b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 160
LEU A 120
ALA A  92
ILE A 176
ILE A 156
 None
 1.10A 1crbA-3w7bA:
undetectable		 1crbA-3w7bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		5 / 7 ILE A  93
LEU A 105
ARG A  90
MET A 116
LEU A 270
 None
 1.39A 1v55A-3w7bA:
undetectable
1v55J-3w7bA:
undetectable		 1v55A-3w7bA:
18.86
1v55J-3w7bA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		5 / 9 GLY A 164
ILE A 156
VAL A 168
ILE A 189
VAL A 224
 None
 1.24A 2nnhB-3w7bA:
undetectable		 2nnhB-3w7bA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		5 / 11 LEU A 160
VAL A 165
GLY A 164
ILE A 156
GLU A 163
 None
 1.14A 2yy8A-3w7bA:
3.2
2yy8B-3w7bA:
2.7		 2yy8A-3w7bA:
23.02
2yy8B-3w7bA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		5 / 7 ILE A  93
LEU A 105
ARG A  90
MET A 116
LEU A 270
 None
 1.45A 3ag3A-3w7bA:
undetectable
3ag3J-3w7bA:
undetectable		 3ag3A-3w7bA:
18.86
3ag3J-3w7bA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		4 / 7 MET A  48
LEU A  34
SER A  38
GLY A  15
 None
 1.11A 3hcnA-3w7bA:
2.2		 3hcnA-3w7bA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		4 / 6 ILE A  93
LEU A 105
ARG A 119
MET A 116
 None
 0.96A 3wg7A-3w7bA:
undetectable
3wg7J-3w7bA:
undetectable		 3wg7A-3w7bA:
18.86
3wg7J-3w7bA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 264
ARG A 267
TRP A 268
 None
 1.04A 4b7nA-3w7bA:
undetectable		 4b7nA-3w7bA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 264
ARG A 267
TRP A 268
 None
 1.07A 4cpzC-3w7bA:
undetectable		 4cpzC-3w7bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 264
ARG A 267
TRP A 268
 None
 0.97A 4cpzE-3w7bA:
undetectable		 4cpzE-3w7bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 264
ARG A 267
TRP A 268
 None
 1.06A 4cpzF-3w7bA:
undetectable		 4cpzF-3w7bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 264
ARG A 267
TRP A 268
 None
 1.00A 4cpzG-3w7bA:
undetectable		 4cpzG-3w7bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 ARG A 264
ARG A 267
TRP A 268
 None
 1.07A 4cpzH-3w7bA:
undetectable		 4cpzH-3w7bA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 PRO A 179
VAL A 224
HIS A 222
 None
 0.80A 4pevC-3w7bA:
6.0		 4pevC-3w7bA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		5 / 12 LEU A 160
LEU A 120
ALA A  92
ILE A 176
ILE A 156
 None
 1.12A 5h8tA-3w7bA:
undetectable		 5h8tA-3w7bA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 VAL A 261
SER A 195
MET A 250
 None
 0.82A 5ikqA-3w7bA:
undetectable		 5ikqA-3w7bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		4 / 6 GLU A 258
LEU A 262
ARG A 259
ARG A 172
 None
 1.27A 5l6eA-3w7bA:
undetectable
5l6eB-3w7bA:
undetectable		 5l6eA-3w7bA:
21.52
5l6eB-3w7bA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		3 / 3 GLY A  15
VAL A   8
MET A  48
 None
 0.59A 5ycpA-3w7bA:
undetectable		 5ycpA-3w7bA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		4 / 8 GLY A 218
LEU A 253
GLY A 254
LEU A 257
 None
 0.70A 6mdqA-3w7bA:
undetectable		 6mdqA-3w7bA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Thermus
thermophilus) 		4 / 6 ILE A  93
LEU A 105
ARG A 119
MET A 116
 None
 1.03A 6nmfN-3w7bA:
undetectable
6nmfW-3w7bA:
undetectable		 6nmfN-3w7bA:
18.86
6nmfW-3w7bA:
9.82