SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		5 / 9 ALA A 248
VAL A 274
ILE A 251
VAL A 222
ILE A 221
 None
 0.99A 1hpvB-3w8gA:
undetectable		 1hpvB-3w8gA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		4 / 5 ALA A 216
ALA A 239
ALA A 248
VAL A 274
 None
 0.93A 2nyrB-3w8gA:
undetectable		 2nyrB-3w8gA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		5 / 9 ALA A 248
VAL A 274
ILE A 251
VAL A 222
ILE A 221
 None
 1.06A 2q5kA-3w8gA:
undetectable		 2q5kA-3w8gA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		5 / 11 ALA A 248
VAL A 274
ILE A 251
VAL A 222
ILE A 221
 None
 1.04A 2qhcA-3w8gA:
undetectable		 2qhcA-3w8gA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		5 / 10 ALA A 225
GLU A 226
LEU A 237
HIS A 285
LEU A 284
 None
 1.32A 3erdB-3w8gA:
undetectable		 3erdB-3w8gA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		5 / 10 ALA A 248
VAL A 274
ILE A 251
VAL A 222
ILE A 221
 None
 0.98A 3nujA-3w8gA:
undetectable		 3nujA-3w8gA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		4 / 5 ILE A 252
ALA A 225
HIS A 285
MET A 250
 None
 1.17A 4ac9B-3w8gA:
undetectable
4ac9C-3w8gA:
undetectable		 4ac9B-3w8gA:
14.91
4ac9C-3w8gA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		4 / 5 ILE A 252
ALA A 225
HIS A 285
MET A 250
 None
 1.17A 4acaB-3w8gA:
undetectable
4acaC-3w8gA:
undetectable		 4acaB-3w8gA:
14.91
4acaC-3w8gA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		5 / 10 ALA A 248
VAL A 274
ILE A 251
VAL A 222
ILE A 221
 None
 1.00A 4dqcA-3w8gA:
undetectable		 4dqcA-3w8gA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 3w8g MAGNETOSOME PROTEIN
MAMM
(Magnetospirillum
gryphiswaldense) 		5 / 10 ALA A 248
VAL A 274
ILE A 251
VAL A 222
ILE A 221
 None
 0.95A 6dj2A-3w8gA:
undetectable		 6dj2A-3w8gA:
21.43