SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DB1_A_VDXA428_2 (VITAMIN D NUCLEAR RECEPTOR)	3w8j	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	4 / 6	LEU A 89 ILE A 28 TRP A 65 TYR A 51	None	1.12A	1db1A-3w8jA: undetectable	1db1A-3w8jA: 17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NW3_A_SAMA500_0 (HISTONE METHYLTRANSFERASE DOT1L)	3w8j	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	5 / 12	GLY A 79 VAL A 39 ALA A 68 LEU A 20 PHE A 35	None None None K A 201 ( 4.5A) None	1.03A	1nw3A-3w8jA: undetectable	1nw3A-3w8jA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DMG_A_SAMA401_0 (PUTATIVE UNCHARACTERIZED PROTEIN TTHA1493)	3w8j	PROTEIN DISULFIDE-ISOMERASE A6 (Homo sapiens)	5 / 12	ARG A 60 TYR A 51 GLU A 29 ALA A 80 PRO A 53	None	1.46A	4dmgA-3w8jA: undetectable	4dmgA-3w8jA: 15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZW4_A_SAMA302_0 (PUTATIVE O-METHYLTRANSFERASE YRRM)	3w8j	PROTEIN DISULFIDE-ISOMERASE A6 C-TERMINAL PEPTIDE FROM PEROXIREDOXIN-4 (Homo sapiens; Mus musculus)	5 / 12	PRO A 32 GLY A 90 ALA C 4 ALA A 83 PHE A 98	None	1.04A	5zw4A-3w8jA: undetectable	5zw4A-3w8jA: 21.81

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DB1_A_VDXA428_2","VITAMIN D NUCLEAR RECEPTOR","3w8j","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",4,"LEU A  89;ILE A  28;TRP A  65;TYR A  51","None","1.12A","1db1A-3w8jA:undetectable","1db1A-3w8jA:17.31"],["1NW3_A_SAMA500_0","HISTONE METHYLTRANSFERASE DOT1L","3w8j","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",5,"GLY A  79;VAL A  39;ALA A  68;LEU A  20;PHE A  35","None;None;None;  K A 201 ( 4.5A);None","1.03A","1nw3A-3w8jA:undetectable","1nw3A-3w8jA:17.65"],["4DMG_A_SAMA401_0","PUTATIVE UNCHARACTERIZED PROTEIN TTHA1493","3w8j","PROTEIN DISULFIDE-ISOMERASE A6","Homo sapiens",5,"ARG A  60;TYR A  51;GLU A  29;ALA A  80;PRO A  53","None","1.46A","4dmgA-3w8jA:undetectable","4dmgA-3w8jA:15.17"],["5ZW4_A_SAMA302_0","PUTATIVE O-METHYLTRANSFERASE YRRM","3w8j","PROTEIN DISULFIDE-ISOMERASE A6;C-TERMINAL PEPTIDE FROM PEROXIREDOXIN-4","Homo sapiens;Mus musculus",5,"PRO A  32;GLY A  90;ALA C   4;ALA A  83;PHE A  98","None","1.04A","5zw4A-3w8jA:undetectable","5zw4A-3w8jA:21.81"]]