SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		4 / 7 ILE A 181
PHE A 132
PHE A  98
PHE A 125
 None
 1.14A 1e71M-3w8sA:
undetectable		 1e71M-3w8sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		4 / 7 ILE A 181
PHE A 132
PHE A  98
PHE A 125
 None
 1.13A 1e72M-3w8sA:
undetectable		 1e72M-3w8sA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 11 LYS A  73
ALA A  72
ALA A 156
LEU A 158
THR A  92
 None
 1.22A 1ictA-3w8sA:
undetectable
1ictC-3w8sA:
undetectable		 1ictA-3w8sA:
19.71
1ictC-3w8sA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 9 GLY A 150
LEU A 148
SER A 143
LEU A 140
ASP A 151
 None
 1.45A 2j2pB-3w8sA:
undetectable
2j2pC-3w8sA:
undetectable		 2j2pB-3w8sA:
24.05
2j2pC-3w8sA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		4 / 8 ILE A  99
PHE A 167
GLY A  13
MET A 110
 None
 0.80A 2qwxA-3w8sA:
undetectable
2qwxB-3w8sA:
undetectable		 2qwxA-3w8sA:
23.65
2qwxB-3w8sA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		4 / 8 ILE A  99
PHE A 167
GLY A  13
MET A 110
 None
 0.81A 2qx4A-3w8sA:
undetectable
2qx4B-3w8sA:
undetectable		 2qx4A-3w8sA:
22.92
2qx4B-3w8sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		3 / 3 ASP A 157
GLU A  84
SER A 190
 None
 0.81A 3p2kA-3w8sA:
undetectable		 3p2kA-3w8sA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 PRO A  52
LEU A   6
TYR A   8
PRO A 202
TYR A  29
 GSH  A 301 (-4.4A)
None
None
None
None
 1.42A 4ifyA-3w8sA:
undetectable		 4ifyA-3w8sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 PRO A  52
LEU A   6
TYR A   8
PRO A 202
TYR A  29
 GSH  A 301 (-4.4A)
None
None
None
None
 1.39A 4ig3A-3w8sA:
undetectable		 4ig3A-3w8sA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 ILE A  67
ALA A  62
LEU A  51
ILE A  32
ARG A  19
 None
None
GSH  A 301 (-4.5A)
None
None
 1.15A 4ptjA-3w8sA:
undetectable		 4ptjA-3w8sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		4 / 8 ILE A  99
PHE A 167
GLY A  13
MET A 110
 None
 0.77A 4qogA-3w8sA:
undetectable
4qogB-3w8sA:
undetectable		 4qogA-3w8sA:
23.65
4qogB-3w8sA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 11 HIS A 184
VAL A 188
LEU A 158
THR A 154
ALA A 156
 None
 1.37A 4ygfA-3w8sA:
undetectable		 4ygfA-3w8sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 11 HIS A 184
VAL A 188
LEU A 158
THR A 154
ALA A 156
 None
 1.42A 4ygfC-3w8sA:
undetectable		 4ygfC-3w8sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 HIS A 184
VAL A 188
LEU A 158
THR A 154
ALA A 156
 None
 1.36A 4yhaA-3w8sA:
undetectable		 4yhaA-3w8sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 HIS A 184
VAL A 188
LEU A 158
THR A 154
ALA A 156
 None
 1.35A 4yhaG-3w8sA:
undetectable		 4yhaG-3w8sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		4 / 6 ASN A 122
ASP A 116
THR A 171
PRO A 172
 None
 0.87A 4yoaA-3w8sA:
undetectable		 4yoaA-3w8sA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		4 / 6 ILE A  99
PHE A 132
PHE A 105
THR A 171
 None
 1.28A 5g08A-3w8sA:
undetectable		 5g08A-3w8sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 9 HIS A 184
VAL A 188
LEU A 158
THR A 154
ALA A 156
 None
 1.38A 5tt3G-3w8sA:
undetectable		 5tt3G-3w8sA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 12 ILE A  67
ALA A  62
LEU A  51
ILE A  32
ARG A  19
 None
None
GSH  A 301 (-4.5A)
None
None
 1.23A 5z6fA-3w8sA:
undetectable		 5z6fA-3w8sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		5 / 9 ILE A  67
ALA A  62
LEU A  51
ILE A  32
ARG A  19
 None
None
GSH  A 301 (-4.5A)
None
None
 1.29A 5z6lA-3w8sA:
undetectable		 5z6lA-3w8sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3w8s GLUTATHIONE
S-TRANSFERASE-3
(Necator
americanus) 		3 / 3 TRP A  39
GLU A  38
GLU A  45
 GSH  A 301 (-3.9A)
GOL  A 303 ( 4.7A)
None
 0.75A 6fhwA-3w8sA:
undetectable		 6fhwA-3w8sA:
15.24