SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 6 THR A 933
GLY A 910
THR A1011
ILE A 909
 None
 0.90A 1gtnD-3w9iA:
undetectable
1gtnE-3w9iA:
undetectable		 1gtnD-3w9iA:
5.72
1gtnE-3w9iA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 THR A 933
GLY A 910
THR A1011
ILE A 909
 None
 0.87A 1gtnF-3w9iA:
undetectable
1gtnG-3w9iA:
undetectable		 1gtnF-3w9iA:
5.72
1gtnG-3w9iA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 THR A 933
GLY A 910
THR A1011
ILE A 909
 None
 0.88A 1gtnJ-3w9iA:
undetectable
1gtnK-3w9iA:
undetectable		 1gtnJ-3w9iA:
5.72
1gtnK-3w9iA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 8 SER A  87
ASN A  83
GLN A  58
THR A  56
 None
 1.09A 1ig3A-3w9iA:
undetectable
1ig3B-3w9iA:
undetectable		 1ig3A-3w9iA:
12.82
1ig3B-3w9iA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 404
VAL A1005
GLY A 983
ALA A 347
LEU A 376
 None
None
None
None
LMT  A1101 ( 4.4A)
 1.03A 1r9oA-3w9iA:
undetectable		 1r9oA-3w9iA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ALA A1012
GLY A1008
ALA A1016
ILE A 934
SER A 937
 None
 0.96A 1ve3A-3w9iA:
undetectable		 1ve3A-3w9iA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 996
GLY A 992
GLU A 339
GLN A 998
PHE A 396
 None
 1.41A 2akeA-3w9iA:
undetectable		 2akeA-3w9iA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 912
PRO A 905
VAL A 908
ILE A 909
 None
 0.93A 2aoiB-3w9iA:
undetectable		 2aoiB-3w9iA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 THR A  56
SER A  53
GLY A  86
VAL A 749
ILE A 751
 None
 1.17A 2b25B-3w9iA:
undetectable		 2b25B-3w9iA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 11 GLU A 528
VAL A 531
ILE A 534
PHE A1018
HIS A 537
 None
 1.15A 2dg4A-3w9iA:
undetectable		 2dg4A-3w9iA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 675
LEU A 827
LEU A 674
PRO A 668
PHE A 573
 None
 1.00A 2f8lA-3w9iA:
2.8		 2f8lA-3w9iA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 497
VAL A 974
MET A 975
ILE A 410
 None
 1.08A 2hyyC-3w9iA:
undetectable		 2hyyC-3w9iA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 563
ALA A  37
VAL A 465
GLY A 464
GLN A 871
 None
 1.13A 2ve3B-3w9iA:
0.4		 2ve3B-3w9iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 THR A 915
GLY A1002
GLY A1007
LEU A 393
THR A 392
 None
 1.05A 2y7hC-3w9iA:
3.1		 2y7hC-3w9iA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
 None
 0.98A 2y7kC-3w9iA:
undetectable		 2y7kC-3w9iA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
 None
 0.98A 2y7kD-3w9iA:
undetectable		 2y7kD-3w9iA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 10 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
 None
 1.04A 2y7pA-3w9iA:
undetectable		 2y7pA-3w9iA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 THR A1011
ILE A 909
GLY A 907
GLY A1007
PHE A 926
 None
 0.99A 2y7wA-3w9iA:
undetectable		 2y7wA-3w9iA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 310
LEU A 137
ASN A 298
LEU A 166
ILE A 291
 None
 1.32A 3a50B-3w9iA:
undetectable		 3a50B-3w9iA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		6 / 12 MET A 626
PHE A 573
ARG A 716
ASN A 718
GLY A 719
LEU A 827
 None
 1.33A 3aodC-3w9iA:
51.6		 3aodC-3w9iA:
69.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 179
GLN A 176
ASP A 274
VAL A 159
 None
 0.75A 3fi0Q-3w9iA:
undetectable		 3fi0Q-3w9iA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 376
GLY A 403
ASP A 407
ASP A 408
THR A 379
 LMT  A1101 ( 4.4A)
None
None
None
None
 1.01A 3gguB-3w9iA:
undetectable		 3gguB-3w9iA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 631
VAL A 609
SER A 608
ALA A 574
ALA A 651
 None
 1.07A 3mdtA-3w9iA:
undetectable		 3mdtA-3w9iA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 861
GLY A 679
ASP A 681
LEU A 827
ALA A 665
 None
 1.30A 3ou6C-3w9iA:
undetectable		 3ou6C-3w9iA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 367
LEU A 497
ALA A 431
ALA A 430
 None
 0.85A 3r9tB-3w9iA:
undetectable		 3r9tB-3w9iA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 178
TYR A 327
LEU A 154
LYS A 151
 None
 1.40A 3sugA-3w9iA:
undetectable		 3sugA-3w9iA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 7 LEU A 674
THR A  93
LEU A 861
SER A 862
THR A 859
 None
 1.48A 4d7bA-3w9iA:
undetectable		 4d7bA-3w9iA:
7.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A  48
GLY A 179
SER A 180
ALA A 279
PHE A 615
 None
 1.01A 4dx5B-3w9iA:
52.1		 4dx5B-3w9iA:
69.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 576
ALA A 627
LEU A 598
VAL A 663
THR A 611
 None
 1.06A 4eckB-3w9iA:
undetectable		 4eckB-3w9iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 861
ALA A  42
SER A  79
LEU A 684
PHE A 683
 None
 1.40A 4iarA-3w9iA:
2.8		 4iarA-3w9iA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 172
ILE A 291
ILE A 306
PHE A 178
GLY A 141
 None
 0.99A 4kukA-3w9iA:
undetectable		 4kukA-3w9iA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 576
ALA A 627
SER A 593
VAL A 663
THR A 611
 None
 1.18A 4kyaC-3w9iA:
undetectable		 4kyaC-3w9iA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 651
VAL A 606
ALA A 627
ALA A 574
ILE A 629
 None
 1.11A 4lbgB-3w9iA:
undetectable		 4lbgB-3w9iA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 376
GLY A 403
ASP A 407
ASP A 408
THR A 379
 LMT  A1101 ( 4.4A)
None
None
None
None
 1.06A 4njtD-3w9iA:
undetectable		 4njtD-3w9iA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 376
PHE A 380
ILE A 402
GLY A 397
VAL A 340
 LMT  A1101 ( 4.4A)
LMT  A1101 ( 4.5A)
None
None
None
 1.07A 4nkvA-3w9iA:
undetectable		 4nkvA-3w9iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 376
PHE A 380
ILE A 402
GLY A 397
VAL A 340
 LMT  A1101 ( 4.4A)
LMT  A1101 ( 4.5A)
None
None
None
 1.04A 4nkvC-3w9iA:
undetectable		 4nkvC-3w9iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 376
PHE A 380
ILE A 402
GLY A 397
VAL A 340
 LMT  A1101 ( 4.4A)
LMT  A1101 ( 4.5A)
None
None
None
 1.05A 4nkvD-3w9iA:
2.3		 4nkvD-3w9iA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 565
LEU A 564
GLN A  34
 None
 0.59A 4pevB-3w9iA:
undetectable		 4pevB-3w9iA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 934
PRO A 905
TYR A 876
PHE A 556
 None
 0.81A 4qopC-3w9iA:
undetectable		 4qopC-3w9iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 8 PHE A 925
LEU A 393
LEU A 564
PHE A 563
 None
 0.70A 4qopC-3w9iA:
undetectable		 4qopC-3w9iA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 4 ASN A  83
VAL A  57
THR A  89
ILE A  90
 None
 1.45A 4retA-3w9iA:
2.4		 4retA-3w9iA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 4 ASN A  83
VAL A  57
THR A  89
ILE A  90
 None
 1.45A 4retC-3w9iA:
undetectable		 4retC-3w9iA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 THR A 343
GLY A 345
ALA A 347
ILE A 402
 None
 0.95A 4txnA-3w9iA:
undetectable		 4txnA-3w9iA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 THR A 343
GLY A 345
ALA A 347
ILE A 402
 None
 0.93A 4txnB-3w9iA:
undetectable		 4txnB-3w9iA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 THR A 343
GLY A 345
ALA A 347
ILE A 402
 None
 0.92A 4txnC-3w9iA:
undetectable		 4txnC-3w9iA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 THR A 343
GLY A 345
ALA A 347
ILE A 402
 None
 0.93A 4txnD-3w9iA:
undetectable		 4txnD-3w9iA:
14.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 179
SER A 180
ALA A 279
PHE A 610
ARG A 620
 None
 1.09A 4u8vB-3w9iA:
37.8		 4u8vB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 179
SER A 180
ALA A 279
PHE A 610
PHE A 615
 None
 0.82A 4u8vB-3w9iA:
37.8		 4u8vB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 277
ALA A 279
PHE A 610
VAL A 612
ARG A 620
 None
 0.95A 4u8vB-3w9iA:
37.8		 4u8vB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 277
ALA A 279
PHE A 610
VAL A 612
PHE A 615
 None
 0.75A 4u8vB-3w9iA:
37.8		 4u8vB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 179
SER A 180
ALA A 279
PHE A 610
ARG A 620
 None
 0.99A 4u8yB-3w9iA:
51.8		 4u8yB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 179
SER A 180
ALA A 279
PHE A 610
PHE A 615
 None
 0.81A 4u8yB-3w9iA:
51.8		 4u8yB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 277
ALA A 279
PHE A 610
VAL A 612
ARG A 620
 None
 0.91A 4u8yB-3w9iA:
51.8		 4u8yB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 277
ALA A 279
PHE A 610
VAL A 612
PHE A 615
 None
 0.77A 4u8yB-3w9iA:
51.8		 4u8yB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A 180
ALA A 279
PHE A 610
VAL A 612
ARG A 620
 None
 1.03A 4u8yB-3w9iA:
51.8		 4u8yB-3w9iA:
69.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A 180
ALA A 279
PHE A 610
VAL A 612
PHE A 615
 None
 0.77A 4u8yB-3w9iA:
51.8		 4u8yB-3w9iA:
69.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 291
LEU A 293
ALA A 303
ILE A 306
 None
 0.79A 4y03A-3w9iA:
2.3		 4y03A-3w9iA:
7.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A  79
MET A 626
LEU A 827
THR A 859
GLY A 860
 None
 1.05A 4zjlA-3w9iA:
52.1		 4zjlA-3w9iA:
69.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A  79
ASP A 681
GLU A 816
LEU A 827
THR A 859
 None
 0.85A 4zjoA-3w9iA:
52.6		 4zjoA-3w9iA:
69.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A  79
ASP A 681
GLU A 825
LEU A 827
THR A 859
 None
 0.75A 4zjoA-3w9iA:
52.6		 4zjoA-3w9iA:
69.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		7 / 11 TYR A  77
SER A  79
THR A  91
ASP A 681
GLU A 825
THR A 859
GLY A 860
 None
 0.66A 4zjoD-3w9iA:
51.9		 4zjoD-3w9iA:
69.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		7 / 11 TYR A  77
SER A  79
THR A  91
GLU A 673
ASP A 681
THR A 859
GLY A 860
 None
 1.21A 4zjoD-3w9iA:
51.9		 4zjoD-3w9iA:
69.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		7 / 11 TYR A  77
SER A  79
THR A  91
LYS A 292
GLU A 825
THR A 859
GLY A 860
 None
 0.80A 4zjoD-3w9iA:
51.9		 4zjoD-3w9iA:
69.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		6 / 11 SER A  79
LYS A 292
ASP A 681
ASN A 718
GLU A 825
GLY A 860
 None
 0.82A 4zjqA-3w9iA:
51.6		 4zjqA-3w9iA:
69.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A  79
THR A  91
LYS A 292
ASP A 681
GLU A 816
 None
 1.03A 4zjqD-3w9iA:
51.4		 4zjqD-3w9iA:
69.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 SER A  79
THR A  91
LYS A 292
ASP A 681
GLU A 825
 None
 0.88A 4zjqD-3w9iA:
51.4		 4zjqD-3w9iA:
69.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 MET A1009
THR A1013
LEU A1015
ALA A1016
GLY A 935
 None
 1.17A 5gs4A-3w9iA:
3.0		 5gs4A-3w9iA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 528
VAL A 531
ILE A 534
PHE A1018
HIS A 537
 None
 1.15A 5hkgA-3w9iA:
undetectable		 5hkgA-3w9iA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1001
ALA A1000
GLY A 983
GLY A 397
VAL A 399
 None
 1.06A 5i71A-3w9iA:
undetectable		 5i71A-3w9iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1001
ALA A1000
GLY A 983
GLY A 397
VAL A 399
 None
 1.09A 5i75A-3w9iA:
1.8		 5i75A-3w9iA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 5 ILE A  27
ILE A 337
HIS A 338
VAL A 341
 LMT  A1101 (-4.0A)
None
None
LMT  A1101 (-4.9A)
 0.83A 5jmnA-3w9iA:
54.6		 5jmnA-3w9iA:
69.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 TRP A1019
ILE A 544
SER A 977
ILE A 944
ALA A1012
 None
 1.21A 5oy02-3w9iA:
3.6		 5oy02-3w9iA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  45
VAL A 129
GLN A 112
 None
 0.59A 5qhaA-3w9iA:
undetectable		 5qhaA-3w9iA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 971
ARG A 967
ARG A 418
 None
 0.80A 5vcgA-3w9iA:
undetectable		 5vcgA-3w9iA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 327
ILE A 629
ASN A 676
LEU A 672
SER A 605
 None
 1.15A 6baaE-3w9iA:
0.0		 6baaE-3w9iA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 327
ILE A 629
ASN A 676
LEU A 672
SER A 605
 None
 1.15A 6baaF-3w9iA:
0.0		 6baaF-3w9iA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 327
ILE A 629
ASN A 676
LEU A 672
SER A 605
 None
 1.15A 6baaG-3w9iA:
0.8		 6baaG-3w9iA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_1
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 327
ILE A 629
ASN A 676
LEU A 672
SER A 605
 None
 1.15A 6baaH-3w9iA:
0.9		 6baaH-3w9iA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 485
ASP A 408
VAL A 411
GLY A 440
VAL A 416
 None
 0.89A 6dj1A-3w9iA:
undetectable		 6dj1A-3w9iA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		5 / 11 VAL A1027
SER A1028
THR A1029
LEU A 902
VAL A 945
 None
 1.22A 6dryA-3w9iA:
undetectable		 6dryA-3w9iA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  85
GLY A 625
GLY A 614
VAL A 612
 None
 0.92A 6ekzA-3w9iA:
undetectable		 6ekzA-3w9iA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 666
ARG A 716
GLN A 575
 None
 1.05A 6g1pB-3w9iA:
undetectable		 6g1pB-3w9iA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 185
GLY A 774
LEU A 188
ALA A 266
 None
 0.76A 6mdqA-3w9iA:
2.8		 6mdqA-3w9iA:
5.76