SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3w9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 8 SER A 109
VAL A 235
TYR A  24
VAL A 258
 None
 0.95A 1fduB-3w9uA:
undetectable		 1fduB-3w9uA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 12 TYR A 275
GLY A 266
ASN A 259
ILE A  28
LEU A  32
 None
 1.13A 1r30A-3w9uA:
undetectable		 1r30A-3w9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 12 TYR A 275
GLY A 266
ASN A 259
ILE A  28
LEU A  32
 None
 1.13A 1r30B-3w9uA:
undetectable		 1r30B-3w9uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 11 ARG A  86
ILE A  76
HIS A  78
GLY A  54
PHE A  75
 None
 1.23A 2azyA-3w9uA:
undetectable		 2azyA-3w9uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 12 LEU A 157
ALA A 135
ILE A 139
PHE A 226
ILE A 200
 None
 0.93A 2h42C-3w9uA:
undetectable		 2h42C-3w9uA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 8 THR A 100
TYR A 194
ILE A 246
SER A  98
 None
 1.03A 2xytE-3w9uA:
undetectable		 2xytE-3w9uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 8 THR A 100
TYR A 194
ILE A 246
SER A  98
 None
 0.98A 2xytH-3w9uA:
undetectable		 2xytH-3w9uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 7 THR A 100
TYR A 194
ILE A 246
SER A  98
 None
 0.98A 2xytI-3w9uA:
undetectable		 2xytI-3w9uA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 5 THR A 100
THR A   3
HIS A  37
LEU A  32
 None
 1.29A 3ce6A-3w9uA:
undetectable		 3ce6A-3w9uA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 5 THR A 100
THR A   3
HIS A  37
LEU A  32
 None
 1.28A 3ce6C-3w9uA:
2.6		 3ce6C-3w9uA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 6 THR A 100
TYR A 194
ILE A 246
SER A  98
 None
 1.19A 3peoG-3w9uA:
undetectable		 3peoG-3w9uA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 6 ILE A 154
GLU A 158
PHE A  47
ALA A 156
 None
 1.10A 3pgyA-3w9uA:
2.1
3pgyB-3w9uA:
undetectable		 3pgyA-3w9uA:
23.89
3pgyB-3w9uA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 12 ASP A 213
ALA A 262
PHE A  22
ASP A 253
HIS A  78
 None
 1.16A 3wemA-3w9uA:
undetectable		 3wemA-3w9uA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 12 GLY A 137
SER A  79
VAL A 105
VAL A 235
HIS A 254
 None
 0.99A 4ffwA-3w9uA:
6.2		 4ffwA-3w9uA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 11 LEU A 157
SER A 109
VAL A 132
LEU A 222
LEU A 234
 None
 1.29A 4or0B-3w9uA:
undetectable		 4or0B-3w9uA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 7 PHE A  60
LEU A  57
VAL A   8
PHE A  25
 None
 0.98A 4wnvD-3w9uA:
undetectable		 4wnvD-3w9uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 12 ASN A 210
HIS A 216
ASP A 253
PHE A 143
ILE A 255
 None
 1.49A 5dv4A-3w9uA:
undetectable		 5dv4A-3w9uA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 9 LEU A 234
SER A 159
ASN A  50
VAL A 165
SER A 239
 None
 1.49A 5v1sB-3w9uA:
1.7		 5v1sB-3w9uA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		5 / 12 VAL A 258
ASP A 256
LEU A  13
GLY A 233
LEU A 234
 None
 1.00A 6b0iB-3w9uA:
3.5		 6b0iB-3w9uA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3w9u PUTATIVE LIPASE
(Proteus
mirabilis) 		4 / 7 LEU A  83
LEU A 245
GLY A 181
LEU A 176
 None
 0.76A 6eu9D-3w9uA:
undetectable		 6eu9D-3w9uA:
13.79