SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wai'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		5 / 9 ILE A   9
LEU A 262
VAL A 293
GLY A  16
LEU A 284
 None
 1.25A 1e7aB-3waiA:
undetectable		 1e7aB-3waiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 6 TYR A 708
GLU A 727
PRO A 738
VAL A 745
 None
 1.40A 1q13A-3waiA:
undetectable		 1q13A-3waiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
 1.20A 1wopA-3waiA:
undetectable		 1wopA-3waiA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 8 PHE A  85
LEU A  89
LEU A 290
LEU A 284
 None
 1.02A 2bfpD-3waiA:
undetectable		 2bfpD-3waiA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		4 / 5 THR A 508
ARG A 511
ALA A 561
ARG A 563
 None
 1.22A 2qhfA-3waiA:
undetectable		 2qhfA-3waiA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.08A 2ve3A-3waiA:
undetectable		 2ve3A-3waiA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		5 / 12 LEU A 192
THR A 193
ALA A 346
THR A 345
ILE A 348
 None
 1.23A 3a35A-3waiA:
undetectable		 3a35A-3waiA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
 1.06A 3a51C-3waiA:
undetectable		 3a51C-3waiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 7 VAL A 624
ILE A 574
GLY A 573
LEU A 603
 None
 0.70A 3bjwF-3waiA:
undetectable		 3bjwF-3waiA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.34A 3gv1A-3waiA:
undetectable
3gv1B-3waiA:
undetectable		 3gv1A-3waiA:
11.02
3gv1B-3waiA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		3 / 3 THR A 791
LYS A 681
GLU A 814
 None
 0.90A 3ijdB-3waiA:
undetectable		 3ijdB-3waiA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 7 GLU A 153
TYR A 155
MET A 330
ARG A 344
 None
 0.74A 3jyrA-3waiA:
47.6		 3jyrA-3waiA:
48.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		5 / 12 ALA A 162
GLY A 165
GLY A 191
ALA A 168
TRP A 158
 None
 1.08A 3ou6A-3waiA:
undetectable		 3ou6A-3waiA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		5 / 12 ALA A 162
GLY A 165
GLY A 191
ALA A 168
TRP A 158
 None
 1.07A 3ou6B-3waiA:
undetectable		 3ou6B-3waiA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		5 / 12 ARG A 563
GLY A 546
ASN A 568
HIS A 562
TYR A 523
 None
 1.22A 3qwpA-3waiA:
undetectable		 3qwpA-3waiA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		6 / 11 GLY A 300
ALA A 301
VAL A 259
GLY A 260
THR A  93
PRO A 107
 None
 1.31A 3ufnA-3waiA:
undetectable		 3ufnA-3waiA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.39A 3vywD-3waiA:
undetectable		 3vywD-3waiA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		3 / 3 LYS A 142
LEU A 139
ALA A 141
 None
 0.71A 4ikiA-3waiA:
2.2		 4ikiA-3waiA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-3waiA:
undetectable		 4or0B-3waiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		5 / 11 VAL A 793
VAL A 795
ILE A 864
ILE A 851
LEU A 868
 None
 0.96A 5e4dB-3waiA:
undetectable		 5e4dB-3waiA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		4 / 5 THR A 838
ALA A 797
THR A 798
HIS A 841
 None
 1.12A 5ecmA-3waiA:
undetectable		 5ecmA-3waiA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		5 / 12 VAL A 343
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.26A 5iktB-3waiA:
undetectable		 5iktB-3waiA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 5 ILE A 696
LEU A 682
HIS A 692
VAL A 777
 None
 1.05A 5jmnB-3waiA:
undetectable		 5jmnB-3waiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Archaeoglobus
fulgidus;
Escherichia
coli) 		4 / 8 VAL A 343
GLY A 191
LEU A 195
THR A 193
 None
 1.06A 5sxqB-3waiA:
undetectable		 5sxqB-3waiA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		4 / 5 HIS A 683
SER A 768
TYR A 701
GLY A 769
 None
 1.20A 5yodH-3waiA:
undetectable		 5yodH-3waiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 None
 0.80A 6b58A-3waiA:
undetectable		 6b58A-3waiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE
(Escherichia
coli;
Archaeoglobus
fulgidus) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.44A 6bm5A-3waiA:
undetectable		 6bm5A-3waiA:
19.70