SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3waz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_D_DVAD8_0 (GRAMICIDIN A)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	3 / 3	VAL A 166 VAL A 164 TRP A 64	None ADE A 301 (-3.8A) None	0.92A	1av2C-3wazA: undetectable 1av2D-3wazA: undetectable	1av2C-3wazA: 5.35 1av2D-3wazA: 5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_D_DVAD8_0 (GRAMICIDIN D)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	3 / 3	VAL A 166 VAL A 164 TRP A 64	None ADE A 301 (-3.8A) None	0.93A	1w5uC-3wazA: undetectable 1w5uD-3wazA: undetectable	1w5uC-3wazA: 5.35 1w5uD-3wazA: 5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HYY_B_STIB600_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	4 / 6	LEU A 141 VAL A 187 ILE A 62 MET A 197	None	1.24A	2hyyB-3wazA: undetectable	2hyyB-3wazA: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_A_DVAA8_0 (GRAMICIDIN D)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	3 / 3	VAL A 164 TRP A 64 VAL A 166	ADE A 301 (-3.8A) None None	0.79A	2izqA-3wazA: undetectable 2izqB-3wazA: undetectable	2izqA-3wazA: 5.35 2izqB-3wazA: 5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_A_C2FA314_0 (UNCHARACTERIZED PROTEIN)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	5 / 12	LEU A 78 VAL A 164 GLY A 148 ILE A 206 LEU A 201	None ADE A 301 (-3.8A) None None None	1.09A	3ijdA-3wazA: undetectable	3ijdA-3wazA: 25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_A_C2FA314_0 (UNCHARACTERIZED PROTEIN)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	5 / 12	TYR A 68 VAL A 164 GLY A 148 ILE A 206 LEU A 201	ADE A 301 (-4.2A) ADE A 301 (-3.8A) None None None	0.85A	3ijdA-3wazA: undetectable	3ijdA-3wazA: 25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_B_C2FB314_0 (UNCHARACTERIZED PROTEIN)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	5 / 12	LEU A 78 VAL A 164 GLY A 148 ILE A 206 LEU A 201	None ADE A 301 (-3.8A) None None None	1.13A	3ijdB-3wazA: undetectable	3ijdB-3wazA: 25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_B_C2FB314_0 (UNCHARACTERIZED PROTEIN)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	5 / 12	TYR A 68 VAL A 164 GLY A 148 ILE A 206 LEU A 201	ADE A 301 (-4.2A) ADE A 301 (-3.8A) None None None	0.83A	3ijdB-3wazA: undetectable	3ijdB-3wazA: 25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_B_DVAB8_0 (GRAMICIDIN D)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	3 / 3	VAL A 166 VAL A 164 TRP A 64	None ADE A 301 (-3.8A) None	0.79A	3l8lA-3wazA: undetectable 3l8lB-3wazA: undetectable	3l8lA-3wazA: 5.35 3l8lB-3wazA: 5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_D_DVAD8_0 (GRAMICIDIN D)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	3 / 3	VAL A 166 VAL A 164 TRP A 64	None ADE A 301 (-3.8A) None	0.95A	3l8lC-3wazA: undetectable 3l8lD-3wazA: undetectable	3l8lC-3wazA: 5.35 3l8lD-3wazA: 5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXZ_A_0LIA1_2 (TYROSINE-PROTEIN KINASE ABL1)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	5 / 9	LEU A 141 VAL A 187 ILE A 62 MET A 197 VAL A 19	None	1.41A	3oxzA-3wazA: undetectable	3oxzA-3wazA: 24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1W_A_STRA402_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	4 / 7	VAL A 150 ILE A 149 LEU A 196 LEU A 200	None	0.98A	4l1wA-3wazA: undetectable	4l1wA-3wazA: 22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I8F_A_ML1A211_1 (PHENOLIC OXIDATIVE COUPLING PROTEIN)	3waz	PUTATIVE UNCHARACTERIZED PROTEIN (Pyrococcus abyssi)	4 / 6	VAL A 158 ALA A 154 GLN A 161 TYR A 160	None	1.06A	5i8fA-3wazA: undetectable	5i8fA-3wazA: 21.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AV2_D_DVAD8_0","GRAMICIDIN A","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",3,"VAL A 166;VAL A 164;TRP A  64","None;ADE A 301 (-3.8A);None","0.92A","1av2C-3wazA:undetectable;1av2D-3wazA:undetectable","1av2C-3wazA:5.35;1av2D-3wazA:5.35"],["1W5U_D_DVAD8_0","GRAMICIDIN D","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",3,"VAL A 166;VAL A 164;TRP A  64","None;ADE A 301 (-3.8A);None","0.93A","1w5uC-3wazA:undetectable;1w5uD-3wazA:undetectable","1w5uC-3wazA:5.35;1w5uD-3wazA:5.35"],["2HYY_B_STIB600_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",4,"LEU A 141;VAL A 187;ILE A  62;MET A 197","None","1.24A","2hyyB-3wazA:undetectable","2hyyB-3wazA:22.49"],["2IZQ_A_DVAA8_0","GRAMICIDIN D","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",3,"VAL A 164;TRP A  64;VAL A 166","ADE A 301 (-3.8A);None;None","0.79A","2izqA-3wazA:undetectable;2izqB-3wazA:undetectable","2izqA-3wazA:5.35;2izqB-3wazA:5.35"],["3IJD_A_C2FA314_0","UNCHARACTERIZED PROTEIN","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",5,"LEU A  78;VAL A 164;GLY A 148;ILE A 206;LEU A 201","None;ADE A 301 (-3.8A);None;None;None","1.09A","3ijdA-3wazA:undetectable","3ijdA-3wazA:25.55"],["3IJD_A_C2FA314_0","UNCHARACTERIZED PROTEIN","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",5,"TYR A  68;VAL A 164;GLY A 148;ILE A 206;LEU A 201","ADE A 301 (-4.2A);ADE A 301 (-3.8A);None;None;None","0.85A","3ijdA-3wazA:undetectable","3ijdA-3wazA:25.55"],["3IJD_B_C2FB314_0","UNCHARACTERIZED PROTEIN","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",5,"LEU A  78;VAL A 164;GLY A 148;ILE A 206;LEU A 201","None;ADE A 301 (-3.8A);None;None;None","1.13A","3ijdB-3wazA:undetectable","3ijdB-3wazA:25.55"],["3IJD_B_C2FB314_0","UNCHARACTERIZED PROTEIN","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",5,"TYR A  68;VAL A 164;GLY A 148;ILE A 206;LEU A 201","ADE A 301 (-4.2A);ADE A 301 (-3.8A);None;None;None","0.83A","3ijdB-3wazA:undetectable","3ijdB-3wazA:25.55"],["3L8L_B_DVAB8_0","GRAMICIDIN D","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",3,"VAL A 166;VAL A 164;TRP A  64","None;ADE A 301 (-3.8A);None","0.79A","3l8lA-3wazA:undetectable;3l8lB-3wazA:undetectable","3l8lA-3wazA:5.35;3l8lB-3wazA:5.98"],["3L8L_D_DVAD8_0","GRAMICIDIN D","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",3,"VAL A 166;VAL A 164;TRP A  64","None;ADE A 301 (-3.8A);None","0.95A","3l8lC-3wazA:undetectable;3l8lD-3wazA:undetectable","3l8lC-3wazA:5.35;3l8lD-3wazA:5.98"],["3OXZ_A_0LIA1_2","TYROSINE-PROTEIN KINASE ABL1","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",5,"LEU A 141;VAL A 187;ILE A  62;MET A 197;VAL A  19","None","1.41A","3oxzA-3wazA:undetectable","3oxzA-3wazA:24.41"],["4L1W_A_STRA402_1","ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",4,"VAL A 150;ILE A 149;LEU A 196;LEU A 200","None","0.98A","4l1wA-3wazA:undetectable","4l1wA-3wazA:22.63"],["5I8F_A_ML1A211_1","PHENOLIC OXIDATIVE COUPLING PROTEIN","3waz","PUTATIVE UNCHARACTERIZED PROTEIN","Pyrococcus abyssi",4,"VAL A 158;ALA A 154;GLN A 161;TYR A 160","None","1.06A","5i8fA-3wazA:undetectable","5i8fA-3wazA:21.62"]]