SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wbb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		5 / 12 VAL A 229
GLY A 228
MET A 249
ASN A 253
MET A 152
 None
None
None
NAP  A 305 (-3.6A)
None
 1.32A 1a27A-3wbbA:
8.7		 1a27A-3wbbA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		4 / 6 VAL A  33
GLY A  32
LEU A  30
GLU A  20
 None
 0.62A 1fduD-3wbbA:
8.5		 1fduD-3wbbA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		3 / 3 ASP A 203
HIS A 154
ASP A 209
 None
 0.72A 1nw5A-3wbbA:
2.9		 1nw5A-3wbbA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		5 / 11 VAL A 229
GLU A 232
LEU A 133
ILE A 129
ASP A 126
 None
GOL  A 302 ( 4.7A)
None
None
None
 1.19A 1t6zA-3wbbA:
undetectable		 1t6zA-3wbbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		5 / 11 VAL A 229
GLU A 232
LEU A 133
ILE A 129
ASP A 126
 None
GOL  A 302 ( 4.7A)
None
None
None
 1.11A 1t6zB-3wbbA:
3.2		 1t6zB-3wbbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		5 / 12 ILE A  55
LEU A  58
GLY A  60
ALA A   7
VAL A   8
 None
 0.79A 2oc8A-3wbbA:
undetectable		 2oc8A-3wbbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		3 / 3 GLY A 274
ARG A 109
TYR A 276
 None
 0.79A 2opxA-3wbbA:
2.6		 2opxA-3wbbA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		4 / 8 TYR A  11
ARG A  35
PRO A  44
GLU A  45
 None
NAP  A 305 (-4.2A)
None
None
 1.04A 2ys6A-3wbbA:
5.0		 2ys6A-3wbbA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		5 / 12 LEU A   4
ALA A  64
ALA A 113
GLY A 274
ALA A 269
 None
 1.06A 4enhA-3wbbA:
undetectable		 4enhA-3wbbA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		4 / 5 ARG A 270
GLN A 271
PRO A 282
ILE A 284
 None
 1.48A 4z4hA-3wbbA:
2.2		 4z4hA-3wbbA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		5 / 11 SER A 169
GLY A 153
ALA A 160
VAL A 156
SER A 151
 None
 1.21A 5i3cC-3wbbA:
undetectable		 5i3cC-3wbbA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3wbb DIAMINOPIMELATE
DEHYDROGENASE
(Symbiobacterium
thermophilum) 		5 / 12 VAL A  33
VAL A 262
MET A 261
GLY A  15
LEU A  46
 None
 1.01A 5xxiA-3wbbA:
undetectable		 5xxiA-3wbbA:
17.95