SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 194
ALA A 128
THR A 111
SER A 114
ILE A 115
 None
 1.04A 1ddrA-3wbkA:
undetectable		 1ddrA-3wbkA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 194
THR A 111
SER A 114
ILE A 115
LEU A 177
 None
 0.98A 1ddrA-3wbkA:
undetectable		 1ddrA-3wbkA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 386
ASP A 391
ASP A 416
 None
 0.74A 1sqfA-3wbkA:
undetectable		 1sqfA-3wbkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 592
LEU A 575
ILE A 572
LEU A 566
SER A 565
 None
 0.92A 2bdmA-3wbkA:
undetectable		 2bdmA-3wbkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 567
SER A 571
LEU A 591
PHE A 464
 None
 1.06A 2f78A-3wbkA:
undetectable		 2f78A-3wbkA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 118
THR A 111
LEU A 172
LEU A 177
GLY A 176
 None
 1.31A 3g1uB-3wbkA:
2.3		 3g1uB-3wbkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 118
THR A 111
LEU A 172
LEU A 177
GLY A 176
 None
 1.25A 3g1uD-3wbkA:
2.8		 3g1uD-3wbkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 251
ILE A 250
GLY A  43
ILE A  42
 None
 0.88A 3wxoA-3wbkA:
undetectable		 3wxoA-3wbkA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 194
THR A 111
SER A 114
ILE A 115
LEU A 177
 None
 1.01A 4dfrA-3wbkA:
undetectable		 4dfrA-3wbkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 454
ALA A 402
GLU A 404
GLN A 583
 None
 1.12A 4g0uA-3wbkA:
undetectable		 4g0uA-3wbkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 412
ALA A 367
GLY A  79
SER A 360
GLY A 363
 None
 1.13A 4mmfB-3wbkA:
undetectable		 4mmfB-3wbkA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  42
LEU A 278
ILE A 247
ASP A 248
 None
 0.79A 4rmjA-3wbkA:
2.7		 4rmjA-3wbkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 127
GLY A  17
LEU A  21
THR A  19
 None
 1.00A 5sxtB-3wbkA:
undetectable		 5sxtB-3wbkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 127
GLY A  17
LEU A  21
THR A  19
 None
 0.98A 5syjB-3wbkA:
undetectable		 5syjB-3wbkA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 543
VAL A 517
CYH A 498
CYH A 466
 None
 1.33A 5te0A-3wbkA:
undetectable		 5te0A-3wbkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 173
LEU A 107
ILE A 101
VAL A 192
PHE A 125
 None
 1.23A 5vlmG-3wbkA:
undetectable		 5vlmG-3wbkA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 127
LEU A  99
ARG A 119
VAL A 192
 None
 0.98A 5x7zA-3wbkA:
undetectable		 5x7zA-3wbkA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  75
LEU A  93
ALA A 123
LEU A 118
 None
 0.77A 5y7pE-3wbkA:
undetectable		 5y7pE-3wbkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 359
GLY A 383
SER A 360
GLY A 385
SER A 317
 None
 1.03A 6bklE-3wbkA:
undetectable
6bklF-3wbkA:
undetectable
6bklG-3wbkA:
undetectable
6bklH-3wbkA:
undetectable		 6bklE-3wbkA:
3.70
6bklF-3wbkA:
3.70
6bklG-3wbkA:
3.70
6bklH-3wbkA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 448
LEU A 451
ARG A 455
 None
 0.74A 6d8fA-3wbkA:
5.1		 6d8fA-3wbkA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 436
ALA A 359
LEU A 369
GLY A 363
SER A  82
 None
 1.09A 6ieyA-3wbkA:
undetectable
6ieyB-3wbkA:
3.1		 6ieyA-3wbkA:
20.07
6ieyB-3wbkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 355
VAL A 379
ASP A 441
PHE A 443
ILE A 436
 None
 1.27A 6mxtA-3wbkA:
undetectable		 6mxtA-3wbkA:
23.68