SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wbm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWI_C_115C4_2 (HMG-COA REDUCTASE)	3wbm	DNA/RNA-BINDING PROTEIN ALBA 1 (Sulfolobus shibatae)	4 / 8	GLU A 54 ASN A 58 ALA A 26 LEU A 30	None	0.79A	1hwiD-3wbmA: undetectable	1hwiD-3wbmA: 12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QHF_A_ACTA503_0 (CHORISMATE SYNTHASE)	3wbm	DNA/RNA-BINDING PROTEIN ALBA 1 (Sulfolobus shibatae)	4 / 5	GLN A 75 THR A 89 ARG A 42 ALA A 41	None None C X 13 ( 3.9A) None	1.04A	2qhfA-3wbmA: undetectable	2qhfA-3wbmA: 16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_A_DR7A100_2 (PROTEASE)	3wbm	DNA/RNA-BINDING PROTEIN ALBA 1 (Sulfolobus shibatae)	5 / 9	ALA A 49 ASP A 51 GLY A 15 VAL A 11 ILE A 39	None None C X 12 ( 3.4A) None None	1.12A	3em4B-3wbmA: undetectable	3em4B-3wbmA: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_A_FUAA1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	3wbm	DNA/RNA-BINDING PROTEIN ALBA 1 (Sulfolobus shibatae)	4 / 5	ILE A 90 LYS A 68 ILE A 67 VAL A 53	None	0.98A	5jmnA-3wbmA: undetectable	5jmnA-3wbmA: 6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DIF_B_TPVB201_0 (HIV-1 PROTEASE)	3wbm	DNA/RNA-BINDING PROTEIN ALBA 1 (Sulfolobus shibatae)	5 / 12	ALA A 49 ASP A 51 GLY A 15 VAL A 11 ILE A 39	None None C X 12 ( 3.4A) None None	1.14A	6difA-3wbmA: undetectable	6difA-3wbmA: 26.26

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HWI_C_115C4_2","HMG-COA REDUCTASE;HMG-COA REDUCTASE","3wbm","DNA\/RNA-BINDING PROTEIN ALBA 1","Sulfolobus shibatae",4,"GLU A  54;ASN A  58;ALA A  26;LEU A  30","None","0.79A","1hwiD-3wbmA:undetectable","1hwiD-3wbmA:12.53"],["2QHF_A_ACTA503_0","CHORISMATE SYNTHASE","3wbm","DNA\/RNA-BINDING PROTEIN ALBA 1","Sulfolobus shibatae",4,"GLN A  75;THR A  89;ARG A  42;ALA A  41","None;None;  C X  13 ( 3.9A);None","1.04A","2qhfA-3wbmA:undetectable","2qhfA-3wbmA:16.49"],["3EM4_A_DR7A100_2","PROTEASE;PROTEASE","3wbm","DNA\/RNA-BINDING PROTEIN ALBA 1","Sulfolobus shibatae",5,"ALA A  49;ASP A  51;GLY A  15;VAL A  11;ILE A  39","None;None;  C X  12 ( 3.4A);None;None","1.12A","3em4B-3wbmA:undetectable","3em4B-3wbmA:20.00"],["5JMN_A_FUAA1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","3wbm","DNA\/RNA-BINDING PROTEIN ALBA 1","Sulfolobus shibatae",4,"ILE A  90;LYS A  68;ILE A  67;VAL A  53","None","0.98A","5jmnA-3wbmA:undetectable","5jmnA-3wbmA:6.85"],["6DIF_B_TPVB201_0","HIV-1 PROTEASE","3wbm","DNA\/RNA-BINDING PROTEIN ALBA 1","Sulfolobus shibatae",5,"ALA A  49;ASP A  51;GLY A  15;VAL A  11;ILE A  39","None;None;  C X  12 ( 3.4A);None;None","1.14A","6difA-3wbmA:undetectable","6difA-3wbmA:26.26"]]