SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wbz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		4 / 8 ARG A 143
GLN A 150
PHE A 146
ASN A 144
 None
 1.36A 1zzqA-3wbzA:
undetectable		 1zzqA-3wbzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		5 / 11 TYR A 108
THR A 106
LEU A 126
SER A 101
LEU A 121
 None
 1.36A 2idkA-3wbzA:
undetectable
2idkB-3wbzA:
undetectable
2idkC-3wbzA:
undetectable
2idkD-3wbzA:
undetectable		 2idkA-3wbzA:
19.94
2idkB-3wbzA:
19.94
2idkC-3wbzA:
19.94
2idkD-3wbzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		5 / 10 LEU A 121
SER A 101
LEU A 126
TYR A 108
THR A 106
 None
 1.43A 2idkA-3wbzA:
0.8
2idkB-3wbzA:
0.6
2idkC-3wbzA:
0.4
2idkD-3wbzA:
0.6		 2idkA-3wbzA:
19.94
2idkB-3wbzA:
19.94
2idkC-3wbzA:
19.94
2idkD-3wbzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		4 / 8 ARG A 143
GLN A 150
PHE A 146
ASN A 144
 None
 1.32A 3n62B-3wbzA:
undetectable		 3n62B-3wbzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		4 / 8 ARG A 143
GLN A 150
PHE A 146
ASN A 144
 None
 1.33A 3n66B-3wbzA:
undetectable		 3n66B-3wbzA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		3 / 3 THR A 161
ASN A 157
GLU A 204
 None
 0.74A 3v4tA-3wbzA:
undetectable
3v4tC-3wbzA:
undetectable		 3v4tA-3wbzA:
19.71
3v4tC-3wbzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		5 / 12 LEU A  61
ALA A  58
ILE A 213
ARG A 216
GLY A 211
 None
 1.11A 4dm8B-3wbzA:
undetectable		 4dm8B-3wbzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		4 / 8 ARG A 143
ASP A 257
ASP A 256
ASP A 252
 None
 1.04A 4xqgA-3wbzA:
undetectable		 4xqgA-3wbzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		4 / 8 ARG A 143
ASP A 257
ASP A 256
ASP A 252
 None
 1.05A 4xqgB-3wbzA:
undetectable		 4xqgB-3wbzA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3wbz LIKELY HISTIDYL
TRNA-SPECIFIC
GUANYLYLTRANSFERASE
(Candida
albicans) 		4 / 8 THR A 212
CYH A 153
TYR A  72
LEU A  51
 None
None
None
ATP  A 401 (-4.0A)
 1.31A 6cnjD-3wbzA:
undetectable
6cnjE-3wbzA:
undetectable		 6cnjD-3wbzA:
14.50
6cnjE-3wbzA:
15.69