SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wcs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		4 / 4 VAL A 112
ALA A 110
LEU A  53
PHE A 230
 None
 1.26A 1q97B-3wcsA:
undetectable		 1q97B-3wcsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		4 / 6 LEU A 187
ALA A  90
SER A 250
SER A  28
 EDO  A1007 ( 4.4A)
None
None
None
 0.57A 1tz8C-3wcsA:
undetectable
1tz8D-3wcsA:
undetectable		 1tz8C-3wcsA:
18.75
1tz8D-3wcsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 GLY A 235
GLY A 124
LEU A 126
GLY A 128
ARG A  69
 NAG  A1005 ( 3.8A)
MAN  A1004 (-3.5A)
MAN  A1004 (-4.2A)
None
None
 1.23A 1y4lA-3wcsA:
undetectable		 1y4lA-3wcsA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		4 / 6 THR A  63
THR A  54
ASP A 245
ASN A  96
 None
 1.27A 2okcA-3wcsA:
undetectable		 2okcA-3wcsA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 THR A 173
ALA A 143
ALA A 199
THR A 233
ILE A 168
 None
 1.21A 3dl9B-3wcsA:
undetectable		 3dl9B-3wcsA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		4 / 4 SER A 248
SER A  92
THR A  91
SER A 250
 None
 1.10A 3loqA-3wcsA:
undetectable		 3loqA-3wcsA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		4 / 6 ILE A 168
HIS A 160
LEU A 127
ASP A 164
 None
MN  A1002 (-3.3A)
None
None
 1.25A 3oi8A-3wcsA:
undetectable		 3oi8A-3wcsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		5 / 12 PHE A  89
GLY A 229
ILE A  76
VAL A 226
ALA A 110
 None
None
EDO  A1009 (-4.2A)
None
None
 1.14A 4a6eA-3wcsA:
undetectable		 4a6eA-3wcsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		4 / 5 ILE A 171
LEU A 129
HIS A 140
VAL A 221
 None
 0.86A 5jmnB-3wcsA:
undetectable		 5jmnB-3wcsA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3wcs ERYTHROAGGLUTININ
(Phaseolus
vulgaris) 		3 / 3 GLY A 108
THR A 234
ASN A 244
 None
 0.69A 5odiG-3wcsA:
undetectable		 5odiG-3wcsA:
17.77