SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wct'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		3 / 3 ALA A 113
VAL A 115
TRP A 128
 None
 0.89A 1kqeA-3wctA:
undetectable
1kqeE-3wctA:
undetectable		 1kqeA-3wctA:
5.22
1kqeE-3wctA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		3 / 3 TRP A 128
ALA A 113
VAL A 115
 None
 0.89A 1kqeB-3wctA:
undetectable
1kqeD-3wctA:
undetectable		 1kqeB-3wctA:
5.22
1kqeD-3wctA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 6 PHE A  27
TRP A  14
GLY A 116
GLY A 117
 None
 0.99A 2qr2A-3wctA:
undetectable
2qr2B-3wctA:
undetectable		 2qr2A-3wctA:
22.12
2qr2B-3wctA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 5 TRP A  14
GLY A 116
GLY A 117
PHE A  27
 None
 0.92A 2qr2A-3wctA:
undetectable
2qr2B-3wctA:
undetectable		 2qr2A-3wctA:
22.12
2qr2B-3wctA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 8 LEU A  70
VAL A 115
TYR A 132
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.92A 3v81C-3wctA:
2.1		 3v81C-3wctA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 7 LEU A  70
VAL A 115
TYR A 132
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.91A 4b3qA-3wctA:
undetectable		 4b3qA-3wctA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		5 / 11 ALA A 110
LEU A 111
THR A 114
VAL A 115
TYR A  18
 None
 0.87A 4g1bB-3wctA:
13.3		 4g1bB-3wctA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 8 LEU A  70
VAL A 115
TYR A 132
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.90A 4pwdC-3wctA:
2.4		 4pwdC-3wctA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3wct A1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 8 LEU A  70
VAL A 115
TYR A 132
LEU A  31
 HEM  A 200 ( 4.6A)
None
None
None
 0.85A 4q0bA-3wctA:
undetectable		 4q0bA-3wctA:
13.87