SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 6 THR B  65
LEU B  68
GLY B  70
TYR B  19
 None
None
HEM  B 201 ( 4.1A)
None
 1.04A 1gtiC-3wcuB:
undetectable		 1gtiC-3wcuB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
B2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma;
Lamellibrachia
satsuma) 		5 / 12 TYR B  19
ILE C  69
GLY B  70
GLY C  74
SER C  77
 None
None
HEM  B 201 ( 4.1A)
HEM  C 200 (-3.9A)
None
 1.12A 1kiaA-3wcuB:
undetectable		 1kiaA-3wcuB:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3wcu B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 4 ALA D  96
VAL D 100
ALA D  97
HIS D  94
 None
 1.24A 1q23K-3wcuD:
undetectable		 1q23K-3wcuD:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 4 LYS B  12
LEU B   9
LEU D 124
SER D 123
 None
 1.48A 1tz8D-3wcuB:
undetectable		 1tz8D-3wcuB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		5 / 11 LEU B  88
LEU B  84
ILE B 137
ALA B  76
LEU B  71
 None
None
None
None
HEM  B 201 (-4.4A)
 1.07A 2q72A-3wcuB:
undetectable		 2q72A-3wcuB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		5 / 12 LEU B  88
LEU B  84
ILE B 137
ALA B  76
LEU B  71
 None
None
None
None
HEM  B 201 (-4.4A)
 1.06A 2qb4A-3wcuB:
undetectable		 2qb4A-3wcuB:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		5 / 11 LEU B  88
LEU B  84
ILE B 137
ALA B  76
LEU B  71
 None
None
None
None
HEM  B 201 (-4.4A)
 1.06A 2qjuA-3wcuB:
undetectable		 2qjuA-3wcuB:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 3wcu B2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		3 / 3 HIS C  55
PHE C  37
PHE C  41
 None
 0.75A 3lk0D-3wcuC:
undetectable		 3lk0D-3wcuC:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 8 ALA B 111
PHE B  60
PHE B  37
ALA B  34
 None
 0.92A 3t3sF-3wcuB:
undetectable		 3t3sF-3wcuB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3wcu B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		5 / 7 PHE D  41
VAL D 116
PHE D  64
GLY D  33
THR D  68
 None
 1.34A 4ejjB-3wcuD:
undetectable		 4ejjB-3wcuD:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
B2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		3 / 3 ASP B  72
TYR B  19
TRP C  21
 None
 1.38A 4p7nA-3wcuB:
undetectable		 4p7nA-3wcuB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
B2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		3 / 3 GLN B  94
HIS B  90
ARG C  70
 HEM  C 200 ( 3.6A)
HEM  C 200 (-4.1A)
None
 1.29A 4qyqA-3wcuB:
undetectable		 4qyqA-3wcuB:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3wcu B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		4 / 5 LEU D 105
MET D 113
LEU D  40
HIS D  67
 HEM  D 201 (-4.6A)
None
None
HEM  D 201 ( 4.6A)
 1.29A 4xi3B-3wcuD:
undetectable		 4xi3B-3wcuD:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		5 / 10 ASP B  72
VAL B 112
GLY B  20
PHE B  28
GLY B  29
 None
 1.33A 4xpbA-3wcuB:
undetectable		 4xpbA-3wcuB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 3wcu B2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN
(Lamellibrachia
satsuma) 		5 / 10 ALA C  33
ALA C  35
VAL C 120
VAL C 124
TRP C  21
 None
 1.42A 5eb5B-3wcuC:
undetectable		 5eb5B-3wcuC:
14.15