SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wcx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 8 TYR A 112
ASP A  88
VAL A  90
GLY A  86
 None
 0.98A 1ekjA-3wcxA:
undetectable
1ekjB-3wcxA:
undetectable		 1ekjA-3wcxA:
21.50
1ekjB-3wcxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 6 TYR A 112
ASP A  88
VAL A  90
GLY A  86
 None
 1.13A 1ekjC-3wcxA:
undetectable
1ekjD-3wcxA:
2.0		 1ekjC-3wcxA:
21.50
1ekjD-3wcxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 6 ASP A  88
VAL A  90
GLY A  86
TYR A 112
 None
 1.13A 1ekjC-3wcxA:
undetectable
1ekjD-3wcxA:
1.8		 1ekjC-3wcxA:
21.50
1ekjD-3wcxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 8 GLY A 172
ILE A 158
ASN A 160
GLN A 214
 None
EPE  A 401 (-4.9A)
None
None
 1.02A 2a8tB-3wcxA:
undetectable		 2a8tB-3wcxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 8 HIS A 331
GLY A 330
TYR A 279
ARG A 278
 SIN  A 402 (-3.8A)
None
SIN  A 402 (-4.8A)
SIN  A 402 (-3.5A)
 1.06A 3ccfA-3wcxA:
2.1		 3ccfA-3wcxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		5 / 10 THR A  58
ASN A  57
HIS A 191
GLY A 234
ALA A  95
 None
SIN  A 402 ( 4.1A)
SIN  A 402 (-4.1A)
None
None
 1.41A 3pp7B-3wcxA:
undetectable		 3pp7B-3wcxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 8 LEU A 104
VAL A  90
TYR A  56
LEU A  60
 None
 1.10A 3v81A-3wcxA:
undetectable		 3v81A-3wcxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 8 LEU A 104
VAL A  90
TYR A  56
LEU A  60
 None
 1.10A 3v81C-3wcxA:
undetectable		 3v81C-3wcxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 7 ASP A 196
ASN A 237
GLU A 285
GLU A  94
 None
SIN  A 402 (-2.9A)
None
SIN  A 402 ( 4.1A)
 1.18A 4feuB-3wcxA:
undetectable		 4feuB-3wcxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 7 ASP A 235
ASP A 196
ASN A 237
GLU A 285
 SIN  A 402 (-2.7A)
None
SIN  A 402 (-2.9A)
None
 1.18A 4feuB-3wcxA:
undetectable		 4feuB-3wcxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 6 ASP A 288
ASN A 272
ALA A 275
ASP A 235
 None
None
None
SIN  A 402 (-2.7A)
 1.16A 4mdbA-3wcxA:
undetectable		 4mdbA-3wcxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		6 / 12 ASP A 140
LEU A 104
GLY A 141
GLY A 142
ALA A 101
LEU A  60
 None
 1.42A 4n09C-3wcxA:
undetectable		 4n09C-3wcxA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		5 / 7 ALA A  79
ALA A  75
ALA A 101
LEU A 146
ALA A 108
 None
 1.06A 4z90F-3wcxA:
undetectable
4z90G-3wcxA:
undetectable
4z90H-3wcxA:
undetectable
4z90J-3wcxA:
undetectable		 4z90F-3wcxA:
22.59
4z90G-3wcxA:
22.59
4z90H-3wcxA:
22.59
4z90J-3wcxA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 6 ASP A 235
HIS A 191
LEU A 287
HIS A 331
 SIN  A 402 (-2.7A)
SIN  A 402 (-4.1A)
SIN  A 402 (-4.7A)
SIN  A 402 (-3.8A)
 0.98A 5nelB-3wcxA:
undetectable
5nelC-3wcxA:
undetectable		 5nelB-3wcxA:
21.22
5nelC-3wcxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		5 / 12 GLN A 115
THR A 116
THR A 144
VAL A 143
THR A 190
 None
 1.46A 6ak3A-3wcxA:
undetectable		 6ak3A-3wcxA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 5 PRO A  49
VAL A 180
GLY A 189
VAL A  53
 None
 1.12A 6ak3B-3wcxA:
undetectable		 6ak3B-3wcxA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		4 / 6 GLY A 262
SER A 259
ARG A 260
ARG A 303
 None
 1.21A 6dwdA-3wcxA:
undetectable
6dwdC-3wcxA:
undetectable		 6dwdA-3wcxA:
20.29
6dwdC-3wcxA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		5 / 10 GLY A 172
GLY A 141
ASP A 166
THR A 190
ILE A 215
 None
 1.18A 6exiA-3wcxA:
undetectable		 6exiA-3wcxA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		5 / 10 GLY A 172
GLY A 141
ASP A 166
THR A 190
ILE A 215
 None
 1.16A 6exiB-3wcxA:
undetectable		 6exiB-3wcxA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		5 / 12 GLY A 172
GLY A 141
ASP A 166
THR A 190
ILE A 215
 None
 1.19A 6exiC-3wcxA:
undetectable
6exiD-3wcxA:
undetectable		 6exiC-3wcxA:
12.64
6exiD-3wcxA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3wcx SPHINGOMYELINASE C
(Streptomyces
griseocarneus) 		5 / 12 GLY A 172
GLY A 141
ASP A 166
THR A 190
ILE A 215
 None
 1.17A 6exiC-3wcxA:
undetectable
6exiD-3wcxA:
undetectable		 6exiC-3wcxA:
12.64
6exiD-3wcxA:
12.64