SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 4 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.32A 1h1dA-3wcyA:
undetectable		 1h1dA-3wcyA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		3 / 3 TRP A 144
TYR A 172
LEU A 109
 None
 0.89A 1kxhA-3wcyA:
undetectable		 1kxhA-3wcyA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 5 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.30A 1vidA-3wcyA:
undetectable		 1vidA-3wcyA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 6 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.29A 2cl5B-3wcyA:
undetectable		 2cl5B-3wcyA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 6 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.28A 2zvjA-3wcyA:
undetectable		 2zvjA-3wcyA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		3 / 3 SER A 245
GLU A 106
ASP A 126
 None
 0.87A 3bwmA-3wcyA:
undetectable		 3bwmA-3wcyA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 8 GLY A 276
ASP A 300
ILE A 299
GLN A 270
 None
 0.65A 3fi0B-3wcyA:
undetectable		 3fi0B-3wcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 8 GLY A 276
ASP A 300
ILE A 299
GLN A 270
 None
 0.71A 3fi0G-3wcyA:
undetectable		 3fi0G-3wcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 7 GLY A 276
ASP A 300
ILE A 299
GLN A 270
 None
 0.70A 3fi0P-3wcyA:
undetectable		 3fi0P-3wcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 8 TYR A 370
VAL A 372
MET A 352
ILE A 339
 None
 0.88A 4a97C-3wcyA:
undetectable		 4a97C-3wcyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 8 TYR A 370
VAL A 372
MET A 352
ILE A 339
 None
 0.90A 4a97G-3wcyA:
undetectable		 4a97G-3wcyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 8 TYR A 370
VAL A 372
MET A 352
ILE A 339
 None
 0.96A 4a97I-3wcyA:
2.0		 4a97I-3wcyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		5 / 11 TRP A 130
GLY A 124
ILE A 179
TYR A 189
PRO A 105
 None
 1.41A 4rtrA-3wcyA:
undetectable		 4rtrA-3wcyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 4 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.28A 4xucA-3wcyA:
undetectable		 4xucA-3wcyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		3 / 3 SER A 245
GLU A 106
ASP A 126
 None
 0.82A 4xudA-3wcyA:
undetectable		 4xudA-3wcyA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 5 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.30A 5fhrA-3wcyA:
undetectable		 5fhrA-3wcyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3wcy INTERFERON
ALPHA/BETA RECEPTOR
1
(Mus
musculus) 		4 / 5 SER A 245
GLU A 106
SER A 103
ASP A 126
 None
 1.30A 5fhrB-3wcyA:
undetectable		 5fhrB-3wcyA:
19.29