SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 11 LEU A 116
GLY A 156
VAL A 169
LEU A 168
LEU A  10
 None
None
EDO  A 402 ( 4.4A)
None
None
 1.14A 1mx1A-3wczA:
undetectable		 1mx1A-3wczA:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 12 TRP A  89
HIS A 120
GLU A 182
TYR A 206
SER A 207
 None
NAP  A 401 (-4.0A)
None
NAP  A 401 (-3.2A)
NAP  A 401 (-2.8A)
 0.35A 1s2aA-3wczA:
42.3		 1s2aA-3wczA:
40.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 7 ALA A  55
TYR A  58
MET A 204
HIS A 120
 None
CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
 1.06A 2pncA-3wczA:
undetectable		 2pncA-3wczA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 7 ALA A 205
ILE A 255
ILE A 257
HIS A  51
 None
None
NAP  A 401 (-3.5A)
None
 1.11A 2zm7A-3wczA:
undetectable		 2zm7A-3wczA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 8 SER A 105
THR A  86
ALA A 146
ALA A 152
 None
 0.95A 3ns1L-3wczA:
undetectable		 3ns1L-3wczA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 8 SER A 105
THR A  86
LEU A  88
ALA A 146
 None
 0.97A 3ns1L-3wczA:
undetectable		 3ns1L-3wczA:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 12 TYR A  58
TRP A  89
HIS A 120
ASN A 159
TYR A 206
 CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
NAP  A 401 ( 2.8A)
NAP  A 401 (-3.2A)
 0.19A 3r43A-3wczA:
42.5		 3r43A-3wczA:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 10 TYR A  58
HIS A 120
ASN A 159
TYR A 206
PRO A 307
 CIT  A 406 ( 3.2A)
NAP  A 401 (-4.0A)
NAP  A 401 ( 2.8A)
NAP  A 401 (-3.2A)
EDO  A 405 ( 4.0A)
 0.31A 3r58A-3wczA:
42.5		 3r58A-3wczA:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 12 TYR A  58
TRP A  89
HIS A 120
ASN A 159
TYR A 206
 CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
NAP  A 401 ( 2.8A)
NAP  A 401 (-3.2A)
 0.23A 3r6iA-3wczA:
42.7		 3r6iA-3wczA:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 9 TYR A  58
HIS A 120
ASN A 159
TYR A 206
PRO A 307
 CIT  A 406 ( 3.2A)
NAP  A 401 (-4.0A)
NAP  A 401 ( 2.8A)
NAP  A 401 (-3.2A)
EDO  A 405 ( 4.0A)
 0.36A 3r8gA-3wczA:
42.6		 3r8gA-3wczA:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 12 TYR A  58
HIS A 120
ASN A 159
TYR A 206
PRO A 307
 CIT  A 406 ( 3.2A)
NAP  A 401 (-4.0A)
NAP  A 401 ( 2.8A)
NAP  A 401 (-3.2A)
EDO  A 405 ( 4.0A)
 0.43A 3r94A-3wczA:
42.5		 3r94A-3wczA:
40.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		3 / 3 HIS A 292
SER A 207
GLU A 182
 None
NAP  A 401 (-2.8A)
None
 0.73A 3s8pA-3wczA:
undetectable		 3s8pA-3wczA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		7 / 12 TYR A  58
TRP A  89
HIS A 120
ASN A 159
TYR A 206
SER A 207
PRO A 307
 CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
NAP  A 401 ( 2.8A)
NAP  A 401 (-3.2A)
NAP  A 401 (-2.8A)
EDO  A 405 ( 4.0A)
 0.56A 3ug8A-3wczA:
42.6		 3ug8A-3wczA:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 7 TYR A  58
ASN A 159
GLU A 182
PRO A 307
 CIT  A 406 ( 3.2A)
NAP  A 401 ( 2.8A)
None
EDO  A 405 ( 4.0A)
 0.66A 3ugrA-3wczA:
42.4		 3ugrA-3wczA:
40.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 12 ILE A 119
VAL A  98
ALA A  56
ILE A 114
LEU A 109
 None
 1.16A 3w67C-3wczA:
undetectable		 3w67C-3wczA:
22.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 8 VAL A  57
TYR A  58
TRP A  89
HIS A 120
 None
CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
 0.46A 4jq1B-3wczA:
42.7		 4jq1B-3wczA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 8 VAL A  57
TYR A  58
TRP A  89
HIS A 120
 None
CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
 0.19A 4jtrA-3wczA:
42.6		 4jtrA-3wczA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 6 VAL A  57
TYR A  58
TRP A  89
HIS A 120
 None
CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
 0.21A 4jtrB-3wczA:
42.7		 4jtrB-3wczA:
42.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 9 TYR A  58
TRP A  89
HIS A 120
ASN A 159
TYR A 206
 CIT  A 406 ( 3.2A)
None
NAP  A 401 (-4.0A)
NAP  A 401 ( 2.8A)
NAP  A 401 (-3.2A)
 0.23A 4yvvA-3wczA:
42.6		 4yvvA-3wczA:
40.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 5 THR A  54
ALA A  55
THR A  86
TYR A 117
 None
 1.06A 5ecmA-3wczA:
1.5		 5ecmA-3wczA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 6 THR A  54
ALA A  55
THR A  86
TYR A 117
 None
 0.99A 5ecoA-3wczA:
1.9		 5ecoA-3wczA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		3 / 3 MET A 143
GLN A 144
ARG A 147
 None
 1.08A 5ewzB-3wczA:
undetectable		 5ewzB-3wczA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		5 / 9 GLY A  67
VAL A  41
ALA A  44
VAL A  77
LEU A  82
 None
 1.05A 5lw1H-3wczA:
undetectable		 5lw1H-3wczA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		3 / 3 MET A 143
GLN A 144
ARG A 147
 None
 1.09A 5m35B-3wczA:
undetectable		 5m35B-3wczA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		3 / 3 MET A 143
GLN A 144
ARG A 147
 None
 1.12A 5m36A-3wczA:
undetectable		 5m36A-3wczA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		4 / 6 TYR A 117
GLN A 180
GLU A  61
ALA A 101
 None
NAP  A 401 (-3.3A)
None
None
 1.23A 6djzB-3wczA:
undetectable		 6djzB-3wczA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		3 / 3 MET A 143
GLN A 144
ARG A 147
 None
 1.12A 6fn9A-3wczA:
undetectable		 6fn9A-3wczA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		3 / 3 MET A 143
GLN A 144
ARG A 147
 None
 1.15A 6fnaB-3wczA:
undetectable		 6fnaB-3wczA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3wcz ALDO-KETO REDUCTASE
2E
(Bombyx
mori) 		3 / 3 MET A 143
GLN A 144
ARG A 147
 None
 1.12A 6fnbA-3wczA:
undetectable		 6fnbA-3wczA:
19.68