SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wd7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 VAL  A 382 ( 0.6A)
LEU  A 370 ( 0.5A)
VAL  A 224 ( 0.6A)
ILE  A  19 ( 0.7A)
ILE  A  22 ( 0.7A)
 0.97A 1epbA-3wd7A:
undetectable		 1epbA-3wd7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 VAL  A 382 ( 0.6A)
LEU  A 370 ( 0.5A)
VAL  A 224 ( 0.6A)
ILE  A  19 ( 0.7A)
ILE  A  22 ( 0.7A)
 0.83A 1epbB-3wd7A:
undetectable		 1epbB-3wd7A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 11 LEU A 222
ALA A 113
GLU A 116
ARG A 234
LEU A 187
 LEU  A 222 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 116 ( 0.5A)
ARG  A 234 ( 0.6A)
LEU  A 187 ( 0.5A)
 1.21A 1g50A-3wd7A:
undetectable		 1g50A-3wd7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 9 ALA A 174
GLY A 225
ALA A  17
LEU A 384
LEU A 171
 ALA  A 174 ( 0.0A)
GLY  A 225 ( 0.0A)
ALA  A  17 ( 0.0A)
LEU  A 384 ( 0.6A)
LEU  A 171 ( 0.5A)
 1.17A 1nr6A-3wd7A:
undetectable		 1nr6A-3wd7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 10 LEU A 222
ALA A  21
LEU A 236
LEU A 346
ILE A 239
 LEU  A 222 ( 0.6A)
ALA  A  21 ( 0.0A)
LEU  A 236 ( 0.6A)
LEU  A 346 ( 0.6A)
ILE  A 239 ( 0.7A)
 1.29A 1pcgA-3wd7A:
undetectable		 1pcgA-3wd7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 SER A 327
ILE A 301
GLY A 167
VAL A 382
ALA A 242
 SER  A 327 ( 0.0A)
ILE  A 301 ( 0.4A)
GLY  A 167 ( 0.0A)
VAL  A 382 ( 0.6A)
ALA  A 242 ( 0.0A)
 1.13A 1tsnA-3wd7A:
undetectable		 1tsnA-3wd7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 10 LEU A 222
ALA A 113
GLU A 116
ARG A 234
LEU A 187
 LEU  A 222 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 116 ( 0.5A)
ARG  A 234 ( 0.6A)
LEU  A 187 ( 0.5A)
 1.25A 2ocfA-3wd7A:
undetectable		 2ocfA-3wd7A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 ILE  A 223 ( 0.7A)
ALA  A 110 ( 0.0A)
LEU  A 144 ( 0.5A)
ILE  A 124 ( 0.7A)
 0.73A 2w9sE-3wd7A:
undetectable		 2w9sE-3wd7A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 PHE A 275
ILE A 309
PRO A 375
GLY A 374
 PHE  A 275 ( 1.3A)
ILE  A 309 ( 0.7A)
PRO  A 375 ( 1.1A)
GLY  A 374 ( 0.0A)
 0.92A 2y7kA-3wd7A:
undetectable		 2y7kA-3wd7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 VAL  A 342 ( 0.6A)
VAL  A 369 ( 0.6A)
PHE  A 371 ( 1.3A)
HIS  A 303 ( 1.0A)
 1.02A 3fhxB-3wd7A:
undetectable		 3fhxB-3wd7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 SER A  98
GLY A 139
ALA A 140
LEU A 144
LEU A 147
 SER  A  98 ( 0.0A)
GLY  A 139 ( 0.0A)
ALA  A 140 ( 0.0A)
LEU  A 144 ( 0.5A)
LEU  A 147 ( 0.6A)
 1.05A 3hs6A-3wd7A:
undetectable		 3hs6A-3wd7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 LEU A  59
GLY A 335
ALA A 216
THR A 194
 LEU  A  59 (-0.5A)
GLY  A 335 ( 0.0A)
ALA  A 216 ( 0.0A)
THR  A 194 ( 0.8A)
 0.76A 3jusA-3wd7A:
undetectable		 3jusA-3wd7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 LEU A  59
GLY A 335
ALA A 216
THR A 194
 LEU  A  59 (-0.5A)
GLY  A 335 ( 0.0A)
ALA  A 216 ( 0.0A)
THR  A 194 ( 0.8A)
 0.76A 3jusA-3wd7A:
undetectable		 3jusA-3wd7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 LEU A 222
ALA A 113
GLU A 116
ARG A 234
LEU A 187
 LEU  A 222 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 116 ( 0.5A)
ARG  A 234 ( 0.6A)
LEU  A 187 ( 0.5A)
 1.17A 3olsB-3wd7A:
undetectable		 3olsB-3wd7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 HIS A 385
SER A 386
THR A 360
ASP A 227
 HIS  A 385 ( 1.0A)
SER  A 386 ( 0.0A)
THR  A 360 ( 0.8A)
ASP  A 227 ( 0.6A)
 1.14A 3tm4A-3wd7A:
undetectable		 3tm4A-3wd7A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 HIS A 385
SER A 386
THR A 360
ASP A 227
 HIS  A 385 ( 1.0A)
SER  A 386 ( 0.0A)
THR  A 360 ( 0.8A)
ASP  A 227 ( 0.6A)
 1.13A 3tm4B-3wd7A:
undetectable		 3tm4B-3wd7A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 189
LEU A 187
ILE A 128
ASP A 141
 VAL  A 189 ( 0.6A)
LEU  A 187 ( 0.5A)
ILE  A 128 ( 0.7A)
ASP  A 141 ( 0.6A)
 0.70A 3wzeA-3wd7A:
undetectable		 3wzeA-3wd7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 SER A 327
ILE A 301
GLY A 167
VAL A 382
ALA A 242
 SER  A 327 ( 0.0A)
ILE  A 301 ( 0.4A)
GLY  A 167 ( 0.0A)
VAL  A 382 ( 0.6A)
ALA  A 242 ( 0.0A)
 1.20A 4foxD-3wd7A:
undetectable		 4foxD-3wd7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 9 ILE A 148
THR A 145
LEU A 144
VAL A 186
LEU A 187
 ILE  A 148 ( 0.7A)
THR  A 145 ( 0.8A)
LEU  A 144 ( 0.5A)
VAL  A 186 ( 0.6A)
LEU  A 187 ( 0.5A)
 1.13A 4g1bC-3wd7A:
undetectable		 4g1bC-3wd7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 VAL A  31
GLN A  33
TYR A  36
MET A  70
 VAL  A  31 ( 0.6A)
GLN  A  33 ( 0.6A)
TYR  A  36 ( 1.3A)
MET  A  70 ( 0.0A)
 1.16A 4hxyB-3wd7A:
undetectable		 4hxyB-3wd7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 ALA A 242
ILE A 128
ILE A 159
GLY A 167
ALA A 168
 ALA  A 242 ( 0.0A)
ILE  A 128 ( 0.7A)
ILE  A 159 ( 0.7A)
GLY  A 167 ( 0.0A)
ALA  A 168 ( 0.0A)
 1.13A 4nkvA-3wd7A:
undetectable		 4nkvA-3wd7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 ALA A 242
ILE A 128
ILE A 159
GLY A 167
ALA A 168
 ALA  A 242 ( 0.0A)
ILE  A 128 ( 0.7A)
ILE  A 159 ( 0.7A)
GLY  A 167 ( 0.0A)
ALA  A 168 ( 0.0A)
 1.12A 4nkvC-3wd7A:
undetectable		 4nkvC-3wd7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 ALA A 242
ILE A 128
ILE A 159
GLY A 167
ALA A 168
 ALA  A 242 ( 0.0A)
ILE  A 128 ( 0.7A)
ILE  A 159 ( 0.7A)
GLY  A 167 ( 0.0A)
ALA  A 168 ( 0.0A)
 1.10A 4nkvD-3wd7A:
undetectable		 4nkvD-3wd7A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 GLY A 372
LEU A 384
LEU A 343
LEU A 324
 GLY  A 372 ( 0.0A)
LEU  A 384 ( 0.6A)
LEU  A 343 ( 0.6A)
LEU  A 324 ( 0.5A)
 0.88A 4o8fA-3wd7A:
undetectable		 4o8fA-3wd7A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 PRO A 196
THR A 197
ARG A  94
SER A 208
GLY A 200
 PRO  A 196 ( 1.1A)
THR  A 197 ( 0.8A)
ARG  A  94 ( 0.6A)
SER  A 208 ( 0.0A)
GLY  A 200 ( 0.0A)
 1.32A 4q15A-3wd7A:
undetectable		 4q15A-3wd7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 PRO A 196
THR A 197
ARG A  94
SER A 208
GLY A 200
 PRO  A 196 ( 1.1A)
THR  A 197 ( 0.8A)
ARG  A  94 ( 0.6A)
SER  A 208 ( 0.0A)
GLY  A 200 ( 0.0A)
 1.32A 4q15B-3wd7A:
undetectable		 4q15B-3wd7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 11 GLY A 305
GLY A 306
GLY A 163
ILE A 254
PHE A 275
 GLY  A 305 (-0.0A)
GLY  A 306 (-0.0A)
GLY  A 163 ( 0.0A)
ILE  A 254 ( 0.7A)
PHE  A 275 ( 1.3A)
 1.09A 4qoiA-3wd7A:
undetectable
4qoiB-3wd7A:
undetectable		 4qoiA-3wd7A:
22.31
4qoiB-3wd7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 TYR A 165
GLN A 162
SER A 132
ASP A 207
 TYR  A 165 ( 1.3A)
GLN  A 162 ( 0.6A)
SER  A 132 ( 0.0A)
ASP  A 207 ( 0.6A)
 1.06A 4qtuB-3wd7A:
undetectable		 4qtuB-3wd7A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 PRO A 196
THR A 197
ARG A  94
SER A 208
GLY A 200
 PRO  A 196 ( 1.1A)
THR  A 197 ( 0.8A)
ARG  A  94 ( 0.6A)
SER  A 208 ( 0.0A)
GLY  A 200 ( 0.0A)
 1.29A 4ydqB-3wd7A:
undetectable		 4ydqB-3wd7A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 GLY A 256
ILE A 258
THR A 264
GLY A 262
GLY A 211
 GLY  A 256 ( 0.0A)
ILE  A 258 ( 0.4A)
THR  A 264 ( 0.8A)
GLY  A 262 ( 0.0A)
GLY  A 211 ( 0.0A)
 1.11A 5d4uA-3wd7A:
undetectable		 5d4uA-3wd7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 10 LEU A 222
ALA A 113
GLU A 116
ARG A 234
LEU A 187
 LEU  A 222 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 116 ( 0.5A)
ARG  A 234 ( 0.6A)
LEU  A 187 ( 0.5A)
 1.23A 5dxbA-3wd7A:
undetectable		 5dxbA-3wd7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 TYR A  39
TYR A  36
GLY A 200
LEU A  77
 TYR  A  39 ( 1.3A)
TYR  A  36 ( 1.3A)
GLY  A 200 ( 0.0A)
LEU  A  77 ( 0.5A)
 0.88A 5esfA-3wd7A:
undetectable		 5esfA-3wd7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_SALA601_1
(SALICYLATE-AMP
LIGASE)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 9 PHE A 373
GLY A 372
VAL A 379
GLY A 374
LEU A 377
 PHE  A 373 ( 1.3A)
GLY  A 372 ( 0.0A)
VAL  A 379 ( 0.6A)
GLY  A 374 ( 0.0A)
LEU  A 377 ( 0.6A)
 1.33A 5wm2A-3wd7A:
0.0		 5wm2A-3wd7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 VAL A 382
GLY A 372
ALA A 168
LEU A 346
LEU A 384
 VAL  A 382 ( 0.6A)
GLY  A 372 ( 0.0A)
ALA  A 168 ( 0.0A)
LEU  A 346 ( 0.6A)
LEU  A 384 ( 0.6A)
 1.37A 5x23A-3wd7A:
undetectable		 5x23A-3wd7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 LEU A 247
GLY A 372
LEU A 324
ILE A 309
LEU A 384
 LEU  A 247 ( 0.6A)
GLY  A 372 ( 0.0A)
LEU  A 324 ( 0.5A)
ILE  A 309 ( 0.7A)
LEU  A 384 ( 0.6A)
 1.03A 5ycnA-3wd7A:
undetectable		 5ycnA-3wd7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE
(Citrus
x
microcarpa) 		3 / 3 GLU A 179
ASP A 227
PRO A 228
 GLU  A 179 ( 0.6A)
ASP  A 227 ( 0.6A)
PRO  A 228 ( 1.1A)
 0.31A 6berA-3wd7A:
undetectable		 6berA-3wd7A:
3.86