SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wd8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 HIS A 303
SER A 191
LEU A 105
GLY A 216
 None
 1.00A 1a4lB-3wd8A:
undetectable		 1a4lB-3wd8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 PHE A  31
TYR A  36
VAL A  43
VAL A  76
 None
 1.48A 1dz6B-3wd8A:
undetectable		 1dz6B-3wd8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.92A 1epbA-3wd8A:
undetectable		 1epbA-3wd8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 VAL A 382
LEU A 370
VAL A 224
ILE A  19
ILE A  22
 None
 0.83A 1epbB-3wd8A:
undetectable		 1epbB-3wd8A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 342
SER A 341
ASN A 336
ASP A 192
 None
 1.21A 1hwiB-3wd8A:
undetectable		 1hwiB-3wd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 342
SER A 341
ASN A 336
ASP A 192
 None
 1.22A 1hwkA-3wd8A:
undetectable		 1hwkA-3wd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 342
SER A 341
ASN A 336
ASP A 192
 None
 1.23A 1hwkC-3wd8A:
undetectable		 1hwkC-3wd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 342
SER A 341
ASN A 336
ASP A 192
 None
 1.23A 1hwkD-3wd8A:
undetectable		 1hwkD-3wd8A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		3 / 3 HIS A 126
ASP A 141
ASN A 146
 None
 0.86A 1wg8B-3wd8A:
undetectable		 1wg8B-3wd8A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 11 SER A 242
GLU A 380
GLY A 168
ILE A 171
VAL A 186
 None
 1.16A 2uxpB-3wd8A:
undetectable		 2uxpB-3wd8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 ILE A 166
ALA A 372
LEU A 370
PHE A 190
 None
 0.80A 2w9sE-3wd8A:
undetectable		 2w9sE-3wd8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 ILE A 223
ALA A 110
LEU A 144
ILE A 124
 None
 0.80A 2w9sE-3wd8A:
undetectable		 2w9sE-3wd8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		3 / 3 GLU A 179
SER A 242
VAL A 382
 None
 0.75A 3eeoA-3wd8A:
undetectable		 3eeoA-3wd8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.04A 3fhxB-3wd8A:
undetectable		 3fhxB-3wd8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 MET A 263
LEU A  91
GLN A  95
VAL A 102
 None
 1.07A 3jwqC-3wd8A:
undetectable		 3jwqC-3wd8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 GLY A 374
CYH A 173
GLY A 339
PHE A 190
 None
 0.90A 3ko0M-3wd8A:
undetectable
3ko0P-3wd8A:
undetectable		 3ko0M-3wd8A:
14.36
3ko0P-3wd8A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 8 GLY A 374
CYH A 173
GLY A 339
PHE A 190
 None
 0.97A 3ko0O-3wd8A:
undetectable
3ko0Q-3wd8A:
undetectable		 3ko0O-3wd8A:
14.36
3ko0Q-3wd8A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 11 ILE A 309
SER A 246
ILE A 254
VAL A 271
GLY A 376
 None
 0.91A 3kw4A-3wd8A:
undetectable		 3kw4A-3wd8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 11 ILE A 279
PHE A 371
SER A 241
ILE A 383
LEU A 283
 None
 1.15A 3qg2B-3wd8A:
undetectable		 3qg2B-3wd8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 9 ALA A 131
ASP A 192
ILE A 193
GLY A 106
ILE A  99
 None
 0.99A 3s53A-3wd8A:
undetectable		 3s53A-3wd8A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 12 TYR A 334
GLY A 216
PHE A  31
ASN A  26
GLU A 333
 None
 1.32A 3s8pA-3wd8A:
undetectable		 3s8pA-3wd8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 GLU A 233
SER A 231
ARG A 185
PRO A 228
 None
 1.45A 4k17B-3wd8A:
undetectable		 4k17B-3wd8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 5 LEU A 319
ASP A 294
TRP A 295
ILE A 292
 None
 1.30A 4mwrA-3wd8A:
undetectable		 4mwrA-3wd8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		3 / 3 LYS A  11
ARG A 185
VAL A 186
 None
 0.98A 4x3uA-3wd8A:
undetectable
4x3uB-3wd8A:
undetectable		 4x3uA-3wd8A:
11.19
4x3uB-3wd8A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 HIS A 303
ILE A 345
VAL A 302
ARG A 328
 None
 1.18A 5kkzC-3wd8A:
undetectable
5kkzE-3wd8A:
undetectable		 5kkzC-3wd8A:
19.35
5kkzE-3wd8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 HIS A 303
ILE A 345
VAL A 302
ARG A 328
 None
 1.13A 5kkzK-3wd8A:
undetectable
5kkzQ-3wd8A:
undetectable		 5kkzK-3wd8A:
24.02
5kkzQ-3wd8A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 HIS A 303
ILE A 345
VAL A 302
ARG A 328
 None
 1.20A 5kkzM-3wd8A:
undetectable
5kkzO-3wd8A:
undetectable		 5kkzM-3wd8A:
19.35
5kkzO-3wd8A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		5 / 9 SER A  13
GLY A 225
LEU A  20
GLU A 179
SER A  18
 None
 1.31A 5vw4A-3wd8A:
undetectable		 5vw4A-3wd8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		3 / 3 GLU A 179
ASP A 227
PRO A 228
 None
 0.51A 6berA-3wd8A:
undetectable		 6berA-3wd8A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 SER A 341
HIS A 303
GLY A 339
LEU A 331
 None
 0.91A 6btxA-3wd8A:
undetectable		 6btxA-3wd8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE
(Citrus
x
microcarpa) 		4 / 7 TYR A  40
LEU A  77
TYR A  36
VAL A  72
 None
 1.32A 6g2pA-3wd8A:
undetectable		 6g2pA-3wd8A:
23.17