SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3wdg URACIL-DNA
GLYCOSYLASE
UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus;
Staphylococcus
aureus) 		4 / 7 LEU B  77
ILE B  28
THR B  53
GLN A  58
 None
 1.29A 1kglA-3wdgB:
undetectable		 1kglA-3wdgB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXF_C_MTXC3278_1
(PTERIDINE REDUCTASE
2)		 3wdg UNCHARACTERIZED
PROTEIN
URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 11 ARG A 188
SER A 182
PHE B  69
LEU B  46
PRO B  37
 None
 1.21A 1mxfC-3wdgA:
undetectable		 1mxfC-3wdgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 167
ILE A 168
LEU A 115
VAL A  54
LEU A  56
 None
 1.05A 2bxfB-3wdgA:
undetectable		 2bxfB-3wdgA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 6 ARG A  99
GLU A  90
PRO A 195
ALA A 199
 None
 1.21A 2ejfB-3wdgA:
undetectable		 2ejfB-3wdgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 7 ARG A  99
GLU A  90
PRO A 195
ALA A 199
 None
 1.18A 2ejgA-3wdgA:
undetectable		 2ejgA-3wdgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 12 PRO A  60
THR A 117
VAL A 118
LEU A  23
ILE A 132
 None
 1.40A 2fj1A-3wdgA:
undetectable		 2fj1A-3wdgA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		3 / 3 LYS A 149
LYS A  52
VAL A 152
 None
 1.08A 3brfA-3wdgA:
undetectable		 3brfA-3wdgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3wdg UNCHARACTERIZED
PROTEIN
URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 11 TYR A  61
VAL A  74
PRO A 102
ILE B  28
PRO A 181
 None
 1.50A 3ganA-3wdgA:
undetectable		 3ganA-3wdgA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 3wdg UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 9 ILE B  78
ASN B  48
ALA B  32
LEU B  94
ASN B  96
 None
 1.17A 3o01A-3wdgB:
undetectable
3o01B-3wdgB:
undetectable		 3o01A-3wdgB:
15.91
3o01B-3wdgB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3wdg UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		5 / 10 ILE B  78
ASN B  48
ALA B  32
LEU B  94
ASN B  96
 None
 1.15A 3o02A-3wdgB:
undetectable
3o02B-3wdgB:
undetectable		 3o02A-3wdgB:
15.91
3o02B-3wdgB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3wdg UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		4 / 5 TYR B  54
THR B  55
PHE B  69
LEU B   3
 None
 0.98A 3qelC-3wdgB:
undetectable		 3qelC-3wdgB:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3wdg UNCHARACTERIZED
PROTEIN
(Staphylococcus
aureus) 		3 / 3 PHE B  69
GLN B  52
PHE B  91
 None
 0.80A 3rv5A-3wdgB:
undetectable		 3rv5A-3wdgB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 5 ILE A  10
THR A  11
THR A  12
PHE A  16
 None
 1.11A 3snfA-3wdgA:
undetectable		 3snfA-3wdgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		3 / 3 LEU A  23
HIS A  20
MET A  19
 None
 0.90A 3thrD-3wdgA:
undetectable		 3thrD-3wdgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE505_1
(HEMOLYTIC LECTIN
CEL-III)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 5 GLU A 125
GLY A 124
TYR A  33
GLN A  66
 None
 0.84A 3w9tE-3wdgA:
undetectable		 3w9tE-3wdgA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3wdg UNCHARACTERIZED
PROTEIN
URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 11 GLY A  57
ASN A 116
ALA A  67
PRO A 160
ILE B  28
 None
 1.48A 4j4vA-3wdgA:
undetectable		 4j4vA-3wdgA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 8 TYR A 196
VAL A 153
LEU A 104
LEU A 114
 None
 0.95A 4l1xA-3wdgA:
undetectable		 4l1xA-3wdgA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 10 LEU A 115
LEU A  56
LEU A 156
ILE A 141
VAL A 152
 None
 1.42A 4mk4A-3wdgA:
undetectable		 4mk4A-3wdgA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 8 GLN A  58
PHE A  72
SER A  83
HIS A 180
 None
 0.74A 4wryA-3wdgA:
30.4		 4wryA-3wdgA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		6 / 8 GLY A  57
GLN A  58
TYR A  61
PHE A  72
SER A  83
ASN A 116
 None
 1.01A 4wryA-3wdgA:
30.4		 4wryA-3wdgA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 8 GLN A  58
TYR A  61
PHE A  72
SER A  83
HIS A 180
 None
 0.94A 4wrzA-3wdgA:
29.9		 4wrzA-3wdgA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		6 / 8 GLY A  57
GLN A  58
TYR A  61
PHE A  72
SER A  83
ASN A 116
 None
 1.01A 4wrzA-3wdgA:
29.9		 4wrzA-3wdgA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 7 GLN A  58
TYR A  61
PHE A  72
HIS A 180
 None
 1.17A 4ws0A-3wdgA:
29.9		 4ws0A-3wdgA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 7 GLY A  57
GLN A  58
TYR A  61
PHE A  72
ASN A 116
 None
 0.72A 4ws0A-3wdgA:
29.9		 4ws0A-3wdgA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		6 / 8 GLY A  57
GLN A  58
TYR A  61
PHE A  72
SER A  83
ASN A 116
 None
 0.87A 4ws1A-3wdgA:
30.0		 4ws1A-3wdgA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 8 TYR A  61
PHE A  72
SER A  83
HIS A 180
 None
 0.79A 4ws1A-3wdgA:
30.0		 4ws1A-3wdgA:
37.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		4 / 6 ASP A 106
ILE A 211
TYR A 196
TYR A  88
 None
 1.33A 5igyA-3wdgA:
undetectable		 5igyA-3wdgA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 3wdg URACIL-DNA
GLYCOSYLASE
(Staphylococcus
aureus) 		5 / 12 VAL A  54
PHE A 154
ILE A 141
VAL A 152
HIS A 173
 None
 0.94A 5uvmB-3wdgA:
undetectable		 5uvmB-3wdgA:
19.83