SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		4 / 7 THR A  20
TRP A  11
GLY A  94
ASP A  93
 None
 0.89A 1bu5A-3wdnA:
undetectable		 1bu5A-3wdnA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		4 / 4 VAL A  72
THR A  73
VAL A  18
GLY A  19
 None
 1.17A 2p2fB-3wdnA:
undetectable		 2p2fB-3wdnA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		5 / 12 ALA A  61
LEU A  31
GLU A  56
ILE A  23
LEU A  96
 None
 1.11A 3fl9B-3wdnA:
undetectable		 3fl9B-3wdnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		5 / 12 ALA A  61
LEU A  31
GLU A  56
ILE A  23
LEU A  96
 None
 1.14A 3fl9G-3wdnA:
undetectable		 3fl9G-3wdnA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		4 / 8 GLY A  22
PRO A  67
PHE A  52
ILE A  97
 None
 0.86A 4j4vC-3wdnA:
undetectable		 4j4vC-3wdnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		4 / 7 PHE A  52
SER A  38
ALA A  54
PRO A  40
 None
 0.93A 5dzkD-3wdnA:
undetectable
5dzkR-3wdnA:
undetectable		 5dzkD-3wdnA:
21.40
5dzkR-3wdnA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		4 / 8 PHE A  52
SER A  38
ALA A  54
PRO A  40
 None
 0.94A 5dzkd-3wdnA:
undetectable
5dzkr-3wdnA:
undetectable		 5dzkd-3wdnA:
21.40
5dzkr-3wdnA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		4 / 8 PHE A  52
SER A  38
ALA A  54
PRO A  40
 None
 0.93A 5dzkF-3wdnA:
undetectable
5dzkT-3wdnA:
undetectable		 5dzkF-3wdnA:
21.40
5dzkT-3wdnA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 3wdn GLYCINE CLEAVAGE
SYSTEM H PROTEIN,
MITOCHONDRIAL
(Bos
taurus) 		5 / 12 PRO A  67
ILE A  97
GLY A  53
PHE A  52
TYR A  36
 None
 1.09A 6qxsB-3wdnA:
undetectable		 6qxsB-3wdnA:
17.30