SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3wdo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 6 PRO A 391
MET A 277
ALA A 271
GLU A 272
 None
 1.50A 1qhyA-3wdoA:
undetectable		 1qhyA-3wdoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 7 LEU A  17
MET A 340
VAL A 342
SER A 344
 None
 1.04A 1wrlA-3wdoA:
0.0
1wrlB-3wdoA:
undetectable		 1wrlA-3wdoA:
13.36
1wrlB-3wdoA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 11 ALA A 378
GLY A 220
ILE A 221
ALA A 315
ILE A 288
 None
 1.02A 2idwA-3wdoA:
undetectable		 2idwA-3wdoA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 12 PRO A 324
ALA A 383
LEU A 382
ALA A 379
MET A 222
 None
 1.15A 2jjpA-3wdoA:
undetectable		 2jjpA-3wdoA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 4 LYS A 278
ALA A 385
PHE A 219
GLY A 220
 None
 1.47A 2rddA-3wdoA:
1.7		 2rddA-3wdoA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 7 THR A 182
ILE A 179
GLY A 178
ILE A 116
 None
 0.86A 2y7wC-3wdoA:
undetectable		 2y7wC-3wdoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 12 ALA A 119
MET A 137
ILE A 140
GLY A  18
LEU A  17
 None
 1.15A 2yjaB-3wdoA:
undetectable		 2yjaB-3wdoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 12 MET A 121
MET A 137
PHE A 144
ILE A 140
LEU A 215
 None
 1.40A 3aocC-3wdoA:
0.5		 3aocC-3wdoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 8 GLY A  69
ILE A 327
PHE A 144
PHE A  21
 None
 0.92A 3ko0B-3wdoA:
undetectable
3ko0J-3wdoA:
undetectable		 3ko0B-3wdoA:
12.92
3ko0J-3wdoA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 8 GLY A  69
ILE A 327
PHE A 144
PHE A  21
 None
 1.04A 3ko0K-3wdoA:
undetectable
3ko0S-3wdoA:
undetectable		 3ko0K-3wdoA:
12.92
3ko0S-3wdoA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 9 ILE A  56
GLY A  55
THR A  60
GLN A 111
GLY A 112
 None
 1.05A 4acaB-3wdoA:
undetectable
4acaC-3wdoA:
undetectable		 4acaB-3wdoA:
24.15
4acaC-3wdoA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFL_B_GCSB502_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 6 GLN A  61
MET A  28
ALA A 117
PHE A 144
 None
 1.36A 4mflA-3wdoA:
0.0		 4mflA-3wdoA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFQ_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 6 GLN A  61
MET A  28
ALA A 117
PHE A 144
 None
 1.37A 4mfqA-3wdoA:
0.0		 4mfqA-3wdoA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_1
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 4 SER A 190
GLU A 130
GLU A 272
ASP A 126
 None
 1.48A 4pclB-3wdoA:
0.0		 4pclB-3wdoA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 7 ALA A  53
LEU A  35
LEU A  32
ILE A  56
 None
 0.85A 4ubsA-3wdoA:
undetectable		 4ubsA-3wdoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 9 SER A  92
PHE A  68
GLY A  83
ILE A 116
ALA A 119
 None
 1.39A 5entC-3wdoA:
5.2		 5entC-3wdoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 12 ALA A 119
MET A 137
ILE A 140
GLY A  18
LEU A  17
 None
 1.11A 5gs4A-3wdoA:
undetectable		 5gs4A-3wdoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 10 ALA A 122
SER A 125
GLY A 341
ALA A 339
SER A 331
 None
 1.09A 5l66K-3wdoA:
undetectable
5l66L-3wdoA:
undetectable		 5l66K-3wdoA:
17.94
5l66L-3wdoA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 10 ALA A 122
SER A 125
GLY A 341
ALA A 339
SER A 331
 None
 1.08A 5l66Y-3wdoA:
undetectable
5l66Z-3wdoA:
undetectable		 5l66Y-3wdoA:
17.94
5l66Z-3wdoA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		5 / 12 PHE A  21
ILE A 116
GLY A 178
THR A 147
ALA A 172
 None
 1.13A 5x66F-3wdoA:
undetectable		 5x66F-3wdoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 8 ILE A 451
THR A 442
VAL A 441
GLU A 419
 None
 0.70A 6fbvC-3wdoA:
undetectable		 6fbvC-3wdoA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3wdo MFS TRANSPORTER
(Escherichia
coli) 		4 / 8 ALA A 291
GLY A 286
LEU A 287
ALA A 315
 None
 0.70A 6mdqA-3wdoA:
1.8		 6mdqA-3wdoA:
9.27