SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3we9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		4 / 8 PHE A 101
CYH A  51
VAL A  47
GLY A 133
 None
None
None
PGE  A 900 ( 4.3A)
 0.90A 1ekjE-3we9A:
undetectable
1ekjF-3we9A:
undetectable		 1ekjE-3we9A:
23.00
1ekjF-3we9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		5 / 11 LEU A 137
LEU A 140
SER A 230
LEU A 225
ALA A 151
 None
 1.21A 1tz8A-3we9A:
undetectable
1tz8B-3we9A:
undetectable		 1tz8A-3we9A:
19.34
1tz8B-3we9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		5 / 11 LEU A 225
ALA A 151
LEU A 137
LEU A 140
SER A 230
 None
 1.20A 1tz8A-3we9A:
undetectable
1tz8B-3we9A:
undetectable		 1tz8A-3we9A:
19.34
1tz8B-3we9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		4 / 8 ALA A 200
VAL A 197
THR A 196
PHE A 201
 None
 1.25A 2kotB-3we9A:
undetectable		 2kotB-3we9A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		5 / 12 GLY A 156
GLY A 129
VAL A 162
ALA A 152
LEU A 238
 PGE  A 900 ( 3.8A)
PGE  A 900 ( 3.8A)
None
None
None
 1.11A 3dh0B-3we9A:
undetectable		 3dh0B-3we9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_A_CLYA900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		5 / 10 TYR A 115
GLU A 120
TYR A 124
PHE A 164
ILE A 208
 None
 1.17A 3jz0A-3we9A:
0.0		 3jz0A-3we9A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		5 / 8 TYR A 115
GLU A 120
TYR A 124
PHE A 164
ILE A 208
 None
 1.22A 3jz0B-3we9A:
2.0		 3jz0B-3we9A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		4 / 6 PHE A  87
SER A  49
ALA A  46
LEU A  83
 None
 1.28A 5dzkg-3we9A:
undetectable
5dzku-3we9A:
undetectable		 5dzkg-3we9A:
22.77
5dzku-3we9A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3we9 PUTATIVE
PHYTOENE/SQUALENE
SYNTHASE YISP
(Bacillus
subtilis) 		5 / 12 ILE A 248
HIS A 253
THR A 202
LEU A 216
ALA A 212
 None
 1.04A 6djzA-3we9A:
undetectable		 6djzA-3we9A:
23.47